3VRB
Mitochondrial rhodoquinol-fumarate reductase from the parasitic nematode Ascaris suum with the specific inhibitor flutolanil and substrate fumarate
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0005515 | molecular_function | protein binding |
| A | 0005739 | cellular_component | mitochondrion |
| A | 0005743 | cellular_component | mitochondrial inner membrane |
| A | 0006099 | biological_process | tricarboxylic acid cycle |
| A | 0006121 | biological_process | mitochondrial electron transport, succinate to ubiquinone |
| A | 0008177 | molecular_function | succinate dehydrogenase (quinone) activity |
| A | 0009055 | molecular_function | electron transfer activity |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0016627 | molecular_function | oxidoreductase activity, acting on the CH-CH group of donors |
| A | 0022900 | biological_process | electron transport chain |
| A | 0031966 | cellular_component | mitochondrial membrane |
| A | 0045273 | cellular_component | respiratory chain complex II (succinate dehydrogenase) |
| A | 0050660 | molecular_function | flavin adenine dinucleotide binding |
| B | 0005515 | molecular_function | protein binding |
| B | 0005739 | cellular_component | mitochondrion |
| B | 0005743 | cellular_component | mitochondrial inner membrane |
| B | 0006099 | biological_process | tricarboxylic acid cycle |
| B | 0006121 | biological_process | mitochondrial electron transport, succinate to ubiquinone |
| B | 0008177 | molecular_function | succinate dehydrogenase (quinone) activity |
| B | 0009055 | molecular_function | electron transfer activity |
| B | 0009060 | biological_process | aerobic respiration |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0022904 | biological_process | respiratory electron transport chain |
| B | 0031966 | cellular_component | mitochondrial membrane |
| B | 0045273 | cellular_component | respiratory chain complex II (succinate dehydrogenase) |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0051536 | molecular_function | iron-sulfur cluster binding |
| B | 0051537 | molecular_function | 2 iron, 2 sulfur cluster binding |
| B | 0051538 | molecular_function | 3 iron, 4 sulfur cluster binding |
| B | 0051539 | molecular_function | 4 iron, 4 sulfur cluster binding |
| C | 0005515 | molecular_function | protein binding |
| C | 0005739 | cellular_component | mitochondrion |
| C | 0005743 | cellular_component | mitochondrial inner membrane |
| C | 0006099 | biological_process | tricarboxylic acid cycle |
| C | 0006121 | biological_process | mitochondrial electron transport, succinate to ubiquinone |
| C | 0009055 | molecular_function | electron transfer activity |
| C | 0016020 | cellular_component | membrane |
| C | 0020037 | molecular_function | heme binding |
| C | 0031966 | cellular_component | mitochondrial membrane |
| C | 0045273 | cellular_component | respiratory chain complex II (succinate dehydrogenase) |
| C | 0046872 | molecular_function | metal ion binding |
| D | 0005515 | molecular_function | protein binding |
| D | 0005739 | cellular_component | mitochondrion |
| D | 0005740 | cellular_component | mitochondrial envelope |
| D | 0005743 | cellular_component | mitochondrial inner membrane |
| D | 0006099 | biological_process | tricarboxylic acid cycle |
