Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

3VZD

Crystal structure of Sphingosine Kinase 1 with inhibitor and ADP

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0000287	molecular_function	magnesium ion binding
A	0001568	biological_process	blood vessel development
A	0001727	molecular_function	lipid kinase activity
A	0003376	biological_process	sphingosine-1-phosphate receptor signaling pathway
A	0003677	molecular_function	DNA binding
A	0005515	molecular_function	protein binding
A	0005516	molecular_function	calmodulin binding
A	0005524	molecular_function	ATP binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005737	cellular_component	cytoplasm
A	0005768	cellular_component	endosome
A	0005829	cellular_component	cytosol
A	0005886	cellular_component	plasma membrane
A	0005905	cellular_component	clathrin-coated pit
A	0005929	cellular_component	cilium
A	0006473	biological_process	protein acetylation
A	0006629	biological_process	lipid metabolic process
A	0006670	biological_process	sphingosine metabolic process
A	0006954	biological_process	inflammatory response
A	0007420	biological_process	brain development
A	0008283	biological_process	cell population proliferation
A	0008284	biological_process	positive regulation of cell population proliferation
A	0008289	molecular_function	lipid binding
A	0008481	molecular_function	sphingosine kinase activity
A	0010008	cellular_component	endosome membrane
A	0010468	biological_process	regulation of gene expression
A	0010800	biological_process	positive regulation of peptidyl-threonine phosphorylation
A	0010803	biological_process	regulation of tumor necrosis factor-mediated signaling pathway
A	0016020	cellular_component	membrane
A	0016301	molecular_function	kinase activity
A	0016407	molecular_function	acetyltransferase activity
A	0016740	molecular_function	transferase activity
A	0017050	molecular_function	D-erythro-sphingosine kinase activity
A	0019722	biological_process	calcium-mediated signaling
A	0030100	biological_process	regulation of endocytosis
A	0030139	cellular_component	endocytic vesicle
A	0030148	biological_process	sphingolipid biosynthetic process
A	0030307	biological_process	positive regulation of cell growth
A	0030335	biological_process	positive regulation of cell migration
A	0031398	biological_process	positive regulation of protein ubiquitination
A	0031410	cellular_component	cytoplasmic vesicle
A	0031901	cellular_component	early endosome membrane
A	0032651	biological_process	regulation of interleukin-1 beta production
A	0032740	biological_process	positive regulation of interleukin-17 production
A	0034248	biological_process	regulation of amide metabolic process
A	0034612	biological_process	response to tumor necrosis factor
A	0035556	biological_process	intracellular signal transduction
A	0035924	biological_process	cellular response to vascular endothelial growth factor stimulus
A	0038036	molecular_function	sphingosine-1-phosphate receptor activity
A	0043066	biological_process	negative regulation of apoptotic process
A	0045202	cellular_component	synapse
A	0045766	biological_process	positive regulation of angiogenesis
A	0045840	biological_process	positive regulation of mitotic nuclear division
A	0045931	biological_process	positive regulation of mitotic cell cycle
A	0045987	biological_process	positive regulation of smooth muscle contraction
A	0046512	biological_process	sphingosine biosynthetic process
A	0046521	biological_process	sphingoid catabolic process
A	0046890	biological_process	regulation of lipid biosynthetic process
A	0048146	biological_process	positive regulation of fibroblast proliferation
A	0050764	biological_process	regulation of phagocytosis
A	0051049	biological_process	regulation of transport
A	0051092	biological_process	positive regulation of NF-kappaB transcription factor activity
A	0051239	biological_process	regulation of multicellular organismal process
A	0051721	molecular_function	protein phosphatase 2A binding
A	0070301	biological_process	cellular response to hydrogen peroxide
A	0071363	biological_process	cellular response to growth factor stimulus
A	0071897	biological_process	DNA biosynthetic process
A	0090520	biological_process	sphingolipid mediated signaling pathway
A	0098793	cellular_component	presynapse
A	0150077	biological_process	regulation of neuroinflammatory response
A	1900060	biological_process	negative regulation of ceramide biosynthetic process
A	1900745	biological_process	positive regulation of p38MAPK cascade
A	1901224	biological_process	positive regulation of non-canonical NF-kappaB signal transduction
A	1903978	biological_process	regulation of microglial cell activation
