3VQ2
Crystal structure of mouse TLR4/MD-2/LPS complex
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0002224 | biological_process | toll-like receptor signaling pathway |
| A | 0004888 | molecular_function | transmembrane signaling receptor activity |
| A | 0006955 | biological_process | immune response |
| A | 0016020 | cellular_component | membrane |
| B | 0002224 | biological_process | toll-like receptor signaling pathway |
| B | 0004888 | molecular_function | transmembrane signaling receptor activity |
| B | 0006955 | biological_process | immune response |
| B | 0016020 | cellular_component | membrane |
| C | 0001530 | molecular_function | lipopolysaccharide binding |
| C | 0035662 | molecular_function | Toll-like receptor 4 binding |
| C | 0045087 | biological_process | innate immune response |
| D | 0001530 | molecular_function | lipopolysaccharide binding |
| D | 0035662 | molecular_function | Toll-like receptor 4 binding |
| D | 0045087 | biological_process | innate immune response |
Functional Information from PROSITE/UniProt
| site_id | PS00159 |
| Number of Residues | 10 |
| Details | ALDOLASE_KDPG_KHG_1 KDPG and KHG aldolases active site. GIklhELTLR |
| Chain | Residue | Details |
| A | GLY224-ARG233 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:17803912, ECO:0007744|PDB:2Z64 |
| Chain | Residue | Details |
| C | ASN26 | |
| B | ASN34 | |
| B | ASN75 | |
| B | ASN172 | |
| B | ASN204 | |
| B | ASN237 | |
| B | ASN307 | |
| B | ASN492 | |
| B | ASN524 | |
| B | ASN572 | |
| D | ASN26 | |
| A | ASN172 | |
| A | ASN204 | |
| A | ASN237 | |
| A | ASN307 | |
| A | ASN492 | |
| A | ASN524 | |
| A | ASN572 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:17803912 |
| Chain | Residue | Details |
| C | ASN114 | |
| B | ASN622 | |
| C | ASN150 | |
| D | ASN114 | |
| D | ASN150 | |
| A | ASN622 | |
| B | ASN495 | |
| B | ASN575 | |
| B | ASN613 | |
| B | ASN621 |