| D | 0006121 | biological_process | mitochondrial electron transport, succinate to ubiquinone |
| D | 0016020 | cellular_component | membrane |
| D | 0020037 | molecular_function | heme binding |
| D | 0031966 | cellular_component | mitochondrial membrane |
| D | 0045273 | cellular_component | respiratory chain complex II (succinate dehydrogenase) |
| D | 0046872 | molecular_function | metal ion binding |
| D | 0048039 | molecular_function | ubiquinone binding |
| E | 0000166 | molecular_function | nucleotide binding |
| E | 0005515 | molecular_function | protein binding |
| E | 0005739 | cellular_component | mitochondrion |
| E | 0005743 | cellular_component | mitochondrial inner membrane |
| E | 0006099 | biological_process | tricarboxylic acid cycle |
| E | 0006121 | biological_process | mitochondrial electron transport, succinate to ubiquinone |
| E | 0008177 | molecular_function | succinate dehydrogenase (quinone) activity |
| E | 0009055 | molecular_function | electron transfer activity |
| E | 0016491 | molecular_function | oxidoreductase activity |
| E | 0016627 | molecular_function | oxidoreductase activity, acting on the CH-CH group of donors |
| E | 0022900 | biological_process | electron transport chain |
| E | 0031966 | cellular_component | mitochondrial membrane |
| E | 0045273 | cellular_component | respiratory chain complex II (succinate dehydrogenase) |
| E | 0050660 | molecular_function | flavin adenine dinucleotide binding |
| F | 0005515 | molecular_function | protein binding |
| F | 0005739 | cellular_component | mitochondrion |
| F | 0005743 | cellular_component | mitochondrial inner membrane |
| F | 0006099 | biological_process | tricarboxylic acid cycle |
| F | 0006121 | biological_process | mitochondrial electron transport, succinate to ubiquinone |
| F | 0008177 | molecular_function | succinate dehydrogenase (quinone) activity |
| F | 0009055 | molecular_function | electron transfer activity |
| F | 0009060 | biological_process | aerobic respiration |
| F | 0016491 | molecular_function | oxidoreductase activity |
| F | 0022904 | biological_process | respiratory electron transport chain |
| F | 0031966 | cellular_component | mitochondrial membrane |
| F | 0045273 | cellular_component | respiratory chain complex II (succinate dehydrogenase) |
| F | 0046872 | molecular_function | metal ion binding |
| F | 0051536 | molecular_function | iron-sulfur cluster binding |
| F | 0051537 | molecular_function | 2 iron, 2 sulfur cluster binding |
| F | 0051538 | molecular_function | 3 iron, 4 sulfur cluster binding |
| F | 0051539 | molecular_function | 4 iron, 4 sulfur cluster binding |
| G | 0005515 | molecular_function | protein binding |
| G | 0005739 | cellular_component | mitochondrion |
| G | 0005743 | cellular_component | mitochondrial inner membrane |
| G | 0006099 | biological_process | tricarboxylic acid cycle |
| G | 0006121 | biological_process | mitochondrial electron transport, succinate to ubiquinone |
| G | 0009055 | molecular_function | electron transfer activity |
| G | 0016020 | cellular_component | membrane |
| G | 0020037 | molecular_function | heme binding |
| G | 0031966 | cellular_component | mitochondrial membrane |
| G | 0045273 | cellular_component | respiratory chain complex II (succinate dehydrogenase) |
| G | 0046872 | molecular_function | metal ion binding |
