3VWU

Crystal structure of peroxiredoxin 4 from M. musculus

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004601	molecular_function	peroxidase activity
A	0005515	molecular_function	protein binding
A	0005615	cellular_component	extracellular space
A	0005737	cellular_component	cytoplasm
A	0005739	cellular_component	mitochondrion
A	0005783	cellular_component	endoplasmic reticulum
A	0005790	cellular_component	smooth endoplasmic reticulum
A	0005829	cellular_component	cytosol
A	0006979	biological_process	response to oxidative stress
A	0007283	biological_process	spermatogenesis
A	0008379	molecular_function	thioredoxin peroxidase activity
A	0008584	biological_process	male gonad development
A	0016209	molecular_function	antioxidant activity
A	0016491	molecular_function	oxidoreductase activity
A	0018401	biological_process	peptidyl-proline hydroxylation to 4-hydroxy-L-proline
A	0030198	biological_process	extracellular matrix organization
A	0042744	biological_process	hydrogen peroxide catabolic process
A	0042802	molecular_function	identical protein binding
A	0045454	biological_process	cell redox homeostasis
A	0051604	biological_process	protein maturation
A	0051920	molecular_function	peroxiredoxin activity
A	0060090	molecular_function	molecular adaptor activity
A	0072593	biological_process	reactive oxygen species metabolic process
A	0098869	biological_process	cellular oxidant detoxification
A	0140313	molecular_function	molecular sequestering activity
A	0140824	molecular_function	thioredoxin-dependent peroxiredoxin activity
A	2000255	biological_process	negative regulation of male germ cell proliferation
B	0004601	molecular_function	peroxidase activity
B	0005515	molecular_function	protein binding
B	0005615	cellular_component	extracellular space
B	0005737	cellular_component	cytoplasm
B	0005739	cellular_component	mitochondrion
B	0005783	cellular_component	endoplasmic reticulum
B	0005790	cellular_component	smooth endoplasmic reticulum
B	0005829	cellular_component	cytosol
B	0006979	biological_process	response to oxidative stress
B	0007283	biological_process	spermatogenesis
B	0008379	molecular_function	thioredoxin peroxidase activity
B	0008584	biological_process	male gonad development
B	0016209	molecular_function	antioxidant activity
B	0016491	molecular_function	oxidoreductase activity
B	0018401	biological_process	peptidyl-proline hydroxylation to 4-hydroxy-L-proline
B	0030198	biological_process	extracellular matrix organization
B	0042744	biological_process	hydrogen peroxide catabolic process
B	0042802	molecular_function	identical protein binding
B	0045454	biological_process	cell redox homeostasis
B	0051604	biological_process	protein maturation
B	0051920	molecular_function	peroxiredoxin activity
B	0060090	molecular_function	molecular adaptor activity
B	0072593	biological_process	reactive oxygen species metabolic process
B	0098869	biological_process	cellular oxidant detoxification
B	0140313	molecular_function	molecular sequestering activity
B	0140824	molecular_function	thioredoxin-dependent peroxiredoxin activity
B	2000255	biological_process	negative regulation of male germ cell proliferation
C	0004601	molecular_function	peroxidase activity
C	0005515	molecular_function	protein binding
C	0005615	cellular_component	extracellular space
C	0005737	cellular_component	cytoplasm
C	0005739	cellular_component	mitochondrion
C	0005783	cellular_component	endoplasmic reticulum
C	0005790	cellular_component	smooth endoplasmic reticulum
C	0005829	cellular_component	cytosol
C	0006979	biological_process	response to oxidative stress
C	0007283	biological_process	spermatogenesis
C	0008379	molecular_function	thioredoxin peroxidase activity
C	0008584	biological_process	male gonad development
C	0016209	molecular_function	antioxidant activity
C	0016491	molecular_function	oxidoreductase activity
C	0018401	biological_process	peptidyl-proline hydroxylation to 4-hydroxy-L-proline
