Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004222 | molecular_function | metalloendopeptidase activity |
| A | 0006508 | biological_process | proteolysis |
| A | 0008237 | molecular_function | metallopeptidase activity |
| A | 0008270 | molecular_function | zinc ion binding |
| A | 0031012 | cellular_component | extracellular matrix |
| B | 0004222 | molecular_function | metalloendopeptidase activity |
| B | 0006508 | biological_process | proteolysis |
| B | 0008237 | molecular_function | metallopeptidase activity |
| B | 0008270 | molecular_function | zinc ion binding |
| B | 0031012 | cellular_component | extracellular matrix |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN A 301 |
| Chain | Residue |
| A | HIS222 |
| A | HIS226 |
| A | HIS232 |
| A | HOH602 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN A 302 |
| Chain | Residue |
| A | HIS172 |
| A | ASP174 |
| A | HIS187 |
| A | HIS200 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA A 303 |
| Chain | Residue |
| A | GLY180 |
| A | SER182 |
| A | LEU184 |
| A | ASP202 |
| A | GLU205 |
| A | ASP179 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA A 304 |
| Chain | Residue |
| A | ASP162 |
| A | ASN194 |
| A | GLY196 |
| A | ASP198 |
| A | HOH693 |
| A | HOH695 |
| site_id | AC5 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE NA A 305 |
| Chain | Residue |
| A | ASP128 |
| A | ASP203 |
| A | GLU205 |
| site_id | AC6 |
| Number of Residues | 17 |
| Details | BINDING SITE FOR RESIDUE WGG A 306 |
| Chain | Residue |
| A | LEU218 |
| A | VAL219 |
| A | HIS222 |
| A | GLU223 |
| A | ALA238 |
| A | LEU239 |
| A | PHE241 |
| A | PRO242 |
| A | ILE243 |
| A | TYR244 |
| A | THR245 |
| A | TYR246 |
| A | THR247 |
| A | PHE252 |
| A | MET253 |
| A | PRO255 |
| A | HOH615 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN B 301 |
| Chain | Residue |
| B | HIS222 |
| B | HIS226 |
| B | HIS232 |
| B | HOH473 |
| site_id | AC8 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN B 302 |
| Chain | Residue |
| B | HIS172 |
| B | ASP174 |
| B | HIS187 |
| B | HIS200 |
| site_id | AC9 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA B 303 |
| Chain | Residue |
| B | ASP179 |
| B | GLY180 |
| B | SER182 |
| B | LEU184 |
| B | ASP202 |
| B | GLU205 |
| site_id | BC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA B 304 |
| Chain | Residue |
| B | ASP162 |
| B | ASN194 |
| B | GLY196 |
| B | ASP198 |
| B | HOH470 |
| B | HOH489 |
| site_id | BC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE NA B 305 |
| Chain | Residue |
| B | ASP128 |
| B | ASP203 |
| B | GLU205 |
| B | HOH476 |
| B | HOH486 |
| site_id | BC3 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE WGG B 306 |
| Chain | Residue |
| B | LEU218 |
| B | HIS222 |
| B | GLU223 |
| B | ALA238 |
| B | LEU239 |
| B | PHE241 |
| B | ILE243 |
| B | TYR244 |
| B | THR245 |
| B | THR247 |
| B | PHE252 |
| B | MET253 |
| B | HOH411 |
Functional Information from PROSITE/UniProt
| site_id | PS00142 |
| Number of Residues | 10 |
| Details | ZINC_PROTEASE Neutral zinc metallopeptidases, zinc-binding region signature. VAAHEFGHSL |
| Chain | Residue | Details |
| A | VAL219-LEU228 | |
Functional Information from SwissProt/UniProt
| Chain | Residue | Details |
| A | GLU223 | |
| B | GLU223 | |
| site_id | SWS_FT_FI2 |
| Number of Residues | 24 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:10926524, ECO:0000269|PubMed:10986126, ECO:0000269|PubMed:15734645, ECO:0000269|PubMed:15780611, ECO:0000269|PubMed:17196980, ECO:0000269|PubMed:17623656, ECO:0000269|PubMed:19422229, ECO:0000269|PubMed:20005097, ECO:0000269|PubMed:20726512, ECO:0000269|PubMed:22689580, ECO:0000269|PubMed:23810497, ECO:0000269|PubMed:23913860, ECO:0000269|PubMed:8969305 |
| Chain | Residue | Details |
| A | ASP128 | |
| A | ASP202 | |
| A | ASP203 | |
| A | GLU205 | |
| B | ASP128 | |
| B | ASP162 | |
| B | ASP179 | |
| B | GLY180 | |
| B | SER182 | |
| B | LEU184 | |
| B | ASN194 | |
| A | ASP162 | |
| B | GLY196 | |
| B | ASP198 | |
| B | ASP202 | |
| B | ASP203 | |
| B | GLU205 | |
| A | ASP179 | |
| A | GLY180 | |
| A | SER182 | |
| A | LEU184 | |
| A | ASN194 | |
| A | GLY196 | |
| A | ASP198 | |
| site_id | SWS_FT_FI3 |
| Number of Residues | 16 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:10926524, ECO:0000269|PubMed:10986126, ECO:0000269|PubMed:15734645, ECO:0000269|PubMed:15780611, ECO:0000269|PubMed:17196980, ECO:0000269|PubMed:17623656, ECO:0000269|PubMed:19422229, ECO:0000269|PubMed:20005097, ECO:0000269|PubMed:20726512, ECO:0000269|PubMed:22689580, ECO:0000269|PubMed:23810497, ECO:0000269|PubMed:23913860 |
| Chain | Residue | Details |
| A | HIS172 | |
| B | ASP174 | |
| B | HIS187 | |
| B | HIS200 | |
| B | HIS222 | |
| B | HIS226 | |
| B | HIS232 | |
| B | MET240 | |
| A | ASP174 | |
| A | HIS187 | |
| A | HIS200 | |
| A | HIS222 | |
| A | HIS226 | |
| A | HIS232 | |
| A | MET240 | |
| B | HIS172 | |
| Chain | Residue | Details |
| A | ASN117 | |
| B | ASN117 | |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
| Chain | Residue | Details |
| A | ASN152 | |
| B | ASN152 | |
