Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

3X43

Crystal structure of O-ureido-L-serine synthase

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004124	molecular_function	cysteine synthase activity
A	0006535	biological_process	L-cysteine biosynthetic process from L-serine
A	0008652	biological_process	amino acid biosynthetic process
A	0016740	molecular_function	transferase activity
A	0016765	molecular_function	transferase activity, transferring alkyl or aryl (other than methyl) groups
A	0017000	biological_process	antibiotic biosynthetic process
A	0019344	biological_process	L-cysteine biosynthetic process
B	0004124	molecular_function	cysteine synthase activity
B	0006535	biological_process	L-cysteine biosynthetic process from L-serine
B	0008652	biological_process	amino acid biosynthetic process
B	0016740	molecular_function	transferase activity
B	0016765	molecular_function	transferase activity, transferring alkyl or aryl (other than methyl) groups
B	0017000	biological_process	antibiotic biosynthetic process
B	0019344	biological_process	L-cysteine biosynthetic process
C	0004124	molecular_function	cysteine synthase activity
C	0006535	biological_process	L-cysteine biosynthetic process from L-serine
C	0008652	biological_process	amino acid biosynthetic process
C	0016740	molecular_function	transferase activity
C	0016765	molecular_function	transferase activity, transferring alkyl or aryl (other than methyl) groups
C	0017000	biological_process	antibiotic biosynthetic process
C	0019344	biological_process	L-cysteine biosynthetic process
D	0004124	molecular_function	cysteine synthase activity
D	0006535	biological_process	L-cysteine biosynthetic process from L-serine
D	0008652	biological_process	amino acid biosynthetic process
D	0016740	molecular_function	transferase activity
D	0016765	molecular_function	transferase activity, transferring alkyl or aryl (other than methyl) groups
D	0017000	biological_process	antibiotic biosynthetic process
D	0019344	biological_process	L-cysteine biosynthetic process
E	0004124	molecular_function	cysteine synthase activity
E	0006535	biological_process	L-cysteine biosynthetic process from L-serine
E	0008652	biological_process	amino acid biosynthetic process
E	0016740	molecular_function	transferase activity
E	0016765	molecular_function	transferase activity, transferring alkyl or aryl (other than methyl) groups
E	0017000	biological_process	antibiotic biosynthetic process
E	0019344	biological_process	L-cysteine biosynthetic process
F	0004124	molecular_function	cysteine synthase activity
F	0006535	biological_process	L-cysteine biosynthetic process from L-serine
F	0008652	biological_process	amino acid biosynthetic process
F	0016740	molecular_function	transferase activity
F	0016765	molecular_function	transferase activity, transferring alkyl or aryl (other than methyl) groups
F	0017000	biological_process	antibiotic biosynthetic process
F	0019344	biological_process	L-cysteine biosynthetic process
G	0004124	molecular_function	cysteine synthase activity
G	0006535	biological_process	L-cysteine biosynthetic process from L-serine
G	0008652	biological_process	amino acid biosynthetic process
G	0016740	molecular_function	transferase activity
G	0016765	molecular_function	transferase activity, transferring alkyl or aryl (other than methyl) groups
G	0017000	biological_process	antibiotic biosynthetic process
G	0019344	biological_process	L-cysteine biosynthetic process
H	0004124	molecular_function	cysteine synthase activity
H	0006535	biological_process	L-cysteine biosynthetic process from L-serine
H	0008652	biological_process	amino acid biosynthetic process
H	0016740	molecular_function	transferase activity
H	0016765	molecular_function	transferase activity, transferring alkyl or aryl (other than methyl) groups
H	0017000	biological_process	antibiotic biosynthetic process
H	0019344	biological_process	L-cysteine biosynthetic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	17
Details	BINDING SITE FOR RESIDUE PLP A 401

Chain	Residue
A	LYS43
A	GLY221
A	LEU222
A	SER265
A	PRO291
A	ASP292
A	TYR297
A	HOH510
A	HOH517
A	ASN73
A	PHE176
A	GLY177
A	THR178
A	THR179
A	GLY180
A	THR181
A	GLN220

site_id	AC2
Number of Residues	14
Details	BINDING SITE FOR RESIDUE PLP B 401

Chain	Residue
B	LYS43
B	ASN73
B	PHE176
B	GLY177
B	THR178
B	THR179
B	THR181
B	GLY221
B	SER265
B	PRO291
B	ASP292
B	TYR297
B	HOH512
B	HOH520

site_id	AC3
Number of Residues	15
Details	BINDING SITE FOR RESIDUE PLP C 401

Chain	Residue
C	LYS43
C	ASN73
C	PHE176
C	GLY177
C	THR178
C	THR179
C	GLY180
C	THR181
C	GLN220
C	SER265
C	PRO291
C	ASP292
C	TYR297
C	HOH507
C	HOH509

site_id	AC4
Number of Residues	18
Details	BINDING SITE FOR RESIDUE PLP D 401

Chain	Residue
D	LYS43
D	ASN73
D	PHE176
D	GLY177
D	THR178
D	THR179
D	GLY180
D	THR181
D	GLN220
D	GLY221
D	LEU222
D	SER265
D	PRO291
D	ASP292
D	TYR297
D	HOH503
D	HOH504
D	HOH508

site_id	AC5
Number of Residues	15
Details	BINDING SITE FOR RESIDUE PLP E 401

Chain	Residue
E	LYS43
E	ASN73
E	PHE176
E	GLY177
E	THR178
E	THR179
E	GLY180
E	THR181
E	GLN220
E	LEU222
E	SER265
E	PRO291
E	ASP292
E	TYR297
E	HOH520

site_id	AC6
Number of Residues	18
Details	BINDING SITE FOR RESIDUE PLP F 401

Chain	Residue
F	LYS43
F	ASN73
F	PHE176
F	GLY177
F	THR178
F	THR179
F	GLY180
F	THR181
F	GLN220
F	GLY221
F	LEU222
F	SER265
F	PRO291
F	ASP292
F	TYR297
F	HOH508
F	HOH511
F	HOH526

site_id	AC7
Number of Residues	16
Details	BINDING SITE FOR RESIDUE PLP G 401

Chain	Residue
G	PHE176
G	GLY177
G	THR178
G	THR179
G	GLY180
G	THR181
G	GLY221
G	LEU222
G	SER265
G	PRO291
G	ASP292
G	TYR297
G	HOH506
G	HOH507
G	LYS43
G	ASN73

site_id	AC8
Number of Residues	17
Details	BINDING SITE FOR RESIDUE PLP H 401

Chain	Residue
H	LYS43
H	ASN73
H	PHE176
H	GLY177
H	THR178
H	THR179
H	GLY180
H	THR181
H	GLN220
H	GLY221
H	SER265
H	PRO291
H	ASP292
H	TYR297
H	HOH505
H	HOH521
H	HOH527

Functional Information from PROSITE/UniProt

site_id	PS00901
Number of Residues	19
Details	CYS_SYNTHASE Cysteine synthase/cystathionine beta-synthase P-phosphate attachment site. KvEsfn.PGgSVKdRlAlsV

Chain	Residue	Details
A	LYS32-VAL50

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	48
Details	Binding site: {"evidences":[{"source":"PDB","id":"3X43","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	8
Details	Modified residue: {"description":"N6-(pyridoxal phosphate)lysine","evidences":[{"source":"PubMed","id":"26207937","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3X43","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)