C	0030198	biological_process	extracellular matrix organization
C	0042744	biological_process	hydrogen peroxide catabolic process
C	0042802	molecular_function	identical protein binding
C	0045454	biological_process	cell redox homeostasis
C	0051604	biological_process	protein maturation
C	0051920	molecular_function	peroxiredoxin activity
C	0060090	molecular_function	molecular adaptor activity
C	0072593	biological_process	reactive oxygen species metabolic process
C	0098869	biological_process	cellular oxidant detoxification
C	0140313	molecular_function	molecular sequestering activity
C	0140824	molecular_function	thioredoxin-dependent peroxiredoxin activity
C	2000255	biological_process	negative regulation of male germ cell proliferation
D	0004601	molecular_function	peroxidase activity
D	0005515	molecular_function	protein binding
D	0005615	cellular_component	extracellular space
D	0005737	cellular_component	cytoplasm
D	0005739	cellular_component	mitochondrion
D	0005783	cellular_component	endoplasmic reticulum
D	0005790	cellular_component	smooth endoplasmic reticulum
D	0005829	cellular_component	cytosol
D	0006979	biological_process	response to oxidative stress
D	0007283	biological_process	spermatogenesis
D	0008379	molecular_function	thioredoxin peroxidase activity
D	0008584	biological_process	male gonad development
D	0016209	molecular_function	antioxidant activity
D	0016491	molecular_function	oxidoreductase activity
D	0018401	biological_process	peptidyl-proline hydroxylation to 4-hydroxy-L-proline
D	0030198	biological_process	extracellular matrix organization
D	0042744	biological_process	hydrogen peroxide catabolic process
D	0042802	molecular_function	identical protein binding
D	0045454	biological_process	cell redox homeostasis
D	0051604	biological_process	protein maturation
D	0051920	molecular_function	peroxiredoxin activity
D	0060090	molecular_function	molecular adaptor activity
D	0072593	biological_process	reactive oxygen species metabolic process
D	0098869	biological_process	cellular oxidant detoxification
D	0140313	molecular_function	molecular sequestering activity
D	0140824	molecular_function	thioredoxin-dependent peroxiredoxin activity
D	2000255	biological_process	negative regulation of male germ cell proliferation
E	0004601	molecular_function	peroxidase activity
E	0005515	molecular_function	protein binding
E	0005615	cellular_component	extracellular space
E	0005737	cellular_component	cytoplasm
E	0005739	cellular_component	mitochondrion
E	0005783	cellular_component	endoplasmic reticulum
E	0005790	cellular_component	smooth endoplasmic reticulum
E	0005829	cellular_component	cytosol
E	0006979	biological_process	response to oxidative stress
E	0007283	biological_process	spermatogenesis
E	0008379	molecular_function	thioredoxin peroxidase activity
E	0008584	biological_process	male gonad development
E	0016209	molecular_function	antioxidant activity
E	0016491	molecular_function	oxidoreductase activity
E	0018401	biological_process	peptidyl-proline hydroxylation to 4-hydroxy-L-proline
E	0030198	biological_process	extracellular matrix organization
E	0042744	biological_process	hydrogen peroxide catabolic process
E	0042802	molecular_function	identical protein binding
E	0045454	biological_process	cell redox homeostasis
E	0051604	biological_process	protein maturation
E	0051920	molecular_function	peroxiredoxin activity
E	0060090	molecular_function	molecular adaptor activity
E	0072593	biological_process	reactive oxygen species metabolic process
E	0098869	biological_process	cellular oxidant detoxification
E	0140313	molecular_function	molecular sequestering activity
E	0140824	molecular_function	thioredoxin-dependent peroxiredoxin activity
E	2000255	biological_process	negative regulation of male germ cell proliferation
F	0004601	molecular_function	peroxidase activity
F	0005515	molecular_function	protein binding
F	0005615	cellular_component	extracellular space
