Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

3WS6

Crystal Structure of H-2D in complex with a mimotopic peptide

Functional Information from GO Data

Chain	GOid	namespace	contents
C	0001913	biological_process	T cell mediated cytotoxicity
C	0001916	biological_process	positive regulation of T cell mediated cytotoxicity
C	0002237	biological_process	response to molecule of bacterial origin
C	0002474	biological_process	antigen processing and presentation of peptide antigen via MHC class I
C	0002481	biological_process	antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent
C	0002502	biological_process	peptide antigen assembly with MHC class I protein complex
C	0002726	biological_process	positive regulation of T cell cytokine production
C	0005198	molecular_function	structural molecule activity
C	0005515	molecular_function	protein binding
C	0005576	cellular_component	extracellular region
C	0005615	cellular_component	extracellular space
C	0005794	cellular_component	Golgi apparatus
C	0005829	cellular_component	cytosol
C	0005886	cellular_component	plasma membrane
C	0006826	biological_process	iron ion transport
C	0006879	biological_process	intracellular iron ion homeostasis
C	0006955	biological_process	immune response
C	0006968	biological_process	cellular defense response
C	0007608	biological_process	sensory perception of smell
C	0007611	biological_process	learning or memory
C	0009897	cellular_component	external side of plasma membrane
C	0010977	biological_process	negative regulation of neuron projection development
C	0019885	biological_process	antigen processing and presentation of endogenous peptide antigen via MHC class I
C	0030670	cellular_component	phagocytic vesicle membrane
C	0033077	biological_process	T cell differentiation in thymus
C	0034756	biological_process	regulation of iron ion transport
C	0042026	biological_process	protein refolding
C	0042612	cellular_component	MHC class I protein complex
C	0042802	molecular_function	identical protein binding
C	0042803	molecular_function	protein homodimerization activity
C	0042824	cellular_component	MHC class I peptide loading complex
C	0045646	biological_process	regulation of erythrocyte differentiation
C	0048260	biological_process	positive regulation of receptor-mediated endocytosis
C	0050680	biological_process	negative regulation of epithelial cell proliferation
C	0050768	biological_process	negative regulation of neurogenesis
C	0051289	biological_process	protein homotetramerization
C	0060586	biological_process	multicellular organismal-level iron ion homeostasis
C	0071281	biological_process	cellular response to iron ion
C	0071283	biological_process	cellular response to iron(III) ion
C	0071316	biological_process	cellular response to nicotine
C	1990000	biological_process	amyloid fibril formation
C	1990712	cellular_component	HFE-transferrin receptor complex
C	2000774	biological_process	positive regulation of cellular senescence
C	2000978	biological_process	negative regulation of forebrain neuron differentiation
D	0001913	biological_process	T cell mediated cytotoxicity
D	0001916	biological_process	positive regulation of T cell mediated cytotoxicity
D	0002237	biological_process	response to molecule of bacterial origin
D	0002474	biological_process	antigen processing and presentation of peptide antigen via MHC class I
D	0002481	biological_process	antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent
D	0002502	biological_process	peptide antigen assembly with MHC class I protein complex
D	0002726	biological_process	positive regulation of T cell cytokine production
D	0005198	molecular_function	structural molecule activity
D	0005515	molecular_function	protein binding
D	0005576	cellular_component	extracellular region
D	0005615	cellular_component	extracellular space
D	0005794	cellular_component	Golgi apparatus
D	0005829	cellular_component	cytosol
D	0005886	cellular_component	plasma membrane
D	0006826	biological_process	iron ion transport
D	0006879	biological_process	intracellular iron ion homeostasis
D	0006955	biological_process	immune response
D	0006968	biological_process	cellular defense response
D	0007608	biological_process	sensory perception of smell
D	0007611	biological_process	learning or memory
D	0009897	cellular_component	external side of plasma membrane
D	0010977	biological_process	negative regulation of neuron projection development
D	0019885	biological_process	antigen processing and presentation of endogenous peptide antigen via MHC class I
D	0030670	cellular_component	phagocytic vesicle membrane
D	0033077	biological_process	T cell differentiation in thymus
D	0034756	biological_process	regulation of iron ion transport
D	0042026	biological_process	protein refolding
D	0042612	cellular_component	MHC class I protein complex
D	0042802	molecular_function	identical protein binding
D	0042803	molecular_function	protein homodimerization activity
D	0042824	cellular_component	MHC class I peptide loading complex
D	0045646	biological_process	regulation of erythrocyte differentiation
D	0048260	biological_process	positive regulation of receptor-mediated endocytosis
D	0050680	biological_process	negative regulation of epithelial cell proliferation
D	0050768	biological_process	negative regulation of neurogenesis
D	0051289	biological_process	protein homotetramerization
D	0060586	biological_process	multicellular organismal-level iron ion homeostasis
D	0071281	biological_process	cellular response to iron ion
D	0071283	biological_process	cellular response to iron(III) ion
D	0071316	biological_process	cellular response to nicotine
D	1990000	biological_process	amyloid fibril formation
D	1990712	cellular_component	HFE-transferrin receptor complex
D	2000774	biological_process	positive regulation of cellular senescence
D	2000978	biological_process	negative regulation of forebrain neuron differentiation

