3W3Z
Crystal structure of Kap121p bound to RanGTP
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005634 | cellular_component | nucleus |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0006406 | biological_process | mRNA export from nucleus |
| A | 0006606 | biological_process | protein import into nucleus |
| A | 0007088 | biological_process | regulation of mitotic nuclear division |
| A | 0008139 | molecular_function | nuclear localization sequence binding |
| A | 0015031 | biological_process | protein transport |
| A | 0060188 | biological_process | regulation of protein desumoylation |
| A | 0061608 | molecular_function | nuclear import signal receptor activity |
| B | 0003924 | molecular_function | GTPase activity |
| B | 0005525 | molecular_function | GTP binding |
| B | 0006913 | biological_process | nucleocytoplasmic transport |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MG B 201 |
| Chain | Residue |
| B | THR24 |
| B | THR42 |
| B | GTP202 |
| B | HOH302 |
| B | HOH303 |
| site_id | AC2 |
| Number of Residues | 26 |
| Details | BINDING SITE FOR RESIDUE GTP B 202 |
| Chain | Residue |
| B | LYS23 |
| B | THR24 |
| B | THR25 |
| B | PHE35 |
| B | GLU36 |
| B | LYS37 |
| B | LYS38 |
| B | TYR39 |
| B | ALA41 |
| B | THR42 |
| B | ALA67 |
| B | GLY68 |
| B | ASN122 |
| B | LYS123 |
| B | ASP125 |
| B | ILE126 |
| B | SER150 |
| B | ALA151 |
| B | LYS152 |
| B | MG201 |
| B | HOH302 |
| B | HOH303 |
| B | GLY19 |
| B | GLY20 |
| B | THR21 |
| B | GLY22 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 3 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:15602554, ECO:0000269|PubMed:15864302, ECO:0000269|PubMed:19965479, ECO:0000269|PubMed:9533885, ECO:0000269|PubMed:9878368, ECO:0007744|PDB:1BYU, ECO:0007744|PDB:1WA5, ECO:0007744|PDB:2BKU, ECO:0007744|PDB:3A6P, ECO:0007744|PDB:3RAN, ECO:0007744|PDB:3W3Z, ECO:0007744|PDB:5BXQ |
| Chain | Residue | Details |
| B | ASP18 | |
| B | ASN122 | |
| B | SER150 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:15602554, ECO:0000269|PubMed:15864302, ECO:0000269|PubMed:19965479, ECO:0007744|PDB:1WA5, ECO:0007744|PDB:2BKU, ECO:0007744|PDB:3A6P, ECO:0007744|PDB:3W3Z |
| Chain | Residue | Details |
| B | GLU36 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:15602554, ECO:0000269|PubMed:15864302, ECO:0000269|PubMed:19965479, ECO:0007744|PDB:1WA5, ECO:0007744|PDB:2BKU, ECO:0007744|PDB:3W3Z |
| Chain | Residue | Details |
| B | GLY68 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | SITE: Essential for GTP hydrolysis => ECO:0000250|UniProtKB:P62826 |
| Chain | Residue | Details |
| B | GLN69 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | MOD_RES: N-acetylalanine => ECO:0000250|UniProtKB:P62826 |
| Chain | Residue | Details |
| B | ALA2 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:P62826 |
| Chain | Residue | Details |
| B | THR24 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 4 |
| Details | MOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:P62826 |
| Chain | Residue | Details |
| B | LYS37 | |
| B | LYS60 | |
| B | LYS99 | |
| B | LYS134 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 1 |
| Details | MOD_RES: N6-acetyllysine; alternate => ECO:0000250|UniProtKB:P62826 |
| Chain | Residue | Details |
| B | LYS71 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 1 |
| Details | MOD_RES: N6-succinyllysine; alternate => ECO:0000250|UniProtKB:P62827 |
| Chain | Residue | Details |
| B | LYS159 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 1 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate => ECO:0000250|UniProtKB:P62826 |
| Chain | Residue | Details |
| B | LYS71 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 2 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0000250|UniProtKB:P62826 |
| Chain | Residue | Details |
| B | LYS152 |
