3W15

Structure of peroxisomal targeting signal 2 (PTS2) of Saccharomyces cerevisiae 3-ketoacyl-CoA thiolase in complex with Pex7p and Pex21p

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005053	molecular_function	peroxisome matrix targeting signal-2 binding
A	0005515	molecular_function	protein binding
A	0005737	cellular_component	cytoplasm
A	0005777	cellular_component	peroxisome
A	0005778	cellular_component	peroxisomal membrane
A	0005782	cellular_component	peroxisomal matrix
A	0005829	cellular_component	cytosol
A	0015031	biological_process	protein transport
A	0016558	biological_process	protein import into peroxisome matrix
A	0016560	biological_process	protein import into peroxisome matrix, docking
A	0072663	biological_process	establishment of protein localization to peroxisome
C	0005515	molecular_function	protein binding
C	0006974	biological_process	DNA damage response
C	0008643	biological_process	carbohydrate transport
C	0015144	molecular_function	carbohydrate transmembrane transporter activity
C	0015768	biological_process	maltose transport
C	0016020	cellular_component	membrane
C	0030288	cellular_component	outer membrane-bounded periplasmic space
C	0034219	biological_process	carbohydrate transmembrane transport
C	0034289	biological_process	detection of maltose stimulus
C	0042597	cellular_component	periplasmic space
C	0042956	biological_process	maltodextrin transmembrane transport
C	0043190	cellular_component	ATP-binding cassette (ABC) transporter complex
C	0055052	cellular_component	ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing
C	0055085	biological_process	transmembrane transport
C	0060326	biological_process	cell chemotaxis
C	1901982	molecular_function	maltose binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE NO3 A 401

Chain	Residue
A	GLU149
A	TYR198
A	LEU216
C	ASP58
C	LYS63

---

site_id	AC2
Number of Residues	7
Details	BINDING SITE FOR RESIDUE NO3 A 402

Chain	Residue
A	THR90
A	HOH617
A	HOH620
A	ARG23
A	ILE42
A	VAL54
A	ASN55

---

site_id	AC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG A 403

Chain	Residue
A	ASP65
A	LEU66
A	CYS110
A	ASN111
A	HOH506
A	HOH508

---

site_id	AC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE NO3 B 301

Chain	Residue
B	HIS283
B	LYS284
B	ILE286

---

site_id	AC5
Number of Residues	7
Details	BINDING SITE FOR RESIDUE NO3 C 401

Chain	Residue
C	ASN29
C	LYS32
C	TRP79
C	ALA80
C	LEU279
C	HOH512
C	HOH728

---

site_id	AC6
Number of Residues	7
Details	BINDING SITE FOR RESIDUE NO3 C 402

Chain	Residue
C	TYR259
C	GLY260
C	VAL261
C	PRO332
C	ARG333
C	HOH681
C	HOH771

---

site_id	AC7
Number of Residues	8
Details	BINDING SITE FOR RESIDUE NO3 C 403

Chain	Residue
C	TYR184
C	ALA185
C	PHE186
C	PHE275
C	GLU345
C	PRO348
C	HOH601
C	HOH688

---

site_id	AC8
Number of Residues	7
Details	BINDING SITE FOR RESIDUE NO3 C 404

Chain	Residue
C	LYS157
C	LYS219
C	HIS220
C	MET221
C	ASN222
C	HOH591
C	HOH708

---

site_id	AC9
Number of Residues	5
Details	BINDING SITE FOR RESIDUE NO3 C 405

Chain	Residue
C	PRO246
C	TRP249
C	PRO315
C	GLY317
C	HOH648

---

site_id	BC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE NO3 C 406

Chain	Residue
C	ASN29
C	GLY30
C	ASP31
C	HOH775
C	HOH865

---

site_id	BC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG C 407

Chain	Residue
C	HOH607
C	HOH608
C	HOH609
C	HOH610
C	HOH611
C	HOH612

---

site_id	BC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG C 408

Chain	Residue
C	ASP72
C	HOH504
C	HOH505
C	HOH506
C	HOH507
C	HOH508

---

site_id	BC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG C 409

Chain	Residue
C	HOH671
C	HOH672
C	HOH673
C	HOH674
C	HOH675
C	HOH744

---

site_id	BC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG C 410

Chain	Residue
C	ASP226
C	HOH633
C	HOH634
C	HOH635
C	HOH636
C	HOH637

---

site_id	BC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG C 411

Chain	Residue
C	HOH798
C	HOH865
C	HOH887
C	HOH888
C	HOH889

---

Functional Information from PROSITE/UniProt

site_id	PS00678
Number of Residues	15
Details	WD_REPEATS_1 Trp-Asp (WD) repeats signature. VATGgvDnAIRIWDI

Chain	Residue	Details
A	VAL236-ILE250
A	VAL359-GLY373

---

site_id	PS01037
Number of Residues	18
Details	SBP_BACTERIAL_1 Bacterial extracellular solute-binding proteins, family 1 signature. PIAvEalSLIYNkdlLpN

Chain	Residue	Details
C	PRO124-ASN141

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	31
Details	Repeat: {"description":"WD 1"}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	31
Details	Repeat: {"description":"WD 2"}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	31
Details	Repeat: {"description":"WD 4"}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	31
Details	Repeat: {"description":"WD 5"}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	32
Details	Repeat: {"description":"WD 6"}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	14
Details	Transit peptide: {"description":"Peroxisome","evidences":[{"source":"PubMed","id":"23812376","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	14
Details	Region: {"description":"PTS2-type peroxisomal targeting signal","evidences":[{"source":"PubMed","id":"23812376","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

Catalytic Information from CSA

site_id	MCSA1
Number of Residues
Details	M-CSA 77

Chain

Residue

Details

---