A	1905364	biological_process	regulation of endosomal vesicle fusion
B	0000166	molecular_function	nucleotide binding
B	0000287	molecular_function	magnesium ion binding
B	0001568	biological_process	blood vessel development
B	0001727	molecular_function	lipid kinase activity
B	0003376	biological_process	sphingosine-1-phosphate receptor signaling pathway
B	0003677	molecular_function	DNA binding
B	0005515	molecular_function	protein binding
B	0005516	molecular_function	calmodulin binding
B	0005524	molecular_function	ATP binding
B	0005634	cellular_component	nucleus
B	0005654	cellular_component	nucleoplasm
B	0005737	cellular_component	cytoplasm
B	0005768	cellular_component	endosome
B	0005829	cellular_component	cytosol
B	0005886	cellular_component	plasma membrane
B	0005905	cellular_component	clathrin-coated pit
B	0005929	cellular_component	cilium
B	0006473	biological_process	protein acetylation
B	0006629	biological_process	lipid metabolic process
B	0006670	biological_process	sphingosine metabolic process
B	0006954	biological_process	inflammatory response
B	0007420	biological_process	brain development
B	0008283	biological_process	cell population proliferation
B	0008284	biological_process	positive regulation of cell population proliferation
B	0008289	molecular_function	lipid binding
B	0008481	molecular_function	sphingosine kinase activity
B	0010008	cellular_component	endosome membrane
B	0010468	biological_process	regulation of gene expression
B	0010800	biological_process	positive regulation of peptidyl-threonine phosphorylation
B	0010803	biological_process	regulation of tumor necrosis factor-mediated signaling pathway
B	0016020	cellular_component	membrane
B	0016301	molecular_function	kinase activity
B	0016407	molecular_function	acetyltransferase activity
B	0016740	molecular_function	transferase activity
B	0017050	molecular_function	D-erythro-sphingosine kinase activity
B	0019722	biological_process	calcium-mediated signaling
B	0030100	biological_process	regulation of endocytosis
B	0030139	cellular_component	endocytic vesicle
B	0030148	biological_process	sphingolipid biosynthetic process
B	0030307	biological_process	positive regulation of cell growth
B	0030335	biological_process	positive regulation of cell migration
B	0031398	biological_process	positive regulation of protein ubiquitination
B	0031410	cellular_component	cytoplasmic vesicle
B	0031901	cellular_component	early endosome membrane
B	0032651	biological_process	regulation of interleukin-1 beta production
B	0032740	biological_process	positive regulation of interleukin-17 production
B	0034248	biological_process	regulation of amide metabolic process
B	0034612	biological_process	response to tumor necrosis factor
B	0035556	biological_process	intracellular signal transduction
B	0035924	biological_process	cellular response to vascular endothelial growth factor stimulus
B	0038036	molecular_function	sphingosine-1-phosphate receptor activity
B	0043066	biological_process	negative regulation of apoptotic process
B	0045202	cellular_component	synapse
B	0045766	biological_process	positive regulation of angiogenesis
B	0045840	biological_process	positive regulation of mitotic nuclear division
B	0045931	biological_process	positive regulation of mitotic cell cycle
B	0045987	biological_process	positive regulation of smooth muscle contraction
B	0046512	biological_process	sphingosine biosynthetic process
B	0046521	biological_process	sphingoid catabolic process
B	0046890	biological_process	regulation of lipid biosynthetic process
B	0048146	biological_process	positive regulation of fibroblast proliferation
B	0050764	biological_process	regulation of phagocytosis
B	0051049	biological_process	regulation of transport
B	0051092	biological_process	positive regulation of NF-kappaB transcription factor activity
B	0051239	biological_process	regulation of multicellular organismal process
B	0051721	molecular_function	protein phosphatase 2A binding
B	0070301	biological_process	cellular response to hydrogen peroxide
B	0071363	biological_process	cellular response to growth factor stimulus
B	0071897	biological_process	DNA biosynthetic process
B	0090520	biological_process	sphingolipid mediated signaling pathway
B	0098793	cellular_component	presynapse
B	0150077	biological_process	regulation of neuroinflammatory response
B	1900060	biological_process	negative regulation of ceramide biosynthetic process
B	1900745	biological_process	positive regulation of p38MAPK cascade
B	1901224	biological_process	positive regulation of non-canonical NF-kappaB signal transduction
B	1903978	biological_process	regulation of microglial cell activation
