3W2Y

Crystal structure of DNA uridine endonuclease Mth212 mutant W205S

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003677	molecular_function	DNA binding
A	0003824	molecular_function	catalytic activity
A	0003906	molecular_function	DNA-(apurinic or apyrimidinic site) endonuclease activity
A	0004518	molecular_function	nuclease activity
A	0004519	molecular_function	endonuclease activity
A	0006281	biological_process	DNA repair
A	0006284	biological_process	base-excision repair
A	0008081	molecular_function	phosphoric diester hydrolase activity
A	0008311	molecular_function	double-stranded DNA 3'-5' DNA exonuclease activity
A	0016787	molecular_function	hydrolase activity
A	0016829	molecular_function	lyase activity
A	0046872	molecular_function	metal ion binding
A	0140078	molecular_function	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
D	0003677	molecular_function	DNA binding
D	0003824	molecular_function	catalytic activity
D	0003906	molecular_function	DNA-(apurinic or apyrimidinic site) endonuclease activity
D	0004518	molecular_function	nuclease activity
D	0004519	molecular_function	endonuclease activity
D	0006281	biological_process	DNA repair
D	0006284	biological_process	base-excision repair
D	0008081	molecular_function	phosphoric diester hydrolase activity
D	0008311	molecular_function	double-stranded DNA 3'-5' DNA exonuclease activity
D	0016787	molecular_function	hydrolase activity
D	0016829	molecular_function	lyase activity
D	0046872	molecular_function	metal ion binding
D	0140078	molecular_function	class I DNA-(apurinic or apyrimidinic site) endonuclease activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG A 301

Chain	Residue
A	ASN12
A	GLU38
A	HOH411
A	HOH468
A	HOH509
A	HOH590

---

site_id	AC2
Number of Residues	2
Details	BINDING SITE FOR RESIDUE FMT A 302

Chain	Residue
A	PHE86
A	HOH594

---

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE FMT A 303

Chain	Residue
A	ASN187
A	HOH495
D	GLN45
A	LYS183

---

site_id	AC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE FMT A 304

Chain	Residue
A	PRO43
A	PHE59
A	PHE60
A	GLU214
A	HOH431
A	HOH558

---

site_id	AC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE FMT A 305

Chain	Residue
A	GLU158
A	ARG178
A	HOH613
D	ASN114
D	LYS116

---

site_id	AC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE FMT A 306

Chain	Residue
A	ARG236
A	HOH447
A	HOH614

---

site_id	AC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE PEG A 308

Chain	Residue
A	LYS116
A	ASN153
A	SER171
A	TRP219
A	HOH413
A	HOH579

---

site_id	AC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE FMT A 309

Chain	Residue
A	TYR208
A	MET244
A	GLY245
A	SER246

---

site_id	AC9
Number of Residues	4
Details	BINDING SITE FOR RESIDUE PEG A 310

Chain	Residue
A	ARG194
A	MET195
A	PHE196
A	SER198

---

site_id	BC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE FMT A 311

Chain	Residue
A	LYS40
A	TYR68
A	SER69
A	TYR111

---

site_id	BC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE FMT A 312

Chain	Residue
A	ARG163
A	ASN167
A	TRP219
A	HOH435
A	HOH479

---

site_id	BC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE FMT A 313

Chain	Residue
A	HIS156
A	ARG157
A	ILE185
A	HOH430
A	HOH456
A	HOH581

---

site_id	BC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG D 301

Chain	Residue
D	ASN12
D	GLU38
D	HOH407
D	HOH425
D	HOH430
D	HOH449

---

site_id	BC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE FMT D 302

Chain	Residue
D	ARG157
D	GLU158
D	ILE159
D	ARG178
D	HOH525
D	HOH535

---

site_id	BC6
Number of Residues	2
Details	BINDING SITE FOR RESIDUE FMT D 303

Chain	Residue
D	MET195
D	SER198

---

Functional Information from PROSITE/UniProt

site_id	PS00726
Number of Residues	10
Details	AP_NUCLEASE_F1_1 AP endonucleases family 1 signature 1. PDILCLQEIK

Chain	Residue	Details
A	PRO31-LYS40

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	ACT_SITE: Proton donor/acceptor => ECO:0000305|PubMed:20434457

Chain	Residue	Details
A	ASP151
D	ASP151

---

site_id	SWS_FT_FI2
Number of Residues	4
Details	BINDING: BINDING => ECO:0000269|PubMed:20434457, ECO:0000269|Ref.7

Chain	Residue	Details
A	ASN12
A	GLU38
D	ASN12
D	GLU38

---

site_id	SWS_FT_FI3
Number of Residues	6
Details	BINDING: BINDING => ECO:0000269|PubMed:20434457

Chain	Residue	Details
A	ASP151
A	ASN153
A	HIS248
D	ASP151
D	ASN153
D	HIS248

---