Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

3WNW

Structure of Mouse H-chain modified ferritin

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004322	molecular_function	ferroxidase activity
A	0005506	molecular_function	iron ion binding
A	0005576	cellular_component	extracellular region
A	0005737	cellular_component	cytoplasm
A	0005739	cellular_component	mitochondrion
A	0005764	cellular_component	lysosome
A	0005776	cellular_component	autophagosome
A	0005829	cellular_component	cytosol
A	0006826	biological_process	iron ion transport
A	0006879	biological_process	intracellular iron ion homeostasis
A	0006955	biological_process	immune response
A	0008198	molecular_function	ferrous iron binding
A	0008199	molecular_function	ferric iron binding
A	0008285	biological_process	negative regulation of cell population proliferation
A	0016020	cellular_component	membrane
A	0016491	molecular_function	oxidoreductase activity
A	0031410	cellular_component	cytoplasmic vesicle
A	0042802	molecular_function	identical protein binding
A	0044754	cellular_component	autolysosome
A	0046872	molecular_function	metal ion binding
A	0071682	cellular_component	endocytic vesicle lumen
A	0110076	biological_process	negative regulation of ferroptosis
B	0004322	molecular_function	ferroxidase activity
B	0005506	molecular_function	iron ion binding
B	0005576	cellular_component	extracellular region
B	0005737	cellular_component	cytoplasm
B	0005739	cellular_component	mitochondrion
B	0005764	cellular_component	lysosome
B	0005776	cellular_component	autophagosome
B	0005829	cellular_component	cytosol
B	0006826	biological_process	iron ion transport
B	0006879	biological_process	intracellular iron ion homeostasis
B	0006955	biological_process	immune response
B	0008198	molecular_function	ferrous iron binding
B	0008199	molecular_function	ferric iron binding
B	0008285	biological_process	negative regulation of cell population proliferation
B	0016020	cellular_component	membrane
B	0016491	molecular_function	oxidoreductase activity
B	0031410	cellular_component	cytoplasmic vesicle
B	0042802	molecular_function	identical protein binding
B	0044754	cellular_component	autolysosome
B	0046872	molecular_function	metal ion binding
B	0071682	cellular_component	endocytic vesicle lumen
B	0110076	biological_process	negative regulation of ferroptosis
C	0004322	molecular_function	ferroxidase activity
C	0005506	molecular_function	iron ion binding
C	0005576	cellular_component	extracellular region
C	0005737	cellular_component	cytoplasm
C	0005739	cellular_component	mitochondrion
C	0005764	cellular_component	lysosome
C	0005776	cellular_component	autophagosome
C	0005829	cellular_component	cytosol
C	0006826	biological_process	iron ion transport
C	0006879	biological_process	intracellular iron ion homeostasis
C	0006955	biological_process	immune response
C	0008198	molecular_function	ferrous iron binding
C	0008199	molecular_function	ferric iron binding
C	0008285	biological_process	negative regulation of cell population proliferation
C	0016020	cellular_component	membrane
C	0016491	molecular_function	oxidoreductase activity
C	0031410	cellular_component	cytoplasmic vesicle
C	0042802	molecular_function	identical protein binding
C	0044754	cellular_component	autolysosome
C	0046872	molecular_function	metal ion binding
C	0071682	cellular_component	endocytic vesicle lumen
C	0110076	biological_process	negative regulation of ferroptosis
D	0004322	molecular_function	ferroxidase activity
D	0005506	molecular_function	iron ion binding
D	0005576	cellular_component	extracellular region
D	0005737	cellular_component	cytoplasm
D	0005739	cellular_component	mitochondrion
D	0005764	cellular_component	lysosome
D	0005776	cellular_component	autophagosome
D	0005829	cellular_component	cytosol
D	0006826	biological_process	iron ion transport
D	0006879	biological_process	intracellular iron ion homeostasis
D	0006955	biological_process	immune response
D	0008198	molecular_function	ferrous iron binding
D	0008199	molecular_function	ferric iron binding
D	0008285	biological_process	negative regulation of cell population proliferation
D	0016020	cellular_component	membrane
D	0016491	molecular_function	oxidoreductase activity
D	0031410	cellular_component	cytoplasmic vesicle
D	0042802	molecular_function	identical protein binding
D	0044754	cellular_component	autolysosome
D	0046872	molecular_function	metal ion binding