B	1905364	biological_process	regulation of endosomal vesicle fusion
C	0000166	molecular_function	nucleotide binding
C	0000287	molecular_function	magnesium ion binding
C	0001568	biological_process	blood vessel development
C	0001727	molecular_function	lipid kinase activity
C	0003376	biological_process	sphingosine-1-phosphate receptor signaling pathway
C	0003677	molecular_function	DNA binding
C	0005515	molecular_function	protein binding
C	0005516	molecular_function	calmodulin binding
C	0005524	molecular_function	ATP binding
C	0005634	cellular_component	nucleus
C	0005654	cellular_component	nucleoplasm
C	0005737	cellular_component	cytoplasm
C	0005768	cellular_component	endosome
C	0005829	cellular_component	cytosol
C	0005886	cellular_component	plasma membrane
C	0005905	cellular_component	clathrin-coated pit
C	0005929	cellular_component	cilium
C	0006473	biological_process	protein acetylation
C	0006629	biological_process	lipid metabolic process
C	0006670	biological_process	sphingosine metabolic process
C	0006954	biological_process	inflammatory response
C	0007420	biological_process	brain development
C	0008283	biological_process	cell population proliferation
C	0008284	biological_process	positive regulation of cell population proliferation
C	0008289	molecular_function	lipid binding
C	0008481	molecular_function	sphingosine kinase activity
C	0010008	cellular_component	endosome membrane
C	0010468	biological_process	regulation of gene expression
C	0010800	biological_process	positive regulation of peptidyl-threonine phosphorylation
C	0010803	biological_process	regulation of tumor necrosis factor-mediated signaling pathway
C	0016020	cellular_component	membrane
C	0016301	molecular_function	kinase activity
C	0016407	molecular_function	acetyltransferase activity
C	0016740	molecular_function	transferase activity
C	0017050	molecular_function	D-erythro-sphingosine kinase activity
C	0019722	biological_process	calcium-mediated signaling
C	0030100	biological_process	regulation of endocytosis
C	0030139	cellular_component	endocytic vesicle
C	0030148	biological_process	sphingolipid biosynthetic process
C	0030307	biological_process	positive regulation of cell growth
C	0030335	biological_process	positive regulation of cell migration
C	0031398	biological_process	positive regulation of protein ubiquitination
C	0031410	cellular_component	cytoplasmic vesicle
C	0031901	cellular_component	early endosome membrane
C	0032651	biological_process	regulation of interleukin-1 beta production
C	0032740	biological_process	positive regulation of interleukin-17 production
C	0034248	biological_process	regulation of amide metabolic process
C	0034612	biological_process	response to tumor necrosis factor
C	0035556	biological_process	intracellular signal transduction
C	0035924	biological_process	cellular response to vascular endothelial growth factor stimulus
C	0038036	molecular_function	sphingosine-1-phosphate receptor activity
C	0043066	biological_process	negative regulation of apoptotic process
C	0045202	cellular_component	synapse
C	0045766	biological_process	positive regulation of angiogenesis
C	0045840	biological_process	positive regulation of mitotic nuclear division
C	0045931	biological_process	positive regulation of mitotic cell cycle
C	0045987	biological_process	positive regulation of smooth muscle contraction
C	0046512	biological_process	sphingosine biosynthetic process
C	0046521	biological_process	sphingoid catabolic process
C	0046890	biological_process	regulation of lipid biosynthetic process
C	0048146	biological_process	positive regulation of fibroblast proliferation
C	0050764	biological_process	regulation of phagocytosis
C	0051049	biological_process	regulation of transport
C	0051092	biological_process	positive regulation of NF-kappaB transcription factor activity
C	0051239	biological_process	regulation of multicellular organismal process
C	0051721	molecular_function	protein phosphatase 2A binding
C	0070301	biological_process	cellular response to hydrogen peroxide
C	0071363	biological_process	cellular response to growth factor stimulus
C	0071897	biological_process	DNA biosynthetic process
C	0090520	biological_process	sphingolipid mediated signaling pathway
C	0098793	cellular_component	presynapse
C	0150077	biological_process	regulation of neuroinflammatory response
C	1900060	biological_process	negative regulation of ceramide biosynthetic process
C	1900745	biological_process	positive regulation of p38MAPK cascade
C	1901224	biological_process	positive regulation of non-canonical NF-kappaB signal transduction
C	1903978	biological_process	regulation of microglial cell activation
