3VI7
Human hematopoietic prostaglandin D synthase inhibitor complex structures
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000287 | molecular_function | magnesium ion binding |
| A | 0004364 | molecular_function | glutathione transferase activity |
| A | 0004667 | molecular_function | prostaglandin-D synthase activity |
| A | 0005509 | molecular_function | calcium ion binding |
| A | 0005515 | molecular_function | protein binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0006693 | biological_process | prostaglandin metabolic process |
| A | 0006749 | biological_process | glutathione metabolic process |
| A | 0007165 | biological_process | signal transduction |
| A | 0007626 | biological_process | locomotory behavior |
| A | 0019371 | biological_process | cyclooxygenase pathway |
| A | 0042803 | molecular_function | protein homodimerization activity |
| B | 0000287 | molecular_function | magnesium ion binding |
| B | 0004364 | molecular_function | glutathione transferase activity |
| B | 0004667 | molecular_function | prostaglandin-D synthase activity |
| B | 0005509 | molecular_function | calcium ion binding |
| B | 0005515 | molecular_function | protein binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0006693 | biological_process | prostaglandin metabolic process |
| B | 0006749 | biological_process | glutathione metabolic process |
| B | 0007165 | biological_process | signal transduction |
| B | 0007626 | biological_process | locomotory behavior |
| B | 0019371 | biological_process | cyclooxygenase pathway |
| B | 0042803 | molecular_function | protein homodimerization activity |
| C | 0000287 | molecular_function | magnesium ion binding |
| C | 0004364 | molecular_function | glutathione transferase activity |
| C | 0004667 | molecular_function | prostaglandin-D synthase activity |
| C | 0005509 | molecular_function | calcium ion binding |
| C | 0005515 | molecular_function | protein binding |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0005829 | cellular_component | cytosol |
| C | 0006693 | biological_process | prostaglandin metabolic process |
| C | 0006749 | biological_process | glutathione metabolic process |
| C | 0007165 | biological_process | signal transduction |
| C | 0007626 | biological_process | locomotory behavior |
| C | 0019371 | biological_process | cyclooxygenase pathway |
| C | 0042803 | molecular_function | protein homodimerization activity |
| D | 0000287 | molecular_function | magnesium ion binding |
| D | 0004364 | molecular_function | glutathione transferase activity |
| D | 0004667 | molecular_function | prostaglandin-D synthase activity |
| D | 0005509 | molecular_function | calcium ion binding |
| D | 0005515 | molecular_function | protein binding |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0005829 | cellular_component | cytosol |
| D | 0006693 | biological_process | prostaglandin metabolic process |
| D | 0006749 | biological_process | glutathione metabolic process |
| D | 0007165 | biological_process | signal transduction |
| D | 0007626 | biological_process | locomotory behavior |
| D | 0019371 | biological_process | cyclooxygenase pathway |
| D | 0042803 | molecular_function | protein homodimerization activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE GSH A 200 |
| Chain | Residue |
| A | TYR8 |
| A | HOH207 |
| A | HOH662 |
| D | ASP697 |
| A | ARG14 |
| A | TRP39 |
| A | LYS50 |
| A | ILE51 |
| A | PRO52 |
| A | GLN63 |
| A | SER64 |
| A | CBD201 |
| site_id | AC2 |
| Number of Residues | 17 |
| Details | BINDING SITE FOR RESIDUE CBD A 201 |
| Chain | Residue |
| A | GLY13 |
| A | ARG14 |
| A | MET99 |
| A | TRP104 |
| A | ALA105 |
| A | GLU106 |
| A | LYS107 |
| A | TYR152 |
| A | CYS156 |
| A | LYS198 |
| A | LEU199 |
| A | GSH200 |
| A | HOH203 |
| A | HOH235 |
| A | HOH288 |
| A | HOH418 |
| A | HOH653 |
| site_id | AC3 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE GSH B 400 |
| Chain | Residue |
| B | HOH71 |
| B | TYR208 |
| B | ARG214 |
| B | TRP239 |
| B | LYS243 |
| B | LYS250 |
| B | ILE251 |
| B | PRO252 |
| B | GLN263 |
| B | SER264 |
| B | CBD401 |
| B | HOH422 |
| B | HOH448 |
| B | HOH850 |
| C | ASP497 |
| site_id | AC4 |
| Number of Residues | 19 |
| Details | BINDING SITE FOR RESIDUE CBD B 401 |
| Chain | Residue |
| B | HOH37 |
| B | PHE209 |
| B | GLY213 |
| B | ARG214 |
| B | ASP296 |
| B | MET299 |
| B | SER300 |
| B | TRP304 |
| B | ALA305 |
| B | GLU306 |
| B | LYS312 |
| B | TYR352 |
| B | CYS356 |
| B | LYS398 |
| B | LEU399 |
| B | GSH400 |
| B | HOH415 |
| B | HOH679 |
| B | HOH868 |
| site_id | AC5 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE GSH C 600 |
| Chain | Residue |
| B | ASP297 |
| C | HOH103 |
| C | HOH282 |
| C | HOH296 |
| C | HOH309 |
| C | TYR408 |
| C | ARG414 |
| C | TRP439 |
| C | LYS443 |
| C | LYS450 |
| C | ILE451 |
| C | PRO452 |
| C | GLN463 |
| C | SER464 |
| C | HOH758 |
| site_id | AC6 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA C 902 |
| Chain | Residue |
| B | HOH42 |
| B | HOH462 |
| B | HOH505 |
| C | HOH165 |
| C | HOH336 |
| C | ASP496 |
| site_id | AC7 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE GSH D 800 |
| Chain | Residue |
| A | ASP97 |
| D | HOH156 |
| D | TYR608 |
| D | ARG614 |
| D | TRP639 |
| D | LYS643 |
| D | GLY649 |
| D | LYS650 |
| D | ILE651 |
| D | PRO652 |
| D | GLN663 |
| D | SER664 |
| D | HOH832 |
| site_id | AC8 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CA D 901 |
| Chain | Residue |
| D | HOH255 |
| D | ASP696 |
| D | HOH835 |
| A | HOH239 |
| A | HOH302 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 308 |
| Details | Domain: {"description":"GST N-terminal"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 472 |
| Details | Domain: {"description":"GST C-terminal"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 24 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"12627223","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15113825","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16547010","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18341273","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19939518","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
