3VIU

Crystal structure of PurL from thermus thermophilus

Replaces:  3AC6

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0000287	molecular_function	magnesium ion binding
A	0004642	molecular_function	phosphoribosylformylglycinamidine synthase activity
A	0005524	molecular_function	ATP binding
A	0005737	cellular_component	cytoplasm
A	0006164	biological_process	purine nucleotide biosynthetic process
A	0006189	biological_process	'de novo' IMP biosynthetic process
A	0016874	molecular_function	ligase activity
A	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	13
Details	BINDING SITE FOR RESIDUE ADP A 800

Chain	Residue
A	TYR44
A	ASN523
A	VAL524
A	HOH781
A	PEG920
A	GLY66
A	GLU67
A	LYS83
A	GLU85
A	ASP109
A	ASP485
A	SER521
A	GLY522

---

site_id	AC2
Number of Residues	7
Details	BINDING SITE FOR RESIDUE PO4 A 900

Chain	Residue
A	HIS41
A	SER86
A	HIS87
A	ASN88
A	HIS89
A	SER525
A	HOH789

---

site_id	AC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG A 910

Chain	Residue
A	ASP430
A	ASN472
A	ASP620
A	HOH952
A	HOH1019
A	HOH1020

---

site_id	AC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE PEG A 920

Chain	Residue
A	TYR44
A	ARG48
A	ADP800
A	HOH983
A	HOH1017

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	Active site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00420","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	Active site: {"description":"Proton acceptor","evidences":[{"source":"HAMAP-Rule","id":"MF_00420","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	6
Details	Binding site: {}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00420","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"PubMed","id":"22232163","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---