3VPC

ArgX from Sulfolobus tokodaii complexed with ADP

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0003824	molecular_function	catalytic activity
A	0005524	molecular_function	ATP binding
A	0005737	cellular_component	cytoplasm
A	0006526	biological_process	L-arginine biosynthetic process
A	0008652	biological_process	amino acid biosynthetic process
A	0009085	biological_process	lysine biosynthetic process
A	0016874	molecular_function	ligase activity
A	0016879	molecular_function	ligase activity, forming carbon-nitrogen bonds
A	0036211	biological_process	protein modification process
A	0042802	molecular_function	identical protein binding
A	0043774	molecular_function	coenzyme F420-2 alpha-glutamyl ligase activity
A	0046872	molecular_function	metal ion binding
B	0000166	molecular_function	nucleotide binding
B	0003824	molecular_function	catalytic activity
B	0005524	molecular_function	ATP binding
B	0005737	cellular_component	cytoplasm
B	0006526	biological_process	L-arginine biosynthetic process
B	0008652	biological_process	amino acid biosynthetic process
B	0009085	biological_process	lysine biosynthetic process
B	0016874	molecular_function	ligase activity
B	0016879	molecular_function	ligase activity, forming carbon-nitrogen bonds
B	0036211	biological_process	protein modification process
B	0042802	molecular_function	identical protein binding
B	0043774	molecular_function	coenzyme F420-2 alpha-glutamyl ligase activity
B	0046872	molecular_function	metal ion binding
C	0000166	molecular_function	nucleotide binding
C	0003824	molecular_function	catalytic activity
C	0005524	molecular_function	ATP binding
C	0005737	cellular_component	cytoplasm
C	0006526	biological_process	L-arginine biosynthetic process
C	0008652	biological_process	amino acid biosynthetic process
C	0009085	biological_process	lysine biosynthetic process
C	0016874	molecular_function	ligase activity
C	0016879	molecular_function	ligase activity, forming carbon-nitrogen bonds
C	0036211	biological_process	protein modification process
C	0042802	molecular_function	identical protein binding
C	0043774	molecular_function	coenzyme F420-2 alpha-glutamyl ligase activity
C	0046872	molecular_function	metal ion binding
D	0000166	molecular_function	nucleotide binding
D	0003824	molecular_function	catalytic activity
D	0005524	molecular_function	ATP binding
D	0005737	cellular_component	cytoplasm
D	0006526	biological_process	L-arginine biosynthetic process
D	0008652	biological_process	amino acid biosynthetic process
D	0009085	biological_process	lysine biosynthetic process
D	0016874	molecular_function	ligase activity
D	0016879	molecular_function	ligase activity, forming carbon-nitrogen bonds
D	0036211	biological_process	protein modification process
D	0042802	molecular_function	identical protein binding
D	0043774	molecular_function	coenzyme F420-2 alpha-glutamyl ligase activity
D	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	22
Details	BINDING SITE FOR RESIDUE ADP A 500

Chain	Residue
A	LYS87
A	TYR169
A	ILE170
A	ASP176
A	ARG200
A	ALA201
A	ASN202
A	ASN249
A	GLU250
A	HOH601
A	HOH624
A	ILE125
A	HOH714
A	HOH756
A	HOH823
A	LYS127
A	SER132
A	TRP133
A	GLY134
A	VAL137
A	GLN167
A	GLU168

---

site_id	AC2
Number of Residues	22
Details	BINDING SITE FOR RESIDUE ADP B 500

Chain	Residue
B	LYS87
B	ILE125
B	LYS127
B	SER132
B	TRP133
B	GLY134
B	VAL137
B	GLN167
B	GLU168
B	TYR169
B	ILE170
B	ASP176
B	ARG200
B	ALA201
B	ASN202
B	ASN249
B	GLU250
B	HOH620
B	HOH706
B	HOH725
B	HOH796
B	HOH810

---

site_id	AC3
Number of Residues	22
Details	BINDING SITE FOR RESIDUE ADP C 500

Chain	Residue
C	LYS87
C	ILE125
C	LYS127
C	GLY131
C	SER132
C	TRP133
C	GLY134
C	ARG135
C	VAL137
C	GLN167
C	GLU168
C	TYR169
C	ILE170
C	ASP176
C	ARG200
C	ALA201
C	ASN249
C	GLU250
C	HOH638
C	HOH659
C	HOH664
C	HOH705

---

site_id	AC4
Number of Residues	21
Details	BINDING SITE FOR RESIDUE ADP D 500

Chain	Residue
D	LYS87
D	ILE125
D	LYS127
D	SER132
D	TRP133
D	GLY134
D	VAL137
D	GLN167
D	GLU168
D	ILE170
D	ASP176
D	ARG200
D	ALA201
D	ASN202
D	ASN249
D	GLU250
D	HOH618
D	HOH667
D	HOH714
D	HOH760
D	HOH810

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	558
Details	Domain: {"description":"ATP-grasp","evidences":[{"source":"PROSITE-ProRule","id":"PRU00409","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	4
Details	Motif: {"description":"GF motif that is essential for ArgX substrate specificity","evidences":[{"source":"PubMed","id":"23434852","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	102
Details	Binding site: {"evidences":[{"source":"PubMed","id":"23434852","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	12
Details	Binding site: {"evidences":[{"source":"PubMed","id":"23434852","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---