| H | 0005515 | molecular_function | protein binding |
| H | 0005739 | cellular_component | mitochondrion |
| H | 0005740 | cellular_component | mitochondrial envelope |
| H | 0005743 | cellular_component | mitochondrial inner membrane |
| H | 0006099 | biological_process | tricarboxylic acid cycle |
| H | 0006121 | biological_process | mitochondrial electron transport, succinate to ubiquinone |
| H | 0016020 | cellular_component | membrane |
| H | 0020037 | molecular_function | heme binding |
| H | 0031966 | cellular_component | mitochondrial membrane |
| H | 0045273 | cellular_component | respiratory chain complex II (succinate dehydrogenase) |
| H | 0046872 | molecular_function | metal ion binding |
| H | 0048039 | molecular_function | ubiquinone binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE FUM A 701 |
| Chain | Residue |
| A | GLY85 |
| A | HIS276 |
| A | THR288 |
| A | GLU289 |
| A | ARG320 |
| A | HIS387 |
| A | ARG432 |
| A | ALA435 |
| A | FAD702 |
| site_id | AC2 |
| Number of Residues | 33 |
| Details | BINDING SITE FOR RESIDUE FAD A 702 |
| Chain | Residue |
| A | GLY48 |
| A | ALA49 |
| A | GLY50 |
| A | GLY51 |
| A | ALA52 |
| A | THR71 |
| A | LYS72 |
| A | MET73 |
| A | SER78 |
| A | HIS79 |
| A | THR80 |
| A | ALA83 |
| A | GLN84 |
| A | GLY85 |
| A | GLY86 |
| A | TYR199 |
| A | ALA201 |
| A | ALA235 |
| A | THR236 |
| A | GLY237 |
| A | THR247 |
| A | ASP255 |
| A | LEU286 |
| A | HIS387 |
| A | TYR388 |
| A | GLY420 |
| A | GLU421 |
| A | ARG432 |
| A | ALA435 |
| A | ASN436 |
| A | SER437 |
| A | LEU438 |
| A | FUM701 |
| site_id | AC3 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE FES B 301 |
| Chain | Residue |
| B | SER88 |
| B | CYS89 |
| B | ILE93 |
| B | CYS94 |
| B | GLY95 |
| B | CYS97 |
| B | CYS109 |
| site_id | AC4 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE SF4 B 302 |
| Chain | Residue |
| B | CYS182 |
| B | ILE183 |
| B | LEU184 |
| B | CYS185 |
| B | ALA186 |
| B | CYS187 |
| B | CYS188 |
| B | CYS249 |
| B | LEU253 |
| site_id | AC5 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE F3S B 303 |
| Chain | Residue |
| B | CYS192 |
| B | TYR202 |
| B | CYS239 |
| B | HIS240 |
| B | THR241 |
| B | ILE242 |
| B | MET243 |
| B | CYS245 |
| site_id | AC6 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE HEM C 201 |
| Chain | Residue |
| B | HIS240 |
| C | HIS75 |
| C | ARG76 |
| C | GLY79 |
| C | MET82 |
| C | HIS131 |
| C | THR132 |
| D | ARG63 |
| D | ALA66 |
| D | MET69 |
| D | VAL70 |
| D | HIS95 |
| site_id | AC7 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE FTN C 202 |
| Chain | Residue |
| B | PRO193 |
| B | SER194 |
| B | TRP197 |
| B | HIS240 |
| C | TRP69 |
| C | SER72 |
| C | ARG76 |
| D | ASP106 |
| D | TYR107 |
| site_id | AC8 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE EPH D 201 |
| Chain | Residue |
| C | MET82 |
| C | THR85 |
| C | PRO127 |
| C | LEU133 |
| C | VAL170 |
| D | ALA76 |
| D | TYR77 |
| D | HIS80 |
| D | PHE150 |
| D | GLU151 |
| D | TRP154 |
| site_id | AC9 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE FUM E 701 |
| Chain | Residue |
| E | GLY85 |
| E | PHE153 |
| E | HIS276 |
| E | THR288 |
| E | GLU289 |
| E | ARG320 |
| E | HIS387 |
| E | ARG432 |
| E | ALA435 |
| E | FAD702 |
| E | GLN84 |
| site_id | BC1 |