C	1905364	biological_process	regulation of endosomal vesicle fusion
D	0000166	molecular_function	nucleotide binding
D	0000287	molecular_function	magnesium ion binding
D	0001568	biological_process	blood vessel development
D	0001727	molecular_function	lipid kinase activity
D	0003376	biological_process	sphingosine-1-phosphate receptor signaling pathway
D	0003677	molecular_function	DNA binding
D	0005515	molecular_function	protein binding
D	0005516	molecular_function	calmodulin binding
D	0005524	molecular_function	ATP binding
D	0005634	cellular_component	nucleus
D	0005654	cellular_component	nucleoplasm
D	0005737	cellular_component	cytoplasm
D	0005768	cellular_component	endosome
D	0005829	cellular_component	cytosol
D	0005886	cellular_component	plasma membrane
D	0005905	cellular_component	clathrin-coated pit
D	0005929	cellular_component	cilium
D	0006473	biological_process	protein acetylation
D	0006629	biological_process	lipid metabolic process
D	0006670	biological_process	sphingosine metabolic process
D	0006954	biological_process	inflammatory response
D	0007420	biological_process	brain development
D	0008283	biological_process	cell population proliferation
D	0008284	biological_process	positive regulation of cell population proliferation
D	0008289	molecular_function	lipid binding
D	0008481	molecular_function	sphingosine kinase activity
D	0010008	cellular_component	endosome membrane
D	0010468	biological_process	regulation of gene expression
D	0010800	biological_process	positive regulation of peptidyl-threonine phosphorylation
D	0010803	biological_process	regulation of tumor necrosis factor-mediated signaling pathway
D	0016020	cellular_component	membrane
D	0016301	molecular_function	kinase activity
D	0016407	molecular_function	acetyltransferase activity
D	0016740	molecular_function	transferase activity
D	0017050	molecular_function	D-erythro-sphingosine kinase activity
D	0019722	biological_process	calcium-mediated signaling
D	0030100	biological_process	regulation of endocytosis
D	0030139	cellular_component	endocytic vesicle
D	0030148	biological_process	sphingolipid biosynthetic process
D	0030307	biological_process	positive regulation of cell growth
D	0030335	biological_process	positive regulation of cell migration
D	0031398	biological_process	positive regulation of protein ubiquitination
D	0031410	cellular_component	cytoplasmic vesicle
D	0031901	cellular_component	early endosome membrane
D	0032651	biological_process	regulation of interleukin-1 beta production
D	0032740	biological_process	positive regulation of interleukin-17 production
D	0034248	biological_process	regulation of amide metabolic process
D	0034612	biological_process	response to tumor necrosis factor
D	0035556	biological_process	intracellular signal transduction
D	0035924	biological_process	cellular response to vascular endothelial growth factor stimulus
D	0038036	molecular_function	sphingosine-1-phosphate receptor activity
D	0043066	biological_process	negative regulation of apoptotic process
D	0045202	cellular_component	synapse
D	0045766	biological_process	positive regulation of angiogenesis
D	0045840	biological_process	positive regulation of mitotic nuclear division
D	0045931	biological_process	positive regulation of mitotic cell cycle
D	0045987	biological_process	positive regulation of smooth muscle contraction
D	0046512	biological_process	sphingosine biosynthetic process
D	0046521	biological_process	sphingoid catabolic process
D	0046890	biological_process	regulation of lipid biosynthetic process
D	0048146	biological_process	positive regulation of fibroblast proliferation
D	0050764	biological_process	regulation of phagocytosis
D	0051049	biological_process	regulation of transport
D	0051092	biological_process	positive regulation of NF-kappaB transcription factor activity
D	0051239	biological_process	regulation of multicellular organismal process
D	0051721	molecular_function	protein phosphatase 2A binding
D	0070301	biological_process	cellular response to hydrogen peroxide
D	0071363	biological_process	cellular response to growth factor stimulus
D	0071897	biological_process	DNA biosynthetic process
D	0090520	biological_process	sphingolipid mediated signaling pathway
D	0098793	cellular_component	presynapse
D	0150077	biological_process	regulation of neuroinflammatory response
D	1900060	biological_process	negative regulation of ceramide biosynthetic process
D	1900745	biological_process	positive regulation of p38MAPK cascade
D	1901224	biological_process	positive regulation of non-canonical NF-kappaB signal transduction
D	1903978	biological_process	regulation of microglial cell activation
D	1905364	biological_process	regulation of endosomal vesicle fusion