D	0071682	cellular_component	endocytic vesicle lumen
D	0110076	biological_process	negative regulation of ferroptosis
E	0004322	molecular_function	ferroxidase activity
E	0005506	molecular_function	iron ion binding
E	0005576	cellular_component	extracellular region
E	0005737	cellular_component	cytoplasm
E	0005739	cellular_component	mitochondrion
E	0005764	cellular_component	lysosome
E	0005776	cellular_component	autophagosome
E	0005829	cellular_component	cytosol
E	0006826	biological_process	iron ion transport
E	0006879	biological_process	intracellular iron ion homeostasis
E	0006955	biological_process	immune response
E	0008198	molecular_function	ferrous iron binding
E	0008199	molecular_function	ferric iron binding
E	0008285	biological_process	negative regulation of cell population proliferation
E	0016020	cellular_component	membrane
E	0016491	molecular_function	oxidoreductase activity
E	0031410	cellular_component	cytoplasmic vesicle
E	0042802	molecular_function	identical protein binding
E	0044754	cellular_component	autolysosome
E	0046872	molecular_function	metal ion binding
E	0071682	cellular_component	endocytic vesicle lumen
E	0110076	biological_process	negative regulation of ferroptosis
F	0004322	molecular_function	ferroxidase activity
F	0005506	molecular_function	iron ion binding
F	0005576	cellular_component	extracellular region
F	0005737	cellular_component	cytoplasm
F	0005739	cellular_component	mitochondrion
F	0005764	cellular_component	lysosome
F	0005776	cellular_component	autophagosome
F	0005829	cellular_component	cytosol
F	0006826	biological_process	iron ion transport
F	0006879	biological_process	intracellular iron ion homeostasis
F	0006955	biological_process	immune response
F	0008198	molecular_function	ferrous iron binding
F	0008199	molecular_function	ferric iron binding
F	0008285	biological_process	negative regulation of cell population proliferation
F	0016020	cellular_component	membrane
F	0016491	molecular_function	oxidoreductase activity
F	0031410	cellular_component	cytoplasmic vesicle
F	0042802	molecular_function	identical protein binding
F	0044754	cellular_component	autolysosome
F	0046872	molecular_function	metal ion binding
F	0071682	cellular_component	endocytic vesicle lumen
F	0110076	biological_process	negative regulation of ferroptosis
G	0004322	molecular_function	ferroxidase activity
G	0005506	molecular_function	iron ion binding
G	0005576	cellular_component	extracellular region
G	0005737	cellular_component	cytoplasm
G	0005739	cellular_component	mitochondrion
G	0005764	cellular_component	lysosome
G	0005776	cellular_component	autophagosome
G	0005829	cellular_component	cytosol
G	0006826	biological_process	iron ion transport
G	0006879	biological_process	intracellular iron ion homeostasis
G	0006955	biological_process	immune response
G	0008198	molecular_function	ferrous iron binding
G	0008199	molecular_function	ferric iron binding
G	0008285	biological_process	negative regulation of cell population proliferation
G	0016020	cellular_component	membrane
G	0016491	molecular_function	oxidoreductase activity
G	0031410	cellular_component	cytoplasmic vesicle
G	0042802	molecular_function	identical protein binding
G	0044754	cellular_component	autolysosome
G	0046872	molecular_function	metal ion binding
G	0071682	cellular_component	endocytic vesicle lumen
G	0110076	biological_process	negative regulation of ferroptosis
H	0004322	molecular_function	ferroxidase activity
H	0005506	molecular_function	iron ion binding
H	0005576	cellular_component	extracellular region
H	0005737	cellular_component	cytoplasm
H	0005739	cellular_component	mitochondrion
H	0005764	cellular_component	lysosome
H	0005776	cellular_component	autophagosome
H	0005829	cellular_component	cytosol
H	0006826	biological_process	iron ion transport
H	0006879	biological_process	intracellular iron ion homeostasis
H	0006955	biological_process	immune response
H	0008198	molecular_function	ferrous iron binding
H	0008199	molecular_function	ferric iron binding
H	0008285	biological_process	negative regulation of cell population proliferation
H	0016020	cellular_component	membrane
H	0016491	molecular_function	oxidoreductase activity
H	0031410	cellular_component	cytoplasmic vesicle
H	0042802	molecular_function	identical protein binding
H	0044754	cellular_component	autolysosome
H	0046872	molecular_function	metal ion binding
H	0071682	cellular_component	endocytic vesicle lumen
