3V8I

Crystal Structure of a Drosophila melanogaster Dopamine N-Acetyltransferase

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0016747	molecular_function	acyltransferase activity, transferring groups other than amino-acyl groups
B	0016747	molecular_function	acyltransferase activity, transferring groups other than amino-acyl groups

Functional Information from PDB Data

site_id	AC1
Number of Residues	11
Details	BINDING SITE FOR RESIDUE EPE A 301

Chain	Residue
A	LEU146
A	HOH528
B	ASP132
A	VAL148
A	ARG153
A	GLY154
A	ALA158
A	SER186
A	HOH404
A	HOH422
A	HOH438

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site_id	AC2
Number of Residues	13
Details	BINDING SITE FOR RESIDUE EPE B 301

Chain	Residue
A	ASP132
A	HOH403
B	VAL148
B	ARG153
B	GLY154
B	ILE157
B	ALA158
B	TYR185
B	HOH401
B	HOH402
B	HOH417
B	HOH576
B	HOH676

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	BINDING: BINDING => ECO:0000269|PubMed:22716280, ECO:0007744|PDB:3TE4

Chain	Residue	Details
A	CYS181
A	VAL189
B	CYS181
B	VAL189

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site_id	SWS_FT_FI2
Number of Residues	6
Details	SITE: Has a role in the catalytic activity => ECO:0000269|PubMed:25406072

Chain	Residue	Details
A	GLY82
A	ALA217
A	VAL221
B	GLY82
B	ALA217
B	VAL221

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site_id	SWS_FT_FI3
Number of Residues	2
Details	SITE: Might be involved in substrate binding => ECO:0000269|PubMed:25406072

Chain	Residue	Details
A	ASP99
B	ASP99

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site_id	SWS_FT_FI4
Number of Residues	2
Details	SITE: Regulates binding affinity for coenzyme A (CoASH) => ECO:0000269|PubMed:25406072

Chain	Residue	Details
A	ARG188
B	ARG188

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site_id	SWS_FT_FI5
Number of Residues	2
Details	SITE: Acetyl-CoA => ECO:0000269|PubMed:22716280, ECO:0007744|PDB:3TE4

Chain	Residue	Details
A	ALA227
B	ALA227

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