3W81

Human alpha-l-iduronidase

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004553	molecular_function	hydrolase activity, hydrolyzing O-glycosyl compounds
A	0005975	biological_process	carbohydrate metabolic process
B	0004553	molecular_function	hydrolase activity, hydrolyzing O-glycosyl compounds
B	0005975	biological_process	carbohydrate metabolic process

Functional Information from PROSITE/UniProt

site_id	PS01027
Number of Residues	10
Details	GLYCOSYL_HYDROL_F39 Glycosyl hydrolases family 39 active site. WnFEtWNEPD

Chain	Residue	Details
A	TRP175-ASP184

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	ACT_SITE: Proton donor => ECO:0000255|PROSITE-ProRule:PRU10068, ECO:0000269|PubMed:24036510

Chain	Residue	Details
A	GLU182
B	GLU182

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site_id	SWS_FT_FI2
Number of Residues	2
Details	ACT_SITE: Nucleophile => ECO:0000269|PubMed:24036510

Chain	Residue	Details
A	GLU299
B	GLU299

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site_id	SWS_FT_FI3
Number of Residues	6
Details	BINDING: BINDING => ECO:0000269|PubMed:23959878, ECO:0000269|PubMed:24036510, ECO:0007744|PDB:3W81, ECO:0007744|PDB:3W82, ECO:0007744|PDB:4KGL

Chain	Residue	Details
A	PRO54
A	LEU56
A	HIS58
B	PRO54
B	LEU56
B	HIS58

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site_id	SWS_FT_FI4
Number of Residues	16
Details	BINDING: BINDING => ECO:0000269|PubMed:23959878, ECO:0007744|PDB:3W82

Chain	Residue	Details
A	HIS91
B	ASN181
B	GLU182
B	LYS264
B	GLU299
B	GLY305
B	ASP349
B	ARG363
A	ASN181
A	GLU182
A	LYS264
A	GLU299
A	GLY305
A	ASP349
A	ARG363
B	HIS91

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site_id	SWS_FT_FI5
Number of Residues	2
Details	BINDING: BINDING => ECO:0000269|PubMed:23959878, ECO:0000269|PubMed:24036510, ECO:0007744|PDB:3W81, ECO:0007744|PDB:3W82, ECO:0007744|PDB:4KGJ, ECO:0007744|PDB:4KH2

Chain	Residue	Details
A	TRP306
B	TRP306

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site_id	SWS_FT_FI6
Number of Residues	4
Details	BINDING: BINDING => ECO:0000269|PubMed:23959878, ECO:0007744|PDB:3W81, ECO:0007744|PDB:3W82

Chain	Residue	Details
A	ARG488
A	ARG492
B	ARG488
B	ARG492

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site_id	SWS_FT_FI7
Number of Residues	2
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:23959878, ECO:0000269|PubMed:24036510, ECO:0007744|PDB:3W81, ECO:0007744|PDB:3W82, ECO:0007744|PDB:4KGJ, ECO:0007744|PDB:4KGL, ECO:0007744|PDB:4KH2, ECO:0007744|PDB:4MJ2, ECO:0007744|PDB:4MJ4

Chain	Residue	Details
A	ASN110
B	ASN110

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site_id	SWS_FT_FI8
Number of Residues	2
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:23959878, ECO:0007744|PDB:3W81, ECO:0007744|PDB:3W82

Chain	Residue	Details
A	ASN190
B	ASN190

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site_id	SWS_FT_FI9
Number of Residues	2
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255|PROSITE-ProRule:PRU00498

Chain	Residue	Details
A	ASN336
B	ASN336

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site_id	SWS_FT_FI10
Number of Residues	4
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:23959878, ECO:0000269|PubMed:24036510, ECO:0007744|PDB:3W81, ECO:0007744|PDB:3W82, ECO:0007744|PDB:4KGJ, ECO:0007744|PDB:4KGL, ECO:0007744|PDB:4KH2, ECO:0007744|PDB:4MJ2, ECO:0007744|PDB:4MJ4

Chain	Residue	Details
A	ASN372
A	ASN415
B	ASN372
B	ASN415

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site_id	SWS_FT_FI11
Number of Residues	2
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:23959878, ECO:0007744|PDB:3W81

Chain	Residue	Details
A	ASN451
B	ASN451

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