3WPT
Crystal structure of closed dimer of human importin-alpha1 (Rch1)
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE PEG A 501 |
| Chain | Residue |
| A | GLU456 |
| site_id | AC2 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE PEG A 502 |
| Chain | Residue |
| A | GLN367 |
| A | VAL410 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE PEG A 503 |
| Chain | Residue |
| A | LYS388 |
| A | ALA389 |
| A | PHE391 |
| A | GLN394 |
| site_id | AC4 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE PEG A 504 |
| Chain | Residue |
| B | PHE391 |
| A | ARG227 |
| A | PEG505 |
| site_id | AC5 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE PEG A 505 |
| Chain | Residue |
| A | GLY224 |
| A | PEG504 |
| A | HOH684 |
| B | PHE391 |
| B | THR430 |
| B | ALA431 |
| B | LYS432 |
| B | HOH695 |
| site_id | AC6 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE PEG A 506 |
| Chain | Residue |
| A | GLU306 |
| site_id | AC7 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE PEG A 508 |
| Chain | Residue |
| A | ARG238 |
| A | TRP273 |
| A | TYR277 |
| site_id | AC8 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE PEG A 509 |
| Chain | Residue |
| A | ASN241 |
| B | SER152 |
| B | PEG503 |
| site_id | AC9 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE PEG A 510 |
| Chain | Residue |
| A | PHE391 |
| A | LYS432 |
| B | ARG227 |
| site_id | BC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE PEG A 511 |
| Chain | Residue |
| A | LYS353 |
| A | GLU354 |
| A | TRP357 |
| A | GLU396 |
| site_id | BC2 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE PEG B 501 |
| Chain | Residue |
| B | ARG315 |
| B | GLU396 |
| site_id | BC3 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE PEG B 502 |
| Chain | Residue |
| A | SER152 |
| B | LYS240 |
| site_id | BC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE PEG B 503 |
| Chain | Residue |
| A | LYS240 |
| A | PEG509 |
| B | SER149 |
| B | GLY150 |
| B | SER152 |
| site_id | BC5 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE PEG B 504 |
| Chain | Residue |
| B | VAL414 |
| B | GLU456 |
| B | LYS459 |
| site_id | BC6 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE PEG B 505 |
| Chain | Residue |
| B | GLN371 |
| site_id | BC7 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE PEG B 506 |
| Chain | Residue |
| B | VAL330 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 78 |
| Details | Repeat: {"description":"ARM 2"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 82 |
| Details | Repeat: {"description":"ARM 3"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 88 |
| Details | Repeat: {"description":"ARM 4"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 72 |
| Details | Repeat: {"description":"ARM 5"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 78 |
| Details | Repeat: {"description":"ARM 6"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 78 |
| Details | Repeat: {"description":"ARM 7"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 84 |
| Details | Repeat: {"description":"ARM 8"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 92 |
| Details | Repeat: {"description":"ARM 9"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 78 |
| Details | Repeat: {"description":"ARM 10; atypical"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 192 |
| Details | Region: {"description":"NLS binding site (major)","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 176 |
| Details | Region: {"description":"NLS binding site (minor)","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI12 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