H	0110076	biological_process	negative regulation of ferroptosis
I	0004322	molecular_function	ferroxidase activity
I	0005506	molecular_function	iron ion binding
I	0005576	cellular_component	extracellular region
I	0005737	cellular_component	cytoplasm
I	0005739	cellular_component	mitochondrion
I	0005764	cellular_component	lysosome
I	0005776	cellular_component	autophagosome
I	0005829	cellular_component	cytosol
I	0006826	biological_process	iron ion transport
I	0006879	biological_process	intracellular iron ion homeostasis
I	0006955	biological_process	immune response
I	0008198	molecular_function	ferrous iron binding
I	0008199	molecular_function	ferric iron binding
I	0008285	biological_process	negative regulation of cell population proliferation
I	0016020	cellular_component	membrane
I	0016491	molecular_function	oxidoreductase activity
I	0031410	cellular_component	cytoplasmic vesicle
I	0042802	molecular_function	identical protein binding
I	0044754	cellular_component	autolysosome
I	0046872	molecular_function	metal ion binding
I	0071682	cellular_component	endocytic vesicle lumen
I	0110076	biological_process	negative regulation of ferroptosis
J	0004322	molecular_function	ferroxidase activity
J	0005506	molecular_function	iron ion binding
J	0005576	cellular_component	extracellular region
J	0005737	cellular_component	cytoplasm
J	0005739	cellular_component	mitochondrion
J	0005764	cellular_component	lysosome
J	0005776	cellular_component	autophagosome
J	0005829	cellular_component	cytosol
J	0006826	biological_process	iron ion transport
J	0006879	biological_process	intracellular iron ion homeostasis
J	0006955	biological_process	immune response
J	0008198	molecular_function	ferrous iron binding
J	0008199	molecular_function	ferric iron binding
J	0008285	biological_process	negative regulation of cell population proliferation
J	0016020	cellular_component	membrane
J	0016491	molecular_function	oxidoreductase activity
J	0031410	cellular_component	cytoplasmic vesicle
J	0042802	molecular_function	identical protein binding
J	0044754	cellular_component	autolysosome
J	0046872	molecular_function	metal ion binding
J	0071682	cellular_component	endocytic vesicle lumen
J	0110076	biological_process	negative regulation of ferroptosis
K	0004322	molecular_function	ferroxidase activity
K	0005506	molecular_function	iron ion binding
K	0005576	cellular_component	extracellular region
K	0005737	cellular_component	cytoplasm
K	0005739	cellular_component	mitochondrion
K	0005764	cellular_component	lysosome
K	0005776	cellular_component	autophagosome
K	0005829	cellular_component	cytosol
K	0006826	biological_process	iron ion transport
K	0006879	biological_process	intracellular iron ion homeostasis
K	0006955	biological_process	immune response
K	0008198	molecular_function	ferrous iron binding
K	0008199	molecular_function	ferric iron binding
K	0008285	biological_process	negative regulation of cell population proliferation
K	0016020	cellular_component	membrane
K	0016491	molecular_function	oxidoreductase activity
K	0031410	cellular_component	cytoplasmic vesicle
K	0042802	molecular_function	identical protein binding
K	0044754	cellular_component	autolysosome
K	0046872	molecular_function	metal ion binding
K	0071682	cellular_component	endocytic vesicle lumen
K	0110076	biological_process	negative regulation of ferroptosis
L	0004322	molecular_function	ferroxidase activity
L	0005506	molecular_function	iron ion binding
L	0005576	cellular_component	extracellular region
L	0005737	cellular_component	cytoplasm
L	0005739	cellular_component	mitochondrion
L	0005764	cellular_component	lysosome
L	0005776	cellular_component	autophagosome
L	0005829	cellular_component	cytosol
L	0006826	biological_process	iron ion transport
L	0006879	biological_process	intracellular iron ion homeostasis
L	0006955	biological_process	immune response
L	0008198	molecular_function	ferrous iron binding
L	0008199	molecular_function	ferric iron binding
L	0008285	biological_process	negative regulation of cell population proliferation
L	0016020	cellular_component	membrane
L	0016491	molecular_function	oxidoreductase activity
L	0031410	cellular_component	cytoplasmic vesicle
L	0042802	molecular_function	identical protein binding
L	0044754	cellular_component	autolysosome
L	0046872	molecular_function	metal ion binding
L	0071682	cellular_component	endocytic vesicle lumen
L	0110076	biological_process	negative regulation of ferroptosis

