3VEK

Both Zn Fingers of GATA1 Bound to Palindromic DNA Recognition Site, P1 Crystal Form

Functional Information from GO Data

Chain	GOid	namespace	contents
C	0003700	molecular_function	DNA-binding transcription factor activity
C	0006355	biological_process	regulation of DNA-templated transcription
C	0006357	biological_process	regulation of transcription by RNA polymerase II
C	0008270	molecular_function	zinc ion binding
C	0043565	molecular_function	sequence-specific DNA binding
F	0003700	molecular_function	DNA-binding transcription factor activity
F	0006355	biological_process	regulation of DNA-templated transcription
F	0006357	biological_process	regulation of transcription by RNA polymerase II
F	0008270	molecular_function	zinc ion binding
F	0043565	molecular_function	sequence-specific DNA binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 101

Chain	Residue
A	DC5
A	DT6
C	HIS289
F	ASP300

---

site_id	AC2
Number of Residues	1
Details	BINDING SITE FOR RESIDUE ZN A 102

Chain	Residue
A	DG15

---

site_id	AC3
Number of Residues	1
Details	BINDING SITE FOR RESIDUE ZN B 101

Chain	Residue
B	DG38

---

site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN C 401

Chain	Residue
C	CYS228
C	CYS204
C	CYS207
C	CYS225

---

site_id	AC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN C 402

Chain	Residue
C	CYS258
C	CYS261
C	CYS279
C	CYS282

---

site_id	AC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE ZN C 403

Chain	Residue
C	ASP218
C	THR220
C	HIS222

---

site_id	AC7
Number of Residues	3
Details	BINDING SITE FOR RESIDUE ZN D 101

Chain	Residue
C	ASP300
D	DT6
F	HIS289

---

site_id	AC8
Number of Residues	1
Details	BINDING SITE FOR RESIDUE ZN D 102

Chain	Residue
D	DG15

---

site_id	AC9
Number of Residues	1
Details	BINDING SITE FOR RESIDUE ZN E 101

Chain	Residue
E	DG38

---

site_id	BC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN F 401

Chain	Residue
F	CYS204
F	CYS207
F	CYS225
F	CYS228

---

site_id	BC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN F 402

Chain	Residue
F	CYS258
F	CYS261
F	CYS279
F	CYS282

---

site_id	BC3
Number of Residues	2
Details	BINDING SITE FOR RESIDUE ZN F 403

Chain	Residue
C	GLU203
F	HIS232

---

site_id	BC4
Number of Residues	2
Details	BINDING SITE FOR RESIDUE ZN F 404

Chain	Residue
C	HIS232
F	GLU203

---

site_id	BC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE ZN F 405

Chain	Residue
F	ASP218
F	THR220
F	HIS222

---

Functional Information from PROSITE/UniProt

site_id	PS00344
Number of Residues	25
Details	GATA_ZN_FINGER_1 GATA-type zinc finger domain. CvNCgata..TplWRRdrt.Ghyl...CNAC

Chain	Residue	Details
C	CYS204-CYS228
C	CYS258-CYS282

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	48
Details	Zinc finger: {"description":"GATA-type 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00094","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	48
Details	Zinc finger: {"description":"GATA-type 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00094","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	38
Details	Region: {"description":"Required for interaction with ZFPM1","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	Modified residue: {"description":"N6-acetyllysine; by EP300","evidences":[{"source":"UniProtKB","id":"P15976","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"21536911","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"8206977","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---