Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

3WBZ

Crystal structure of C. albicans tRNA(His) guanylyltransferase (Thg1) with ATP

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000287	molecular_function	magnesium ion binding
A	0006400	biological_process	tRNA modification
A	0008193	molecular_function	tRNA guanylyltransferase activity
B	0000287	molecular_function	magnesium ion binding
B	0006400	biological_process	tRNA modification
B	0008193	molecular_function	tRNA guanylyltransferase activity
C	0000287	molecular_function	magnesium ion binding
C	0006400	biological_process	tRNA modification
C	0008193	molecular_function	tRNA guanylyltransferase activity
D	0000287	molecular_function	magnesium ion binding
D	0006400	biological_process	tRNA modification
D	0008193	molecular_function	tRNA guanylyltransferase activity
E	0000287	molecular_function	magnesium ion binding
E	0006400	biological_process	tRNA modification
E	0008193	molecular_function	tRNA guanylyltransferase activity
F	0000287	molecular_function	magnesium ion binding
F	0006400	biological_process	tRNA modification
F	0008193	molecular_function	tRNA guanylyltransferase activity
G	0000287	molecular_function	magnesium ion binding
G	0006400	biological_process	tRNA modification
G	0008193	molecular_function	tRNA guanylyltransferase activity
H	0000287	molecular_function	magnesium ion binding
H	0006400	biological_process	tRNA modification
H	0008193	molecular_function	tRNA guanylyltransferase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	23
Details	BINDING SITE FOR RESIDUE ATP A 401

Chain	Residue
A	ASP29
A	PRO45
A	ASP47
A	LEU51
A	ASP76
A	MG403
A	MG404
A	HOH515
A	HOH520
A	HOH522
A	HOH528
A	GLY30
A	HOH553
A	HOH554
A	HOH555
A	HOH556
A	LYS31
A	GLY32
A	PHE33
A	HIS34
A	SER37
A	GLU43
A	LYS44

site_id	AC2
Number of Residues	17
Details	BINDING SITE FOR RESIDUE ATP A 402

Chain	Residue
A	ARG27
A	ARG132
A	TRP148
A	ARG149
A	ASP152
A	MG405
A	HOH515
A	HOH516
A	HOH517
A	HOH544
A	HOH555
A	HOH556
A	HOH557
B	LYS10
B	ARG92
B	LYS95
B	HOH538

site_id	AC3
Number of Residues	7
Details	BINDING SITE FOR RESIDUE MG A 403

Chain	Residue
A	ASP29
A	ASP76
A	ATP401
A	MG404
A	HOH532
A	HOH553
A	HOH554

site_id	AC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG A 404

Chain	Residue
A	ASP29
A	GLY30
A	ASP76
A	ATP401
A	MG403

site_id	AC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MG A 405

Chain	Residue
A	ATP402
A	HOH544
A	HOH555
A	HOH556

site_id	AC6
Number of Residues	24
Details	BINDING SITE FOR RESIDUE ATP B 401

Chain	Residue
B	ASP29
B	GLY30
B	LYS31
B	GLY32
B	PHE33
B	HIS34
B	GLU43
B	LYS44
B	PRO45
B	ASN46
B	ASP47
B	ALA50
B	LEU51
B	ASP76
B	MG403
B	MG404
B	HOH515
B	HOH522
B	HOH531
B	HOH536
B	HOH543
B	HOH550
B	HOH551
B	HOH562