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG A 201

Chain	Residue
A	GLU27
A	GLU62
A	HIS65
A	GLN141
A	HOH382
A	HOH383

site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG A 202

Chain	Residue
B	HOH328
B	HOH398
C	HOH331
A	HOH362
A	HOH392
A	HOH393

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE FE A 203

Chain	Residue
A	HIS173
D	HIS173
G	HIS173
J	HIS173

site_id	AC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE GOL A 204

Chain	Residue
A	SER38
A	CYS39
A	ASP42
F	GLU67
F	MET70
F	LYS71

site_id	AC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE GOL A 205

Chain	Residue
A	GLU67
F	SER38
F	ASP42
F	HOH357

site_id	AC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG B 201

Chain	Residue
B	GLU27
B	GLU62
B	HIS65
B	HOH383
B	HOH414

site_id	AC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE FE B 202

Chain	Residue
B	HIS173
B	HIS173
F	HIS173
F	HIS173

site_id	AC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE K B 203

Chain	Residue
B	ASN11
B	LYS124
B	HOH315
B	HOH333

site_id	AC9
Number of Residues	9
Details	BINDING SITE FOR RESIDUE MG C 201

Chain	Residue
A	ASP131
A	GLU134
A	HOH405
A	HOH421
B	HOH329
B	HOH397
B	HOH409
C	ASP131
C	GLU134

site_id	BC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG C 202

Chain	Residue
C	GLU27
C	GLU62
C	HIS65
C	GLN141
C	HOH341
C	HOH348

site_id	BC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE FE C 203

Chain	Residue
C	HIS173
E	HIS173
I	HIS173
K	HIS173

site_id	BC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE GOL C 204

Chain	Residue
C	GLU67
C	HOH353
J	SER38
J	ASP42

site_id	BC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE GOL C 205

Chain	Residue
C	SER38
C	CYS39
C	ASP42
C	HOH373
J	GLU67
J	ASN74

site_id	BC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE K C 206

Chain	Residue
C	TYR40
C	ASP92
C	HOH343

site_id	BC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG D 201

Chain	Residue
D	GLU27
D	GLU62
D	HIS65
D	HOH380
D	HOH381

site_id	BC7
Number of Residues	7
Details	BINDING SITE FOR RESIDUE MG D 202

Chain	Residue
D	HOH365
D	HOH366
D	HOH390
D	HOH405
D	HOH430
E	HOH361
F	HOH391

site_id	BC8
Number of Residues	6
Details	BINDING SITE FOR RESIDUE GOL D 203

Chain	Residue
D	SER38
D	CYS39
D	ASP42
D	HOH335
I	GLU67
I	ASN74

site_id	BC9
Number of Residues	3
Details	BINDING SITE FOR RESIDUE GOL D 204

Chain	Residue
D	GLU67
D	HOH360
I	SER38

site_id	CC1
Number of Residues	9
Details	BINDING SITE FOR RESIDUE MG E 201

Chain	Residue
F	GLU134
F	HOH302
D	ASP131
D	GLU134
D	HOH391
D	HOH430
E	ASP131
E	GLU134
E	HOH412

