3V8G

Crystal structure of an asymmetric trimer of a glutamate transporter homologue (GltPh)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005283	molecular_function	amino acid:sodium symporter activity
A	0005886	cellular_component	plasma membrane
A	0006835	biological_process	dicarboxylic acid transport
A	0006865	biological_process	amino acid transport
A	0015108	molecular_function	chloride transmembrane transporter activity
A	0015183	molecular_function	L-aspartate transmembrane transporter activity
A	0015293	molecular_function	symporter activity
A	0015501	molecular_function	glutamate:sodium symporter activity
A	0016020	cellular_component	membrane
A	0035725	biological_process	sodium ion transmembrane transport
A	0042802	molecular_function	identical protein binding
A	0046872	molecular_function	metal ion binding
A	0070207	biological_process	protein homotrimerization
A	0070778	biological_process	L-aspartate transmembrane transport
A	0140009	biological_process	L-aspartate import across plasma membrane
A	1902476	biological_process	chloride transmembrane transport
B	0005283	molecular_function	amino acid:sodium symporter activity
B	0005886	cellular_component	plasma membrane
B	0006835	biological_process	dicarboxylic acid transport
B	0006865	biological_process	amino acid transport
B	0015108	molecular_function	chloride transmembrane transporter activity
B	0015183	molecular_function	L-aspartate transmembrane transporter activity
B	0015293	molecular_function	symporter activity
B	0015501	molecular_function	glutamate:sodium symporter activity
B	0016020	cellular_component	membrane
B	0035725	biological_process	sodium ion transmembrane transport
B	0042802	molecular_function	identical protein binding
B	0046872	molecular_function	metal ion binding
B	0070207	biological_process	protein homotrimerization
B	0070778	biological_process	L-aspartate transmembrane transport
B	0140009	biological_process	L-aspartate import across plasma membrane
B	1902476	biological_process	chloride transmembrane transport
C	0005283	molecular_function	amino acid:sodium symporter activity
C	0005886	cellular_component	plasma membrane
C	0006835	biological_process	dicarboxylic acid transport
C	0006865	biological_process	amino acid transport
C	0015108	molecular_function	chloride transmembrane transporter activity
C	0015183	molecular_function	L-aspartate transmembrane transporter activity
C	0015293	molecular_function	symporter activity
C	0015501	molecular_function	glutamate:sodium symporter activity
C	0016020	cellular_component	membrane
C	0035725	biological_process	sodium ion transmembrane transport
C	0042802	molecular_function	identical protein binding
C	0046872	molecular_function	metal ion binding
C	0070207	biological_process	protein homotrimerization
C	0070778	biological_process	L-aspartate transmembrane transport
C	0140009	biological_process	L-aspartate import across plasma membrane
C	1902476	biological_process	chloride transmembrane transport
D	0005283	molecular_function	amino acid:sodium symporter activity
D	0005886	cellular_component	plasma membrane
D	0006835	biological_process	dicarboxylic acid transport
D	0006865	biological_process	amino acid transport
D	0015108	molecular_function	chloride transmembrane transporter activity
D	0015183	molecular_function	L-aspartate transmembrane transporter activity
D	0015293	molecular_function	symporter activity
D	0015501	molecular_function	glutamate:sodium symporter activity
D	0016020	cellular_component	membrane
D	0035725	biological_process	sodium ion transmembrane transport
D	0042802	molecular_function	identical protein binding
D	0046872	molecular_function	metal ion binding
D	0070207	biological_process	protein homotrimerization
D	0070778	biological_process	L-aspartate transmembrane transport
D	0140009	biological_process	L-aspartate import across plasma membrane
D	1902476	biological_process	chloride transmembrane transport
E	0005283	molecular_function	amino acid:sodium symporter activity
E	0005886	cellular_component	plasma membrane
E	0006835	biological_process	dicarboxylic acid transport
E	0006865	biological_process	amino acid transport
E	0015108	molecular_function	chloride transmembrane transporter activity
E	0015183	molecular_function	L-aspartate transmembrane transporter activity
E	0015293	molecular_function	symporter activity
E	0015501	molecular_function	glutamate:sodium symporter activity
E	0016020	cellular_component	membrane
E	0035725	biological_process	sodium ion transmembrane transport
E	0042802	molecular_function	identical protein binding
E	0046872	molecular_function	metal ion binding
E	0070207	biological_process	protein homotrimerization
E	0070778	biological_process	L-aspartate transmembrane transport
E	0140009	biological_process	L-aspartate import across plasma membrane
E	1902476	biological_process	chloride transmembrane transport
F	0005283	molecular_function	amino acid:sodium symporter activity
F	0005886	cellular_component	plasma membrane
F	0006835	biological_process	dicarboxylic acid transport
F	0006865	biological_process	amino acid transport
F	0015108	molecular_function	chloride transmembrane transporter activity
F	0015183	molecular_function	L-aspartate transmembrane transporter activity
F	0015293	molecular_function	symporter activity
F	0015501	molecular_function	glutamate:sodium symporter activity
F	0016020	cellular_component	membrane
F	0035725	biological_process	sodium ion transmembrane transport
F	0042802	molecular_function	identical protein binding
F	0046872	molecular_function	metal ion binding
F	0070207	biological_process	protein homotrimerization
F	0070778	biological_process	L-aspartate transmembrane transport
F	0140009	biological_process	L-aspartate import across plasma membrane
F	1902476	biological_process	chloride transmembrane transport

Functional Information from PDB Data

site_id	AC1
Number of Residues	14
Details	BINDING SITE FOR RESIDUE ASP A 501

Chain	Residue
A	ARG276
A	GLY359
A	ASP394
A	ARG397
A	THR398
A	ASN401
A	SER277
A	SER278
A	MET311
A	THR314
A	THR352
A	GLY354
A	VAL355
A	PRO356

