3VXG

Crystal structure of conjugated polyketone reductase C2 from Candida Parapsilosis

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004033	molecular_function	aldo-keto reductase (NADPH) activity
A	0005575	cellular_component	cellular_component
A	0016491	molecular_function	oxidoreductase activity
A	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
A	0016652	molecular_function	oxidoreductase activity, acting on NAD(P)H, NAD(P) as acceptor
A	0036441	molecular_function	2-dehydropantolactone reductase activity
A	0042180	biological_process	cellular ketone metabolic process
A	0044281	biological_process	small molecule metabolic process
A	0047011	molecular_function	2-dehydropantolactone reductase (A-specific) activity

Functional Information from PROSITE/UniProt

site_id	PS00422
Number of Residues	10
Details	GRANINS_1 Granins signature 1. ESLNLFDfEL

Chain	Residue	Details
A	GLU270-LEU279

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site_id	PS00798
Number of Residues	18
Details	ALDOKETO_REDUCTASE_1 Aldo/keto reductase family signature 1. GFRHIDTAeayntQkeVG

Chain	Residue	Details
A	GLY53-GLY70

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	ACT_SITE: Proton donor => ECO:0000305|PubMed:23828603

Chain	Residue	Details
A	HIS125
A	TYR63

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site_id	SWS_FT_FI2
Number of Residues	15
Details	BINDING: BINDING => ECO:0000269|PubMed:23828603, ECO:0007744|PDB:4H8N

Chain	Residue	Details
A	LYS28
A	ASP58
A	SER161
A	GLN186
A	SER215
A	LEU217
A	ARG222
A	THR260
A	THR261
A	SER262
A	SER263
A	LYS264
A	ARG267
A	THR27
A	GLY26

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site_id	SWS_FT_FI3
Number of Residues	1
Details	SITE: Lowers pKa of active site Tyr => ECO:0000305|PubMed:23828603

Chain	Residue	Details
A	LYS88

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