F	0005737	cellular_component	cytoplasm
F	0005739	cellular_component	mitochondrion
F	0005783	cellular_component	endoplasmic reticulum
F	0005790	cellular_component	smooth endoplasmic reticulum
F	0005829	cellular_component	cytosol
F	0006979	biological_process	response to oxidative stress
F	0007283	biological_process	spermatogenesis
F	0008379	molecular_function	thioredoxin peroxidase activity
F	0008584	biological_process	male gonad development
F	0016209	molecular_function	antioxidant activity
F	0016491	molecular_function	oxidoreductase activity
F	0018401	biological_process	peptidyl-proline hydroxylation to 4-hydroxy-L-proline
F	0030198	biological_process	extracellular matrix organization
F	0042744	biological_process	hydrogen peroxide catabolic process
F	0042802	molecular_function	identical protein binding
F	0045454	biological_process	cell redox homeostasis
F	0051604	biological_process	protein maturation
F	0051920	molecular_function	peroxiredoxin activity
F	0060090	molecular_function	molecular adaptor activity
F	0072593	biological_process	reactive oxygen species metabolic process
F	0098869	biological_process	cellular oxidant detoxification
F	0140313	molecular_function	molecular sequestering activity
F	0140824	molecular_function	thioredoxin-dependent peroxiredoxin activity
F	2000255	biological_process	negative regulation of male germ cell proliferation
G	0004601	molecular_function	peroxidase activity
G	0005515	molecular_function	protein binding
G	0005615	cellular_component	extracellular space
G	0005737	cellular_component	cytoplasm
G	0005739	cellular_component	mitochondrion
G	0005783	cellular_component	endoplasmic reticulum
G	0005790	cellular_component	smooth endoplasmic reticulum
G	0005829	cellular_component	cytosol
G	0006979	biological_process	response to oxidative stress
G	0007283	biological_process	spermatogenesis
G	0008379	molecular_function	thioredoxin peroxidase activity
G	0008584	biological_process	male gonad development
G	0016209	molecular_function	antioxidant activity
G	0016491	molecular_function	oxidoreductase activity
G	0018401	biological_process	peptidyl-proline hydroxylation to 4-hydroxy-L-proline
G	0030198	biological_process	extracellular matrix organization
G	0042744	biological_process	hydrogen peroxide catabolic process
G	0042802	molecular_function	identical protein binding
G	0045454	biological_process	cell redox homeostasis
G	0051604	biological_process	protein maturation
G	0051920	molecular_function	peroxiredoxin activity
G	0060090	molecular_function	molecular adaptor activity
G	0072593	biological_process	reactive oxygen species metabolic process
G	0098869	biological_process	cellular oxidant detoxification
G	0140313	molecular_function	molecular sequestering activity
G	0140824	molecular_function	thioredoxin-dependent peroxiredoxin activity
G	2000255	biological_process	negative regulation of male germ cell proliferation
H	0004601	molecular_function	peroxidase activity
H	0005515	molecular_function	protein binding
H	0005615	cellular_component	extracellular space
H	0005737	cellular_component	cytoplasm
H	0005739	cellular_component	mitochondrion
H	0005783	cellular_component	endoplasmic reticulum
H	0005790	cellular_component	smooth endoplasmic reticulum
H	0005829	cellular_component	cytosol
H	0006979	biological_process	response to oxidative stress
H	0007283	biological_process	spermatogenesis
H	0008379	molecular_function	thioredoxin peroxidase activity
H	0008584	biological_process	male gonad development
H	0016209	molecular_function	antioxidant activity
H	0016491	molecular_function	oxidoreductase activity
H	0018401	biological_process	peptidyl-proline hydroxylation to 4-hydroxy-L-proline
H	0030198	biological_process	extracellular matrix organization
H	0042744	biological_process	hydrogen peroxide catabolic process
H	0042802	molecular_function	identical protein binding
H	0045454	biological_process	cell redox homeostasis
H	0051604	biological_process	protein maturation