E	0000166	molecular_function	nucleotide binding
E	0000287	molecular_function	magnesium ion binding
E	0001568	biological_process	blood vessel development
E	0001727	molecular_function	lipid kinase activity
E	0003376	biological_process	sphingosine-1-phosphate receptor signaling pathway
E	0003677	molecular_function	DNA binding
E	0005515	molecular_function	protein binding
E	0005516	molecular_function	calmodulin binding
E	0005524	molecular_function	ATP binding
E	0005634	cellular_component	nucleus
E	0005654	cellular_component	nucleoplasm
E	0005737	cellular_component	cytoplasm
E	0005768	cellular_component	endosome
E	0005829	cellular_component	cytosol
E	0005886	cellular_component	plasma membrane
E	0005905	cellular_component	clathrin-coated pit
E	0005929	cellular_component	cilium
E	0006473	biological_process	protein acetylation
E	0006629	biological_process	lipid metabolic process
E	0006670	biological_process	sphingosine metabolic process
E	0006954	biological_process	inflammatory response
E	0007420	biological_process	brain development
E	0008283	biological_process	cell population proliferation
E	0008284	biological_process	positive regulation of cell population proliferation
E	0008289	molecular_function	lipid binding
E	0008481	molecular_function	sphingosine kinase activity
E	0010008	cellular_component	endosome membrane
E	0010468	biological_process	regulation of gene expression
E	0010800	biological_process	positive regulation of peptidyl-threonine phosphorylation
E	0010803	biological_process	regulation of tumor necrosis factor-mediated signaling pathway
E	0016020	cellular_component	membrane
E	0016301	molecular_function	kinase activity
E	0016407	molecular_function	acetyltransferase activity
E	0016740	molecular_function	transferase activity
E	0017050	molecular_function	D-erythro-sphingosine kinase activity
E	0019722	biological_process	calcium-mediated signaling
E	0030100	biological_process	regulation of endocytosis
E	0030139	cellular_component	endocytic vesicle
E	0030148	biological_process	sphingolipid biosynthetic process
E	0030307	biological_process	positive regulation of cell growth
E	0030335	biological_process	positive regulation of cell migration
E	0031398	biological_process	positive regulation of protein ubiquitination
E	0031410	cellular_component	cytoplasmic vesicle
E	0031901	cellular_component	early endosome membrane
E	0032651	biological_process	regulation of interleukin-1 beta production
E	0032740	biological_process	positive regulation of interleukin-17 production
E	0034248	biological_process	regulation of amide metabolic process
E	0034612	biological_process	response to tumor necrosis factor
E	0035556	biological_process	intracellular signal transduction
E	0035924	biological_process	cellular response to vascular endothelial growth factor stimulus
E	0038036	molecular_function	sphingosine-1-phosphate receptor activity
E	0043066	biological_process	negative regulation of apoptotic process
E	0045202	cellular_component	synapse
E	0045766	biological_process	positive regulation of angiogenesis
E	0045840	biological_process	positive regulation of mitotic nuclear division
E	0045931	biological_process	positive regulation of mitotic cell cycle
E	0045987	biological_process	positive regulation of smooth muscle contraction
E	0046512	biological_process	sphingosine biosynthetic process
E	0046521	biological_process	sphingoid catabolic process
E	0046890	biological_process	regulation of lipid biosynthetic process
E	0048146	biological_process	positive regulation of fibroblast proliferation
E	0050764	biological_process	regulation of phagocytosis
E	0051049	biological_process	regulation of transport
E	0051092	biological_process	positive regulation of NF-kappaB transcription factor activity
E	0051239	biological_process	regulation of multicellular organismal process
E	0051721	molecular_function	protein phosphatase 2A binding
E	0070301	biological_process	cellular response to hydrogen peroxide
E	0071363	biological_process	cellular response to growth factor stimulus
E	0071897	biological_process	DNA biosynthetic process
E	0090520	biological_process	sphingolipid mediated signaling pathway
E	0098793	cellular_component	presynapse
E	0150077	biological_process	regulation of neuroinflammatory response
E	1900060	biological_process	negative regulation of ceramide biosynthetic process
E	1900745	biological_process	positive regulation of p38MAPK cascade
E	1901224	biological_process	positive regulation of non-canonical NF-kappaB signal transduction
E	1903978	biological_process	regulation of microglial cell activation
E	1905364	biological_process	regulation of endosomal vesicle fusion
