3VI2
Crystal Structure Analysis of Plasmodium falciparum OMP Decarboxylase in complex with inhibitor HMOA
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0004590 | molecular_function | orotidine-5'-phosphate decarboxylase activity |
A | 0006207 | biological_process | 'de novo' pyrimidine nucleobase biosynthetic process |
A | 0006221 | biological_process | pyrimidine nucleotide biosynthetic process |
A | 0016831 | molecular_function | carboxy-lyase activity |
A | 0044205 | biological_process | 'de novo' UMP biosynthetic process |
B | 0004590 | molecular_function | orotidine-5'-phosphate decarboxylase activity |
B | 0006207 | biological_process | 'de novo' pyrimidine nucleobase biosynthetic process |
B | 0006221 | biological_process | pyrimidine nucleotide biosynthetic process |
B | 0016831 | molecular_function | carboxy-lyase activity |
B | 0044205 | biological_process | 'de novo' UMP biosynthetic process |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 11 |
Details | BINDING SITE FOR RESIDUE HMZ A 500 |
Chain | Residue |
A | ASP23 |
A | HOH390 |
B | ILE142 |
A | LYS102 |
A | THR195 |
A | ILE266 |
A | ALA268 |
A | GLN269 |
A | ASN291 |
A | GLY293 |
A | ARG294 |
site_id | AC2 |
Number of Residues | 11 |
Details | BINDING SITE FOR RESIDUE HMZ B 600 |
Chain | Residue |
B | GLY21 |
B | ASP23 |
B | THR195 |
B | GLY265 |
B | ILE266 |
B | ALA268 |
B | GLN269 |
B | ASN291 |
B | GLY293 |
B | ARG294 |
B | HOH364 |
site_id | AC3 |
Number of Residues | 1 |
Details | BINDING SITE FOR RESIDUE NA B 324 |
Chain | Residue |
A | ASN15 |
Functional Information from PROSITE/UniProt
site_id | PS00156 |
Number of Residues | 14 |
Details | OMPDECASE Orotidine 5'-phosphate decarboxylase active site. TIlDmKinDIGnTV |
Chain | Residue | Details |
A | THR133-VAL146 |