3W0N

Crystal structure of a thermostable mutant of aminoglycoside phosphotransferase APH(4)-Ia, ternary complex with AMP-PNP and hygromycin B

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0005524	molecular_function	ATP binding
A	0016301	molecular_function	kinase activity
A	0016740	molecular_function	transferase activity
A	0046677	biological_process	response to antibiotic

Functional Information from PDB Data

site_id	AC1
Number of Residues	18
Details

Chain	Residue
A	SER29
A	HOH539
A	HOH545
A	HOH557
A	HOH579
A	HOH581
A	HOH611
A	HOH652
A	HOH658
A	HOH672
A	ALA36
A	PRO75
A	ARG93
A	ARG94
A	ALA95
A	ASN202
A	HOH502
A	HOH530

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site_id	AC2
Number of Residues	21
Details

Chain	Residue
A	GLN101
A	ASP126
A	ASP198
A	SER201
A	ASN202
A	ASP216
A	GLU219
A	ASN231
A	TRP235
A	TRP238
A	LEU239
A	GLN273
A	ASP285
A	ANP401
A	HOH501
A	HOH502
A	HOH511
A	HOH550
A	HOH563
A	HOH637
A	HOH707

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	Active site: {"description":"Proton acceptor","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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