F	0000166	molecular_function	nucleotide binding
F	0000287	molecular_function	magnesium ion binding
F	0001568	biological_process	blood vessel development
F	0001727	molecular_function	lipid kinase activity
F	0003376	biological_process	sphingosine-1-phosphate receptor signaling pathway
F	0003677	molecular_function	DNA binding
F	0005515	molecular_function	protein binding
F	0005516	molecular_function	calmodulin binding
F	0005524	molecular_function	ATP binding
F	0005634	cellular_component	nucleus
F	0005654	cellular_component	nucleoplasm
F	0005737	cellular_component	cytoplasm
F	0005768	cellular_component	endosome
F	0005829	cellular_component	cytosol
F	0005886	cellular_component	plasma membrane
F	0005905	cellular_component	clathrin-coated pit
F	0005929	cellular_component	cilium
F	0006473	biological_process	protein acetylation
F	0006629	biological_process	lipid metabolic process
F	0006670	biological_process	sphingosine metabolic process
F	0006954	biological_process	inflammatory response
F	0007420	biological_process	brain development
F	0008283	biological_process	cell population proliferation
F	0008284	biological_process	positive regulation of cell population proliferation
F	0008289	molecular_function	lipid binding
F	0008481	molecular_function	sphingosine kinase activity
F	0010008	cellular_component	endosome membrane
F	0010468	biological_process	regulation of gene expression
F	0010800	biological_process	positive regulation of peptidyl-threonine phosphorylation
F	0010803	biological_process	regulation of tumor necrosis factor-mediated signaling pathway
F	0016020	cellular_component	membrane
F	0016301	molecular_function	kinase activity
F	0016407	molecular_function	acetyltransferase activity
F	0016740	molecular_function	transferase activity
F	0017050	molecular_function	D-erythro-sphingosine kinase activity
F	0019722	biological_process	calcium-mediated signaling
F	0030100	biological_process	regulation of endocytosis
F	0030139	cellular_component	endocytic vesicle
F	0030148	biological_process	sphingolipid biosynthetic process
F	0030307	biological_process	positive regulation of cell growth
F	0030335	biological_process	positive regulation of cell migration
F	0031398	biological_process	positive regulation of protein ubiquitination
F	0031410	cellular_component	cytoplasmic vesicle
F	0031901	cellular_component	early endosome membrane
F	0032651	biological_process	regulation of interleukin-1 beta production
F	0032740	biological_process	positive regulation of interleukin-17 production
F	0034248	biological_process	regulation of amide metabolic process
F	0034612	biological_process	response to tumor necrosis factor
F	0035556	biological_process	intracellular signal transduction
F	0035924	biological_process	cellular response to vascular endothelial growth factor stimulus
F	0038036	molecular_function	sphingosine-1-phosphate receptor activity
F	0043066	biological_process	negative regulation of apoptotic process
F	0045202	cellular_component	synapse
F	0045766	biological_process	positive regulation of angiogenesis
F	0045840	biological_process	positive regulation of mitotic nuclear division
F	0045931	biological_process	positive regulation of mitotic cell cycle
F	0045987	biological_process	positive regulation of smooth muscle contraction
F	0046512	biological_process	sphingosine biosynthetic process
F	0046521	biological_process	sphingoid catabolic process
F	0046890	biological_process	regulation of lipid biosynthetic process
F	0048146	biological_process	positive regulation of fibroblast proliferation
F	0050764	biological_process	regulation of phagocytosis
F	0051049	biological_process	regulation of transport
F	0051092	biological_process	positive regulation of NF-kappaB transcription factor activity
F	0051239	biological_process	regulation of multicellular organismal process
F	0051721	molecular_function	protein phosphatase 2A binding
F	0070301	biological_process	cellular response to hydrogen peroxide
F	0071363	biological_process	cellular response to growth factor stimulus
F	0071897	biological_process	DNA biosynthetic process
F	0090520	biological_process	sphingolipid mediated signaling pathway
F	0098793	cellular_component	presynapse
F	0150077	biological_process	regulation of neuroinflammatory response
F	1900060	biological_process	negative regulation of ceramide biosynthetic process
F	1900745	biological_process	positive regulation of p38MAPK cascade
F	1901224	biological_process	positive regulation of non-canonical NF-kappaB signal transduction
F	1903978	biological_process	regulation of microglial cell activation
F	1905364	biological_process	regulation of endosomal vesicle fusion