site_id	CC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG E 202

Chain	Residue
E	GLU27
E	GLU62
E	HIS65
E	GLN141
E	HOH372
E	HOH373

site_id	CC3
Number of Residues	7
Details	BINDING SITE FOR RESIDUE GOL E 203

Chain	Residue
B	SER38
B	CYS39
B	ASP42
E	GLU67
E	MET70
E	LYS71
E	HOH375

site_id	CC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE GOL E 204

Chain	Residue
B	GLU67
E	SER38
E	ASP42
E	HOH374

site_id	CC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG F 201

Chain	Residue
F	GLU27
F	GLU62
F	HIS65
F	HOH392
F	HOH393

site_id	CC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG G 201

Chain	Residue
G	GLU27
G	GLU62
G	HIS65
G	HOH415
G	HOH442

site_id	CC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG G 202

Chain	Residue
G	HOH327
G	HOH409
H	HOH379
H	HOH388
I	HOH372
I	HOH377

site_id	CC8
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG H 201

Chain	Residue
H	GLU27
H	GLU62
H	HIS65
H	GLN141
H	HOH310
H	HOH374

site_id	CC9
Number of Residues	4
Details	BINDING SITE FOR RESIDUE FE H 202

Chain	Residue
H	HIS173
H	HIS173
L	HIS173
L	HIS173

site_id	DC1
Number of Residues	8
Details	BINDING SITE FOR RESIDUE MG I 201

Chain	Residue
G	GLU134
G	HOH397
H	ASP131
H	HOH327
H	HOH413
I	ASP131
I	GLU134
I	HOH385

site_id	DC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG I 202

Chain	Residue
I	GLU27
I	GLU62
I	HIS65
I	HOH311
I	HOH398

site_id	DC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG J 201

Chain	Residue
J	GLU27
J	GLU62
J	HIS65
J	GLN141
J	HOH316
J	HOH396

site_id	DC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG J 202

Chain	Residue
J	HOH368
J	HOH378
J	HOH380
K	HOH360
L	HOH367
L	HOH379

site_id	DC5
Number of Residues	9
Details	BINDING SITE FOR RESIDUE MG K 201

Chain	Residue
J	ASP131
J	HOH365
J	HOH394
K	ASP131
K	GLU134
L	ASP131
L	GLU134
L	HOH335
L	HOH336

site_id	DC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG K 202

Chain	Residue
K	GLU27
K	GLU62
K	HIS65
K	GLN141
K	HOH349
K	HOH408

site_id	DC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE GOL K 203

Chain	Residue
H	GLU67
K	SER38
K	ASP42
K	HOH343

site_id	DC8
Number of Residues	7
Details	BINDING SITE FOR RESIDUE GOL K 204

Chain	Residue
H	SER38
H	CYS39
H	ASP42
K	GLU67
K	MET70
K	LYS71
K	HOH384

site_id	DC9
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG L 201

Chain	Residue
L	GLU27
L	GLU62
L	HIS65
L	GLN141
L	HOH360
L	HOH361

site_id	EC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE GOL L 202

Chain	Residue
G	GLU67
G	HOH394
L	SER38
L	LEU56

site_id	EC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE GOL L 203

Chain	Residue
G	SER38
G	CYS39
G	ASP42
G	HOH357
L	GLU67
L	LYS71

Functional Information from PROSITE/UniProt

site_id	PS00204
Number of Residues	21
Details	FERRITIN_2 Ferritin iron-binding regions signature 2. DphLCDFIEtyYLseqvksIK

Chain	Residue	Details
A	ASP126-LYS146

site_id	PS00540
Number of Residues	19
Details	FERRITIN_1 Ferritin iron-binding regions signature 1. EeREhaEKLMklQNqRgGR

Chain	Residue	Details
A	GLU61-ARG79

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1788
Details	Domain: {"description":"Ferritin-like diiron","evidences":[{"source":"PROSITE-ProRule","id":"PRU00085","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	60
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00085","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)