site_id	AC7
Number of Residues	11
Details	BINDING SITE FOR RESIDUE ATP B 402

Chain	Residue
A	LYS10
A	ARG92
A	LYS95
B	ARG27
B	ARG132
B	TRP148
B	ASP152
B	MG405
B	HOH529
B	HOH531
B	HOH551

site_id	AC8
Number of Residues	7
Details	BINDING SITE FOR RESIDUE MG B 403

Chain	Residue
B	ASP29
B	ASP76
B	ATP401
B	MG404
B	HOH536
B	HOH562
B	HOH563

site_id	AC9
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG B 404

Chain	Residue
B	GLY30
B	ASP76
B	ATP401
B	MG403
B	ASP29

site_id	BC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MG B 405

Chain	Residue
B	ATP402
B	HOH529
B	HOH550
B	HOH551

site_id	BC2
Number of Residues	23
Details	BINDING SITE FOR RESIDUE ATP C 401

Chain	Residue
C	ASP29
C	GLY30
C	GLY32
C	PHE33
C	HIS34
C	SER37
C	GLU43
C	LYS44
C	PRO45
C	ASN46
C	ASP47
C	LEU51
C	SER75
C	ASP76
C	MG403
C	MG404
C	HOH517
C	HOH520
C	HOH532
C	HOH533
C	HOH546
C	HOH548
C	HOH549

site_id	BC3
Number of Residues	18
Details	BINDING SITE FOR RESIDUE ATP C 402

Chain	Residue
C	ARG27
C	ARG132
C	TRP148
C	ARG149
C	ASP152
C	MG405
C	HOH512
C	HOH522
C	HOH524
C	HOH530
C	HOH532
C	HOH533
C	HOH536
C	HOH540
C	HOH546
D	LYS10
D	ARG92
D	LYS95

site_id	BC4
Number of Residues	7
Details	BINDING SITE FOR RESIDUE MG C 403

Chain	Residue
C	ASP29
C	ASP76
C	ATP401
C	MG404
C	HOH535
C	HOH548
C	HOH549

site_id	BC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG C 404

Chain	Residue
C	ASP29
C	GLY30
C	ASP76
C	ATP401
C	MG403

site_id	BC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MG C 405

Chain	Residue
C	ATP402
C	HOH532
C	HOH533
C	HOH540

site_id	BC7
Number of Residues	21
Details	BINDING SITE FOR RESIDUE ATP D 401

Chain	Residue
D	ASP29
D	GLY30
D	LYS31
D	GLY32
D	PHE33
D	HIS34
D	GLU43
D	LYS44
D	PRO45
D	ASP47
D	ALA50
D	LEU51
D	ASP76
D	MG403
D	MG404
D	HOH509
D	HOH510
D	HOH524
D	HOH533
D	HOH534
D	HOH541

site_id	BC8
Number of Residues	15
Details	BINDING SITE FOR RESIDUE ATP D 402

Chain	Residue
C	LYS10
C	ARG92
C	LYS95
D	ARG27
D	ARG132
D	TRP148
D	ARG149
D	ASP152
D	MG405
D	HOH515
D	HOH532
D	HOH533
D	HOH534
D	HOH535
D	HOH537

site_id	BC9
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG D 403

Chain	Residue
D	ASP29
D	ASP76
D	ATP401
D	HOH524
D	HOH541
D	HOH542

site_id	CC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MG D 404

Chain	Residue
D	ASP29
D	GLY30
D	ASP76
D	ATP401

site_id	CC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MG D 405

Chain	Residue
D	ATP402
D	HOH532
D	HOH533
D	HOH534

site_id	CC3
Number of Residues	24
Details	BINDING SITE FOR RESIDUE ATP E 401

Chain	Residue
E	ASP29
E	GLY30
E	LYS31
E	GLY32
E	PHE33
E	HIS34
E	SER37
E	GLU43
E	LYS44
E	PRO45
E	ASN46
E	ASP47
E	LEU51
E	ASP76
E	MG403
E	MG404
E	HOH511
E	HOH512
E	HOH518
E	HOH521
E	HOH522
E	HOH536
E	HOH547
E	HOH550

site_id	CC4
Number of Residues	15
Details	BINDING SITE FOR RESIDUE ATP E 402

Chain	Residue
E	ARG27
E	ARG132
E	TRP148
E	ASP152
E	MG405
E	HOH509
E	HOH515
E	HOH518
E	HOH536
E	HOH546
E	HOH550
E	HOH551
F	LYS10
F	ARG92
F	LYS95