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 401

Chain	Residue
A	HIS193
A	GLU292
A	IMD402
A	IMD403

site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE IMD A 402

Chain	Residue
A	HOH548
A	TRP131
A	HIS193
A	GLU292
A	ZN401
A	IMD403

site_id	AC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE IMD A 403

Chain	Residue
A	HIS193
A	GLU292
A	ZN401
A	IMD402
A	HOH559
A	HOH667

site_id	AC4
Number of Residues	8
Details	BINDING SITE FOR RESIDUE GOL A 404

Chain	Residue
A	ARG30
A	TYR51
A	ASN54
A	HOH502
A	HOH526
A	HOH625
A	HOH680
D	HOH347

site_id	AC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN D 201

Chain	Residue
C	SO4202
D	HIS33
D	SO4202
D	IMD203

site_id	AC6
Number of Residues	10
Details	BINDING SITE FOR RESIDUE SO4 D 202

Chain	Residue
C	HIS33
C	ZN201
C	SO4202
C	IMD204
D	ARG32
D	HIS33
D	ZN201
D	IMD203
D	HOH334
D	HOH378

site_id	AC7
Number of Residues	7
Details	BINDING SITE FOR RESIDUE IMD D 203

Chain	Residue
C	SO4202
C	IMD204
D	PRO40
D	ILE42
D	GLU89
D	ZN201
D	SO4202

site_id	AC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN B 401

Chain	Residue
B	HIS193
B	GLU292
B	IMD402
B	IMD403

site_id	AC9
Number of Residues	6
Details	BINDING SITE FOR RESIDUE IMD B 402

Chain	Residue
B	TRP131
B	HIS193
B	ARG284
B	GLU292
B	ZN401
B	IMD403

site_id	BC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE IMD B 403

Chain	Residue
B	GLU190
B	HIS193
B	GLU292
B	ZN401
B	IMD402
B	GOL404

site_id	BC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE GOL B 404

Chain	Residue
B	GLU190
B	TRP191
B	ARG194
B	IMD403
B	HOH627

site_id	BC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE GOL B 405

Chain	Residue
B	ARG30
B	PHE32
B	TYR51
B	ASN54
B	HOH509
B	HOH692

site_id	BC4
Number of Residues	2
Details	BINDING SITE FOR RESIDUE GOL B 406

Chain	Residue
B	HIS27
B	LEU204

site_id	BC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN C 201

Chain	Residue
C	HIS33
C	SO4202
C	IMD204
D	SO4202

site_id	BC6
Number of Residues	10
Details	BINDING SITE FOR RESIDUE SO4 C 202

Chain	Residue
C	ARG32
C	HIS33
C	ZN201
C	IMD204
C	HOH315
C	HOH355
D	HIS33
D	ZN201
D	SO4202
D	IMD203

site_id	BC7
Number of Residues	10
Details	BINDING SITE FOR RESIDUE SO4 C 203

Chain	Residue
C	THR93
C	GLU94
C	ASP96
C	TRP115
C	ARG117
C	HOH327
C	HOH328
C	HOH330
C	HOH369
C	HOH414

site_id	BC8
Number of Residues	9
Details	BINDING SITE FOR RESIDUE IMD C 204

Chain	Residue
C	PRO40
C	ASN41
C	ILE42
C	GLU89
C	ZN201
C	SO4202
D	SO4202
D	IMD203
C	HIS33

Functional Information from PROSITE/UniProt

site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YTCRVYH

Chain	Residue	Details
A	TYR281-HIS287
D	TYR98-HIS104

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269\|PubMed:3980466, ECO:0000269\|PubMed:7118212

Chain	Residue	Details
A	ASN110
B	ASN110

site_id	SWS_FT_FI2
Number of Residues	2
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000305

Chain	Residue	Details
A	ASN200
B	ASN200

site_id	SWS_FT_FI3
Number of Residues	2
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269\|PubMed:3980466

Chain	Residue	Details
A	ASN280
B	ASN280

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)