| Number of Residues | 32 |
| Details | BINDING SITE FOR RESIDUE FAD E 702 |
| Chain | Residue |
| E | ALA49 |
| E | GLY50 |
| E | GLY51 |
| E | ALA52 |
| E | THR71 |
| E | LYS72 |
| E | MET73 |
| E | SER78 |
| E | HIS79 |
| E | THR80 |
| E | ALA83 |
| E | GLN84 |
| E | GLY85 |
| E | GLY86 |
| E | TYR199 |
| E | PHE200 |
| E | ALA201 |
| E | ALA235 |
| E | THR236 |
| E | GLY237 |
| E | ASN252 |
| E | ASP255 |
| E | LEU286 |
| E | HIS387 |
| E | TYR388 |
| E | GLY420 |
| E | GLU421 |
| E | ARG432 |
| E | ALA435 |
| E | SER437 |
| E | LEU438 |
| E | FUM701 |
| site_id | BC2 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE FES F 301 |
| Chain | Residue |
| F | SER88 |
| F | CYS89 |
| F | GLY92 |
| F | ILE93 |
| F | CYS94 |
| F | GLY95 |
| F | CYS97 |
| F | CYS109 |
| site_id | BC3 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE SF4 F 302 |
| Chain | Residue |
| F | CYS182 |
| F | ILE183 |
| F | CYS185 |
| F | ALA186 |
| F | CYS187 |
| F | CYS188 |
| F | CYS249 |
| F | PRO250 |
| F | LEU253 |
| site_id | BC4 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE F3S F 303 |
| Chain | Residue |
| F | CYS192 |
| F | TYR202 |
| F | PRO205 |
| F | CYS239 |
| F | HIS240 |
| F | THR241 |
| F | ILE242 |
| F | MET243 |
| F | CYS245 |
| F | ILE259 |
| site_id | BC5 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE FTN F 304 |
| Chain | Residue |
| F | PRO193 |
| F | SER194 |
| F | TRP196 |
| F | TRP197 |
| F | HIS240 |
| G | TRP69 |
| G | SER72 |
| G | ARG76 |
| H | ASP106 |
| H | TYR107 |
| site_id | BC6 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE HEM G 201 |
| Chain | Residue |
| F | HIS240 |
| G | HIS75 |
| G | ARG76 |
| G | GLY79 |
| G | MET82 |
| G | HIS131 |
| G | THR132 |
| G | GLY135 |
| H | ARG63 |
| H | MET69 |
| H | HIS95 |
| H | VAL96 |
| H | GLY99 |
| site_id | BC7 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE EPH H 201 |
| Chain | Residue |
| G | MET82 |
| G | THR85 |
| G | ILE123 |
| G | PRO174 |
| H | ILE73 |
| H | ALA76 |
| H | TYR77 |
| H | HIS80 |
| H | PHE150 |
| H | TRP154 |
| H | GLU155 |
Functional Information from PROSITE/UniProt
| site_id | PS00197 |
| Number of Residues | 9 |
| Details | 2FE2S_FER_1 2Fe-2S ferredoxin-type iron-sulfur binding region signature. CREGICGSC |
| Chain | Residue | Details |
| B | CYS89-CYS97 |
| site_id | PS00198 |
| Number of Residues | 12 |
| Details | 4FE4S_FER_1 4Fe-4S ferredoxin-type iron-sulfur binding region signature. CiLCAcCSaSCP |
| Chain | Residue | Details |
| B | CYS182-PRO193 |
| site_id | PS00504 |
| Number of Residues | 10 |
| Details | FRD_SDH_FAD_BINDING Fumarate reductase / succinate dehydrogenase FAD-binding site. RSHTtaAqGG |
| Chain | Residue | Details |
| A | ARG77-GLY86 |
| site_id | PS01000 |
| Number of Residues | 25 |
| Details | SDH_CYT_1 Succinate dehydrogenase cytochrome b subunit signature 1. RPIaphLtiykpqMtwmvSglHRvT |
| Chain | Residue | Details |
| C | ARG54-THR78 |
| site_id | PS01001 |
| Number of Residues | 14 |
| Details | SDH_CYT_2 Succinate dehydrogenase cytochrome b subunit signature 2. HtlnGIRFIgFDmA |
| Chain | Residue | Details |
| C | HIS131-ALA144 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 94 |
| Details | TOPO_DOM: Mitochondrial matrix => ECO:0000305|PubMed:22577165 |
| Chain | Residue | Details |
| D | GLY26-PHE59 | |