---

site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE NA A 502

Chain	Residue
A	GLY306
A	ILE309
A	ASN310
A	ASN401
A	ASP405

---

site_id	AC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE NA A 503

Chain	Residue
A	THR308
A	MET311
A	SER349
A	ILE350
A	GLY351
A	THR352

---

site_id	AC4
Number of Residues	14
Details	BINDING SITE FOR RESIDUE ASP B 501

Chain	Residue
B	ARG276
B	SER277
B	SER278
B	MET311
B	THR314
B	THR352
B	GLY354
B	VAL355
B	PRO356
B	GLY359
B	ASP394
B	ARG397
B	THR398
B	ASN401

---

site_id	AC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE NA B 502

Chain	Residue
B	GLY306
B	ILE309
B	ASN310
B	ASN401
B	ASP405

---

site_id	AC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE NA B 503

Chain	Residue
B	THR308
B	MET311
B	SER349
B	ILE350
B	GLY351
B	THR352

---

site_id	AC7
Number of Residues	13
Details	BINDING SITE FOR RESIDUE ASP C 501

Chain	Residue
C	ARG276
C	SER277
C	SER278
C	MET311
C	GLY354
C	VAL355
C	PRO356
C	ALA358
C	GLY359
C	ASP394
C	ARG397
C	THR398
C	ASN401

---

site_id	AC8
Number of Residues	3
Details	BINDING SITE FOR RESIDUE NA C 502

Chain	Residue
C	GLY306
C	ASN310
C	ASP405

---

site_id	AC9
Number of Residues	5
Details	BINDING SITE FOR RESIDUE NA C 503

Chain	Residue
C	THR308
C	ILE309
C	SER349
C	ILE350
C	THR352

---

site_id	BC1
Number of Residues	13
Details	BINDING SITE FOR RESIDUE ASP D 501

Chain	Residue
D	ARG276
D	SER277
D	SER278
D	THR314
D	THR352
D	GLY354
D	VAL355
D	PRO356
D	GLY359
D	ASP394
D	ARG397
D	THR398
D	ASN401

---

site_id	BC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE NA D 502

Chain	Residue
D	GLY306
D	ILE309
D	ASN310
D	ASN401
D	ASP405

---

site_id	BC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE NA D 503

Chain	Residue
D	THR308
D	MET311
D	SER349
D	ILE350
D	GLY351
D	THR352

---

site_id	BC4
Number of Residues	14
Details	BINDING SITE FOR RESIDUE ASP E 501

Chain	Residue
E	THR314
E	THR352
E	GLY354
E	VAL355
E	PRO356
E	GLY359
E	ASP394
E	ARG397
E	THR398
E	ASN401
E	ARG276
E	SER277
E	SER278
E	MET311

---

site_id	BC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE NA E 502

Chain	Residue
E	GLY306
E	ILE309
E	ASN310
E	ASN401
E	ASP405

---

site_id	BC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE NA E 503

Chain	Residue
E	THR308
E	MET311
E	SER349
E	ILE350
E	GLY351
E	THR352

---

site_id	BC7
Number of Residues	13
Details	BINDING SITE FOR RESIDUE ASP F 501

Chain	Residue
F	ARG276
F	SER277
F	SER278
F	MET311
F	GLY354
F	VAL355
F	PRO356
F	ALA358
F	GLY359
F	ASP394
F	ARG397
F	THR398
F	ASN401

---

site_id	BC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE NA F 502

Chain	Residue
F	GLY306
F	ASN310
F	ASN401
F	ASP405

---

site_id	BC9
Number of Residues	4
Details	BINDING SITE FOR RESIDUE NA F 503

Chain	Residue
F	THR308
F	SER349
F	ILE350
F	THR352

---

Functional Information from PROSITE/UniProt

site_id	PS00713
Number of Residues	16
Details	NA_DICARBOXYL_SYMP_1 Sodium:dicarboxylate symporter family signature 1. PfGDlFVrLLKMLVmP

Chain	Residue	Details
A	PRO45-PRO60

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	108
Details	Transmembrane: {"description":"Helical; Name=1","evidences":[{"source":"PubMed","id":"15483603","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	364
Details	Topological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"15483603","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	120
Details	Transmembrane: {"description":"Helical; Name=2","evidences":[{"source":"PubMed","id":"15483603","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	402
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"15483603","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	132
Details	Transmembrane: {"description":"Helical; Name=3","evidences":[{"source":"PubMed","id":"15483603","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	76
Details	Transmembrane: {"description":"Discontinuously helical; Name=4","evidences":[{"source":"PubMed","id":"15483603","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	126
Details	Transmembrane: {"description":"Helical; Name=5","evidences":[{"source":"PubMed","id":"15483603","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	120
Details	Transmembrane: {"description":"Helical; Name=6","evidences":[{"source":"PubMed","id":"15483603","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	372
Details	Intramembrane: {"description":"Discontinuously helical","evidences":[{"source":"PubMed","id":"15483603","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	132
Details	Transmembrane: {"description":"Discontinuously helical; Name=7","evidences":[{"source":"PubMed","id":"15483603","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	120
Details	Transmembrane: {"description":"Helical; Name=8","evidences":[{"source":"PubMed","id":"15483603","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI12
Number of Residues	30
Details	Binding site: {"evidences":[{"source":"PubMed","id":"17230192","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2NWL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2NWX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3KBC","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI13
Number of Residues	30
Details	Binding site: {"evidences":[{"source":"PubMed","id":"17230192","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"2NWX","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI14
Number of Residues	6
Details	Binding site: {"evidences":[{"source":"PubMed","id":"17230192","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"2NWX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4X2S","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---