3WXQ
Serial femtosecond X-ray structure of human fatty acid-binding protein type-3 (FABP3) in complex with stearic acid (C18:0) determined using X-ray free-electron laser at SACLA
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005324 | molecular_function | long-chain fatty acid transmembrane transporter activity |
| A | 0005504 | molecular_function | fatty acid binding |
| A | 0005515 | molecular_function | protein binding |
| A | 0005615 | cellular_component | extracellular space |
| A | 0005634 | cellular_component | nucleus |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0006631 | biological_process | fatty acid metabolic process |
| A | 0008092 | molecular_function | cytoskeletal protein binding |
| A | 0008285 | biological_process | negative regulation of cell population proliferation |
| A | 0008289 | molecular_function | lipid binding |
| A | 0009410 | biological_process | response to xenobiotic stimulus |
| A | 0015909 | biological_process | long-chain fatty acid transport |
| A | 0016528 | cellular_component | sarcoplasm |
| A | 0032365 | biological_process | intracellular lipid transport |
| A | 0032868 | biological_process | response to insulin |
| A | 0036041 | molecular_function | long-chain fatty acid binding |
| A | 0042632 | biological_process | cholesterol homeostasis |
| A | 0046320 | biological_process | regulation of fatty acid oxidation |
| A | 0050543 | molecular_function | icosatetraenoic acid binding |
| A | 0050873 | biological_process | brown fat cell differentiation |
| A | 0055091 | biological_process | phospholipid homeostasis |
| A | 0070062 | cellular_component | extracellular exosome |
| A | 0070538 | molecular_function | oleic acid binding |
| A | 0070542 | biological_process | response to fatty acid |
| A | 0071073 | biological_process | positive regulation of phospholipid biosynthetic process |
| A | 0140214 | biological_process | positive regulation of long-chain fatty acid import into cell |
| A | 2001245 | biological_process | regulation of phosphatidylcholine biosynthetic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE STE A 200 |
| Chain | Residue |
| A | THR54 |
| A | LYS59 |
| A | ARG79 |
| A | LEU116 |
| A | ARG127 |
| A | TYR129 |
| A | HOH337 |
| A | HOH367 |
Functional Information from PROSITE/UniProt
| site_id | PS00214 |
| Number of Residues | 18 |
| Details | FABP Cytosolic fatty-acid binding proteins signature. GTWkLvdSkNFDdYMKSL |
| Chain | Residue | Details |
| A | GLY7-LEU24 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"7922029","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1HMT","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"N-acetylvaline","evidences":[{"source":"PubMed","id":"22223895","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"UniProtKB","id":"P07483","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphotyrosine; by Tyr-kinases","evidences":[{"source":"UniProtKB","id":"P07483","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P07483","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