Functional Information from PDB Data

site_id	AC1
Number of Residues	10
Details	BINDING SITE FOR RESIDUE UUL A 401

Chain	Residue
A	PHE173
A	PHE303
A	ILE174
A	VAL177
A	ASP178
A	PHE192
A	THR196
A	MET272
A	PHE288
A	LEU299

site_id	AC2
Number of Residues	8
Details	BINDING SITE FOR RESIDUE UUL A 402

Chain	Residue
A	PHE197
A	LEU200
A	ALA201
A	ARG296
A	ALA297
C	ALA201
E	PHE197
E	ALA201

site_id	AC3
Number of Residues	9
Details	BINDING SITE FOR RESIDUE UUL B 401

Chain	Residue
B	PHE173
B	ILE174
B	VAL177
B	ASP178
B	THR196
B	MET272
B	PHE288
B	PHE303
B	HIS311

site_id	AC4
Number of Residues	11
Details	BINDING SITE FOR RESIDUE POP B 402

Chain	Residue
B	SER79
B	GLY80
B	GLY82
B	LEU83
B	GLY111
B	SER112
B	GLY113
B	ARG185
B	ARG191
B	MG403
B	HOH551

site_id	AC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG B 403

Chain	Residue
B	GLY82
B	ASP341
B	GLY342
B	GLU343
B	POP402

site_id	AC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CL B 404

Chain	Residue
B	ARG16
B	SER48
B	PHE49
B	THR50
C	ARG56

site_id	AC7
Number of Residues	9
Details	BINDING SITE FOR RESIDUE UUL C 401

Chain	Residue
C	PHE173
C	ILE174
C	VAL177
C	ASP178
C	THR196
C	MET272
C	PHE288
C	PHE303
C	MET306

