3VW9
Human Glyoxalase I with an N-hydroxypyridone inhibitor
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0004462 | molecular_function | lactoylglutathione lyase activity |
A | 0005515 | molecular_function | protein binding |
A | 0005654 | cellular_component | nucleoplasm |
A | 0005737 | cellular_component | cytoplasm |
A | 0005829 | cellular_component | cytosol |
A | 0005886 | cellular_component | plasma membrane |
A | 0005975 | biological_process | carbohydrate metabolic process |
A | 0006357 | biological_process | regulation of transcription by RNA polymerase II |
A | 0006749 | biological_process | glutathione metabolic process |
A | 0008270 | molecular_function | zinc ion binding |
A | 0009438 | biological_process | methylglyoxal metabolic process |
A | 0016829 | molecular_function | lyase activity |
A | 0030316 | biological_process | osteoclast differentiation |
A | 0043066 | biological_process | negative regulation of apoptotic process |
A | 0046872 | molecular_function | metal ion binding |
A | 0070062 | cellular_component | extracellular exosome |
B | 0004462 | molecular_function | lactoylglutathione lyase activity |
B | 0005515 | molecular_function | protein binding |
B | 0005654 | cellular_component | nucleoplasm |
B | 0005737 | cellular_component | cytoplasm |
B | 0005829 | cellular_component | cytosol |
B | 0005886 | cellular_component | plasma membrane |
B | 0005975 | biological_process | carbohydrate metabolic process |
B | 0006357 | biological_process | regulation of transcription by RNA polymerase II |
B | 0006749 | biological_process | glutathione metabolic process |
B | 0008270 | molecular_function | zinc ion binding |
B | 0009438 | biological_process | methylglyoxal metabolic process |
B | 0016829 | molecular_function | lyase activity |
B | 0030316 | biological_process | osteoclast differentiation |
B | 0043066 | biological_process | negative regulation of apoptotic process |
B | 0046872 | molecular_function | metal ion binding |
B | 0070062 | cellular_component | extracellular exosome |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE ZN A 201 |
Chain | Residue |
A | GLN33 |
A | GLU99 |
B | HIS126 |
B | GLU172 |
B | HPJ202 |
site_id | AC2 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE EPE A 202 |
Chain | Residue |
A | HOH454 |
A | HOH465 |
A | SER20 |
A | ASP21 |
A | ASP153 |
A | LYS178 |
site_id | AC3 |
Number of Residues | 13 |
Details | BINDING SITE FOR RESIDUE HPJ A 203 |
Chain | Residue |
A | HIS126 |
A | MET157 |
A | PHE162 |
A | GLU172 |
A | MET179 |
A | MET183 |
A | HOH336 |
B | GLN33 |
B | CYS60 |
B | MET65 |
B | LEU69 |
B | GLU99 |
B | ZN201 |
site_id | AC4 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE ZN B 201 |
Chain | Residue |
A | HIS126 |
A | GLU172 |
A | HPJ203 |
B | GLN33 |
B | GLU99 |
site_id | AC5 |
Number of Residues | 14 |
Details | BINDING SITE FOR RESIDUE HPJ B 202 |
Chain | Residue |
A | GLN33 |
A | CYS60 |
A | LEU92 |
A | GLU99 |
A | ZN201 |
B | SER17 |
B | HIS126 |
B | MET157 |
B | PHE162 |
B | GLU172 |
B | MET179 |
B | ALA180 |
B | HOH1066 |
B | HOH1182 |
Functional Information from PROSITE/UniProt
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 2 |
Details | ACT_SITE: Proton donor/acceptor => ECO:0000269|PubMed:10521255, ECO:0000269|PubMed:9705294 |
Chain | Residue | Details |
A | GLU172 | |
B | GLU172 |
site_id | SWS_FT_FI2 |
Number of Residues | 4 |
Details | BINDING: BINDING => ECO:0000269|PubMed:23122816, ECO:0000269|PubMed:9218781, ECO:0000269|PubMed:9705294 |
Chain | Residue | Details |
A | GLN33 | |
A | GLU99 | |
B | GLN33 | |
B | GLU99 |
site_id | SWS_FT_FI3 |
Number of Residues | 4 |
Details | BINDING: |
Chain | Residue | Details |
A | ARG37 | |
A | ASN103 | |
B | ARG37 | |
B | ASN103 |
site_id | SWS_FT_FI4 |
Number of Residues | 4 |
Details | BINDING: in other chain |
Chain | Residue | Details |
A | ARG122 | |
A | LYS156 | |
B | ARG122 | |
B | LYS156 |
site_id | SWS_FT_FI5 |
Number of Residues | 4 |
Details | BINDING: in other chain => ECO:0000269|PubMed:23122816, ECO:0000269|PubMed:9218781, ECO:0000269|PubMed:9705294 |
Chain | Residue | Details |
A | HIS126 | |
A | GLU172 | |
B | HIS126 | |
B | GLU172 |
site_id | SWS_FT_FI6 |
Number of Residues | 2 |
Details | MOD_RES: N-acetylalanine => ECO:0000269|PubMed:20454679, ECO:0007744|PubMed:19413330, ECO:0007744|PubMed:25944712 |
Chain | Residue | Details |
A | ALA1 | |
B | ALA1 |
site_id | SWS_FT_FI7 |
Number of Residues | 2 |
Details | MOD_RES: N6-succinyllysine => ECO:0000250|UniProtKB:Q9CPU0 |
Chain | Residue | Details |
A | LYS87 | |
B | LYS87 |
site_id | SWS_FT_FI8 |
Number of Residues | 2 |
Details | MOD_RES: Phosphothreonine => ECO:0000269|PubMed:19199007 |
Chain | Residue | Details |
A | THR106 | |
B | THR106 |
site_id | SWS_FT_FI9 |
Number of Residues | 2 |
Details | MOD_RES: S-glutathionyl cysteine; alternate => ECO:0000269|PubMed:20454679 |
Chain | Residue | Details |
A | CYS138 | |
B | CYS138 |
site_id | SWS_FT_FI10 |
Number of Residues | 2 |
Details | MOD_RES: N6-succinyllysine; alternate => ECO:0000250|UniProtKB:Q9CPU0 |
Chain | Residue | Details |
A | LYS147 | |
B | LYS147 |
Catalytic Information from CSA
site_id | MCSA1 |
Number of Residues | 4 |
Details | M-CSA 32 |
Chain | Residue | Details |
A | GLN33 | metal ligand |
A | GLU99 | hydrogen bond acceptor, hydrogen bond donor, metal ligand, proton acceptor, proton donor |
A | HIS126 | metal ligand |
A | GLU172 | hydrogen bond acceptor, metal ligand, proton acceptor, proton donor, proton relay |
site_id | MCSA2 |
Number of Residues | 4 |
Details | M-CSA 32 |
Chain | Residue | Details |
B | GLN33 | metal ligand |
B | GLU99 | hydrogen bond acceptor, hydrogen bond donor, metal ligand, proton acceptor, proton donor |
B | HIS126 | metal ligand |
B | GLU172 | hydrogen bond acceptor, metal ligand, proton acceptor, proton donor, proton relay |