3VH9

Crystal structure of Aeromonas proteolytica aminopeptidase complexed with 8-quinolinol

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0006508	biological_process	proteolysis
A	0008235	molecular_function	metalloexopeptidase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ZN A 301

Chain	Residue
A	ASP117
A	GLU152
A	HIS256
A	ZN302
A	HQY303

---

site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE ZN A 302

Chain	Residue
A	ZN301
A	HQY303
A	HIS97
A	ASP117
A	GLU152
A	ASP179

---

site_id	AC3
Number of Residues	14
Details	BINDING SITE FOR RESIDUE HQY A 303

Chain	Residue
A	HIS97
A	ASP117
A	GLU152
A	ASP179
A	GLY224
A	TYR225
A	CYS227
A	TYR251
A	ILE255
A	HIS256
A	ZN301
A	ZN302
A	HOH451
A	HOH508

---

site_id	AC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE NA A 304

Chain	Residue
A	THR194
A	THR197
A	HOH468
A	HOH600
A	HOH625

---

site_id	AC5
Number of Residues	7
Details	BINDING SITE FOR RESIDUE NA A 305

Chain	Residue
A	SER51
A	ASN74
A	NA312
A	HOH496
A	HOH498
A	HOH501
A	HOH623

---

site_id	AC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE NA A 306

Chain	Residue
A	TYR218
A	HOH441
A	HOH455
A	HOH471
A	HOH510
A	HOH620

---

site_id	AC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE NA A 307

Chain	Residue
A	ASN249
A	HOH357
A	HOH442
A	HOH515
A	HOH525
A	HOH561

---

site_id	AC8
Number of Residues	6
Details	BINDING SITE FOR RESIDUE NA A 308

Chain	Residue
A	THR268
A	SER270
A	HOH355
A	HOH567
A	HOH609
A	HOH627

---

site_id	AC9
Number of Residues	6
Details	BINDING SITE FOR RESIDUE NA A 309

Chain	Residue
A	THR11
A	HOH352
A	HOH353
A	HOH473
A	HOH473
A	HOH619

---

site_id	BC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE NA A 310

Chain	Residue
A	GLU152
A	HOH451
A	HOH479
A	HOH534
A	HOH535

---

site_id	BC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE NA A 311

Chain	Residue
A	HOH329
A	HOH333
A	HOH359
A	HOH378
A	HOH416
A	HOH579

---

site_id	BC3
Number of Residues	7
Details	BINDING SITE FOR RESIDUE NA A 312

Chain	Residue
A	ASN74
A	NA305
A	HOH501
A	HOH549
A	HOH565
A	HOH616
A	HOH691

---

site_id	BC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL A 313

Chain	Residue
A	LEU213
A	PRO214
A	SER215

---

site_id	BC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL A 314

Chain	Residue
A	ALA19
A	LYS273
A	HOH590

---

site_id	BC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CL A 315

Chain	Residue
A	THR257
A	THR258
A	THR258
A	GLN259

---

site_id	BC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CL A 316

Chain	Residue
A	THR38
A	TYR73
A	ASN74
A	HOH397
A	HOH549

---

site_id	BC8
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL A 317

Chain	Residue
A	GLY72
A	HOH466

---

site_id	BC9
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CL A 318

Chain	Residue
A	HOH516
A	GLN6
A	ALA8
A	THR9

---

site_id	CC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CL A 319

Chain	Residue
A	GLY24
A	SER27
A	SER28
A	ASN200
A	HOH493

---

site_id	CC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL A 320

Chain	Residue
A	LYS184
A	HOH366
A	HOH387

---

site_id	CC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL A 321

Chain	Residue
A	GLY219
A	PHE220
A	HOH345

---

site_id	CC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SCN A 322

Chain	Residue
A	THR194
A	SER199
A	THR202
A	GLN203
A	LEU262
A	HOH625

---

site_id	CC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SCN A 323

Chain	Residue
A	TRP13
A	GLN16
A	ASN135
A	HOH352
A	HOH539

---

site_id	CC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE GOL A 324

Chain	Residue
A	SER28
A	SER31
A	PHE32
A	HOH411

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	5
Details	Binding site: {"evidences":[{"source":"PubMed","id":"10413478","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"11401547","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8087555","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8647077","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1AMP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1CP6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1FT7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1IGB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1LOK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1RTQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1TXR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1XRY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2ANP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2DEA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2IQ6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2NYQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3B35","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3B3C","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3B3S","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3B3T","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3B3V","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3B3W","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3B7I","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3FH4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3VH9","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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Catalytic Information from CSA

site_id	MCSA1
Number of Residues	6
Details	M-CSA 167

Chain	Residue	Details
A	HIS97	metal ligand
A	ASP117	metal ligand
A	GLU151	hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor
A	GLU152	metal ligand
A	ASP179	metal ligand
A	HIS256	metal ligand

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