3VUZ

Crystal structure of histone methyltransferase SET7/9 in complex with AAM-1

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005694	cellular_component	chromosome
A	0006355	biological_process	regulation of DNA-templated transcription
A	0016279	molecular_function	protein-lysine N-methyltransferase activity
A	0140945	molecular_function	histone H3K4 monomethyltransferase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	19
Details	BINDING SITE FOR RESIDUE K15 A 401

Chain	Residue
A	GLY4
A	ASN282
A	HIS293
A	LYS294
A	ASN296
A	HIS297
A	TYR305
A	TYR335
A	TYR337
A	TRP352
A	HOH523
A	ILE223
A	SER225
A	ALA226
A	GLU228
A	TYR245
A	GLY264
A	ASN265
A	THR266

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	3
Details	BINDING: BINDING => ECO:0000269|PubMed:12514135, ECO:0000269|PubMed:12540855

Chain	Residue	Details
A	ALA226
A	ASN296
A	HIS297

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00190, ECO:0000269|PubMed:12514135, ECO:0000269|PubMed:12540855

Chain	Residue	Details
A	GLU356

---

site_id	SWS_FT_FI3
Number of Residues	5
Details	SITE: Histone H3K4 binding => ECO:0000269|PubMed:12540855

Chain	Residue	Details
A	TYR245
A	ASP256
A	THR266
A	LYS317
A	TYR335

---

Catalytic Information from CSA

site_id	MCSA1
Number of Residues	5
Details	M-CSA 350

Chain	Residue	Details
A	TYR245	activator, electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor
A	HIS293	electrostatic stabiliser, hydrogen bond acceptor
A	HIS297	electrostatic stabiliser, hydrogen bond acceptor
A	TYR305	activator, electrostatic stabiliser, hydrogen bond acceptor
A	TYR335	activator, electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor

---