| B | CYS245 | |
| B | CYS249 | |
| F | CYS89 | |
| F | CYS94 | |
| F | CYS97 | |
| F | CYS109 | |
| F | CYS182 | |
| F | CYS185 | |
| F | CYS188 | |
| F | CYS192 | |
| D | ASN105-ALA119 | |
| F | CYS239 | |
| F | CYS245 | |
| F | CYS249 | |
| H | GLY26-PHE59 | |
| H | ASN105-ALA119 | |
| B | CYS182 | |
| B | CYS185 | |
| B | CYS188 | |
| B | CYS192 | |
| B | CYS239 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 118 |
| Details | TRANSMEM: Helical => ECO:0000305|PubMed:22577165 |
| Chain | Residue | Details |
| D | LYS60-PHE78 | |
| E | THR71 | |
| E | SER78 | |
| E | THR80 | |
| E | GLY86 | |
| E | ALA201 | |
| E | SER437 | |
| E | LEU438 | |
| D | MET84-VAL104 | |
| D | ALA120-GLU141 | |
| H | LYS60-PHE78 | |
| H | MET84-VAL104 | |
| H | ALA120-GLU141 | |
| A | SER437 | |
| A | LEU438 | |
| E | ALA49 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 36 |
| Details | TOPO_DOM: Mitochondrial intermembrane => ECO:0000305|PubMed:22577165 |
| Chain | Residue | Details |
| D | ILE79-GLU83 | |
| D | HIS142-LEU156 | |
| H | ILE79-GLU83 | |
| H | HIS142-LEU156 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | BINDING: axial binding residue => ECO:0000269|PubMed:22577165, ECO:0000269|PubMed:26198225, ECO:0007744|PDB:3VR8, ECO:0007744|PDB:3VR9, ECO:0007744|PDB:3VRA, ECO:0007744|PDB:3VRB, ECO:0007744|PDB:4YSX, ECO:0007744|PDB:4YSY, ECO:0007744|PDB:4YSZ, ECO:0007744|PDB:4YT0, ECO:0007744|PDB:4YTM, ECO:0007744|PDB:4YTN, ECO:0007744|PDB:5C2T, ECO:0007744|PDB:5C3J |
| Chain | Residue | Details |
| D | HIS95 | |
| H | HIS95 | |
| G | SER72 | |
| G | ARG76 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:22577165, ECO:0007744|PDB:3VR8 |
| Chain | Residue | Details |
| D | TYR107 | |
| H | TYR107 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 10 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:22577165, ECO:0007744|PDB:3VR8, ECO:0007744|PDB:3VRB |
| Chain | Residue | Details |
| A | GLY85 | |
| E | ARG432 | |
| A | HIS276 | |
| A | THR288 | |
| A | GLU289 | |
| A | ARG432 | |
| E | GLY85 | |
| E | HIS276 | |
| E | THR288 | |
| E | GLU289 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:22577165, ECO:0000269|PubMed:26198225, ECO:0007744|PDB:3VR8, ECO:0007744|PDB:4YSX, ECO:0007744|PDB:4YSY, ECO:0007744|PDB:4YSZ, ECO:0007744|PDB:4YT0, ECO:0007744|PDB:4YTM, ECO:0007744|PDB:5C2T, ECO:0007744|PDB:5C3J |
| Chain | Residue | Details |
| A | ASP255 | |
| E | ASP255 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:22577165, ECO:0007744|PDB:3VRB |
| Chain | Residue | Details |
| A | HIS387 | |
| A | ALA435 | |
| E | HIS387 | |
| E | ALA435 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:22577165, ECO:0000269|PubMed:26198225, ECO:0007744|PDB:3VR8, ECO:0007744|PDB:3VR9, ECO:0007744|PDB:3VRA, ECO:0007744|PDB:3VRB, ECO:0007744|PDB:4YSX, ECO:0007744|PDB:4YSY, ECO:0007744|PDB:4YSZ, ECO:0007744|PDB:4YT0, ECO:0007744|PDB:4YTN, ECO:0007744|PDB:5C2T, ECO:0007744|PDB:5C3J |
| Chain | Residue | Details |
| A | GLU421 | |
| E | GLU421 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 2 |
| Details | MOD_RES: Tele-8alpha-FAD histidine => ECO:0000255|PIRSR:PIRSR611281-4, ECO:0000269|PubMed:22577165, ECO:0007744|PDB:3VR8, ECO:0007744|PDB:3VR9, ECO:0007744|PDB:3VRA, ECO:0007744|PDB:3VRB |
| Chain | Residue | Details |
| A | HIS79 | |
| E | HIS79 |