site_id	CC5
Number of Residues	7
Details	BINDING SITE FOR RESIDUE MG E 403

Chain	Residue
E	ASP29
E	ASP76
E	ATP401
E	MG404
E	HOH547
E	HOH548
E	HOH549

site_id	CC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG E 404

Chain	Residue
E	ASP29
E	GLY30
E	ASP76
E	ATP401
E	MG403

site_id	CC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MG E 405

Chain	Residue
E	ATP402
E	HOH536
E	HOH550
E	HOH551

site_id	CC8
Number of Residues	24
Details	BINDING SITE FOR RESIDUE ATP F 401

Chain	Residue
F	ASP29
F	GLY30
F	LYS31
F	GLY32
F	PHE33
F	HIS34
F	SER37
F	PHE42
F	GLU43
F	LYS44
F	PRO45
F	ASP47
F	LEU51
F	SER75
F	ASP76
F	MG403
F	MG404
F	HOH508
F	HOH512
F	HOH513
F	HOH514
F	HOH533
F	HOH535
F	HOH537

site_id	CC9
Number of Residues	15
Details	BINDING SITE FOR RESIDUE ATP F 402

Chain	Residue
E	LYS10
E	ARG92
E	LYS95
F	ARG27
F	ARG132
F	TRP148
F	ARG149
F	ASP152
F	MG405
F	HOH511
F	HOH514
F	HOH535
F	HOH536
F	HOH537
F	HOH538

site_id	DC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG F 403

Chain	Residue
F	ASP29
F	ASP76
F	ATP401
F	MG404
F	HOH533
F	HOH534

site_id	DC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG F 404

Chain	Residue
F	ASP29
F	GLY30
F	ASP76
F	ATP401
F	MG403

site_id	DC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MG F 405

Chain	Residue
F	ATP402
F	HOH535
F	HOH536
F	HOH537

site_id	DC4
Number of Residues	21
Details	BINDING SITE FOR RESIDUE ATP G 401

Chain	Residue
G	ASP29
G	GLY30
G	LYS31
G	GLY32
G	PHE33
G	HIS34
G	SER37
G	GLU43
G	LYS44
G	PRO45
G	ASN46
G	ASP47
G	LEU51
G	SER75
G	ASP76
G	MG403
G	MG404
G	HOH514
G	HOH517
G	HOH519
G	HOH521

site_id	DC5
Number of Residues	11
Details	BINDING SITE FOR RESIDUE ATP G 402

Chain	Residue
G	ARG27
G	ARG132
G	TRP148
G	ASP152
G	MG405
G	HOH519
G	HOH520
G	HOH521
H	LYS10
H	ARG92
H	LYS95

site_id	DC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG G 403

Chain	Residue
G	ASP29
G	ASP76
G	ATP401
G	MG404
G	HOH517
G	HOH518

site_id	DC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG G 404

Chain	Residue
G	ASP29
G	GLY30
G	ASP76
G	ATP401
G	MG403

site_id	DC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MG G 405

Chain	Residue
G	ATP402
G	HOH519
G	HOH520
G	HOH521

site_id	DC9
Number of Residues	21
Details	BINDING SITE FOR RESIDUE ATP H 401

Chain	Residue
H	ASP29
H	GLY30
H	LYS31
H	GLY32
H	PHE33
H	HIS34
H	GLU43
H	LYS44
H	PRO45
H	ASN46
H	ASP47
H	ALA50
H	LEU51
H	SER75
H	ASP76
H	MG403
H	MG404
H	HOH510
H	HOH521
H	HOH522
H	HOH524

site_id	EC1
Number of Residues	14
Details	BINDING SITE FOR RESIDUE ATP H 402

Chain	Residue
G	GLU7
G	LYS10
G	ARG92
G	LYS95
H	ARG27
H	ARG132
H	TRP148
H	ARG149
H	MG405
H	HOH508
H	HOH517
H	HOH522
H	HOH523
H	HOH524

site_id	EC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG H 403

Chain	Residue
H	ASP29
H	ASP76
H	ATP401
H	HOH520
H	HOH521

site_id	EC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MG H 404

Chain	Residue
H	ASP29
H	GLY30
H	ASP76
H	ATP401

site_id	EC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MG H 405

Chain	Residue
H	ATP402
H	HOH522
H	HOH523
H	HOH524

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)