site_id	AC8
Number of Residues	18
Details	BINDING SITE FOR RESIDUE ADP C 402

Chain	Residue
C	ASN22
C	ARG24
C	THR54
C	GLU55
C	ARG56
C	SER79
C	GLY80
C	GLY82
C	LEU83
C	GLU86
C	GLY111
C	SER112
C	GLY113
C	ARG185
C	ARG191
C	GLU343
C	MG403
C	HOH531

site_id	AC9
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG C 403

Chain	Residue
C	GLY82
C	ASP341
C	GLY342
C	GLU343
C	ADP402

site_id	BC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CL C 404

Chain	Residue
B	ARG56
C	PHE49
C	THR50
C	TRP72

site_id	BC2
Number of Residues	11
Details	BINDING SITE FOR RESIDUE UUL D 500

Chain	Residue
D	PHE173
D	ILE174
D	VAL177
D	ASP178
D	PHE192
D	THR196
D	MET272
D	PHE288
D	PHE303
D	MET306
D	HIS311

site_id	BC3
Number of Residues	11
Details	BINDING SITE FOR RESIDUE UUL E 401

Chain	Residue
E	THR196
E	LEU268
E	MET272
E	PHE288
E	PHE303
E	MET306
E	HIS311
E	PHE173
E	VAL177
E	ASP178
E	PHE192

site_id	BC4
Number of Residues	17
Details	BINDING SITE FOR RESIDUE ADP E 402

Chain	Residue
E	ASN22
E	ARG24
E	THR54
E	GLU55
E	ARG56
E	ARG57
E	SER79
E	GLY80
E	GLY82
E	LEU83
E	GLU86
E	SER112
E	GLY113
E	ARG185
E	ARG191
E	GLU343
E	MG403

site_id	BC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG E 403

Chain	Residue
E	GLY82
E	ASP341
E	GLY342
E	GLU343
E	ADP402

site_id	BC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL E 404

Chain	Residue
E	SER48
E	PHE49
E	THR50

site_id	BC7
Number of Residues	11
Details	BINDING SITE FOR RESIDUE UUL F 500

Chain	Residue
F	ILE174
F	VAL177
F	ASP178
F	PHE192
F	THR196
F	MET272
F	PHE288
F	LEU299
F	PHE303
F	MET306
F	HIS311

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	6
Details	ACT_SITE: Proton donor/acceptor => ECO:0000269\|PubMed:23602659

Chain	Residue	Details
A	ASP81
B	ASP81
C	ASP81
D	ASP81
E	ASP81
F	ASP81

site_id	SWS_FT_FI2
Number of Residues	54
Details	BINDING: BINDING => ECO:0000269\|PubMed:23602659

Chain	Residue	Details
A	ASN22
B	ASN22
B	THR54
B	SER79
B	GLU86
B	GLY111
B	ASP178
B	ARG185
B	ARG191
B	ASP341
C	ASN22
A	THR54
C	THR54
C	SER79
C	GLU86
C	GLY111
C	ASP178
C	ARG185
C	ARG191
C	ASP341
D	ASN22
D	THR54
A	SER79
D	SER79
D	GLU86
D	GLY111
D	ASP178
D	ARG185
D	ARG191
D	ASP341
E	ASN22
E	THR54
E	SER79
A	GLU86
E	GLU86
E	GLY111
E	ASP178
E	ARG185
E	ARG191
E	ASP341
F	ASN22
F	THR54
F	SER79
F	GLU86
A	GLY111
F	GLY111
F	ASP178
F	ARG185
F	ARG191
F	ASP341
A	ASP178
A	ARG185
A	ARG191
A	ASP341

site_id	SWS_FT_FI3
Number of Residues	6
Details	MOD_RES: Phosphothreonine => ECO:0007744\|PubMed:18669648

Chain	Residue	Details
A	THR193
B	THR193
C	THR193
D	THR193
E	THR193
F	THR193

site_id	SWS_FT_FI4
Number of Residues	6
Details	MOD_RES: Phosphoserine => ECO:0000269\|PubMed:20577214

Chain	Residue	Details
A	SER225
B	SER225
C	SER225
D	SER225
E	SER225
F	SER225

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)