H	0051920	molecular_function	peroxiredoxin activity
H	0060090	molecular_function	molecular adaptor activity
H	0072593	biological_process	reactive oxygen species metabolic process
H	0098869	biological_process	cellular oxidant detoxification
H	0140313	molecular_function	molecular sequestering activity
H	0140824	molecular_function	thioredoxin-dependent peroxiredoxin activity
H	2000255	biological_process	negative regulation of male germ cell proliferation
I	0004601	molecular_function	peroxidase activity
I	0005515	molecular_function	protein binding
I	0005615	cellular_component	extracellular space
I	0005737	cellular_component	cytoplasm
I	0005739	cellular_component	mitochondrion
I	0005783	cellular_component	endoplasmic reticulum
I	0005790	cellular_component	smooth endoplasmic reticulum
I	0005829	cellular_component	cytosol
I	0006979	biological_process	response to oxidative stress
I	0007283	biological_process	spermatogenesis
I	0008379	molecular_function	thioredoxin peroxidase activity
I	0008584	biological_process	male gonad development
I	0016209	molecular_function	antioxidant activity
I	0016491	molecular_function	oxidoreductase activity
I	0018401	biological_process	peptidyl-proline hydroxylation to 4-hydroxy-L-proline
I	0030198	biological_process	extracellular matrix organization
I	0042744	biological_process	hydrogen peroxide catabolic process
I	0042802	molecular_function	identical protein binding
I	0045454	biological_process	cell redox homeostasis
I	0051604	biological_process	protein maturation
I	0051920	molecular_function	peroxiredoxin activity
I	0060090	molecular_function	molecular adaptor activity
I	0072593	biological_process	reactive oxygen species metabolic process
I	0098869	biological_process	cellular oxidant detoxification
I	0140313	molecular_function	molecular sequestering activity
I	0140824	molecular_function	thioredoxin-dependent peroxiredoxin activity
I	2000255	biological_process	negative regulation of male germ cell proliferation
J	0004601	molecular_function	peroxidase activity
J	0005515	molecular_function	protein binding
J	0005615	cellular_component	extracellular space
J	0005737	cellular_component	cytoplasm
J	0005739	cellular_component	mitochondrion
J	0005783	cellular_component	endoplasmic reticulum
J	0005790	cellular_component	smooth endoplasmic reticulum
J	0005829	cellular_component	cytosol
J	0006979	biological_process	response to oxidative stress
J	0007283	biological_process	spermatogenesis
J	0008379	molecular_function	thioredoxin peroxidase activity
J	0008584	biological_process	male gonad development
J	0016209	molecular_function	antioxidant activity
J	0016491	molecular_function	oxidoreductase activity
J	0018401	biological_process	peptidyl-proline hydroxylation to 4-hydroxy-L-proline
J	0030198	biological_process	extracellular matrix organization
J	0042744	biological_process	hydrogen peroxide catabolic process
J	0042802	molecular_function	identical protein binding
J	0045454	biological_process	cell redox homeostasis
J	0051604	biological_process	protein maturation
J	0051920	molecular_function	peroxiredoxin activity
J	0060090	molecular_function	molecular adaptor activity
J	0072593	biological_process	reactive oxygen species metabolic process
J	0098869	biological_process	cellular oxidant detoxification
J	0140313	molecular_function	molecular sequestering activity
J	0140824	molecular_function	thioredoxin-dependent peroxiredoxin activity
J	2000255	biological_process	negative regulation of male germ cell proliferation

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1580
Details	Domain: {"description":"Thioredoxin","evidences":[{"source":"PROSITE-ProRule","id":"PRU00691","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	10
Details	Active site: {"description":"Cysteine sulfenic acid (-SOH) intermediate","evidences":[{"source":"UniProtKB","id":"Q13162","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---