3V6J

Replication of N2,3-Ethenoguanine by DNA Polymerases

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000287	molecular_function	magnesium ion binding
A	0003677	molecular_function	DNA binding
A	0003684	molecular_function	damaged DNA binding
A	0003887	molecular_function	DNA-directed DNA polymerase activity
A	0005737	cellular_component	cytoplasm
A	0006260	biological_process	DNA replication
A	0006261	biological_process	DNA-templated DNA replication
A	0006281	biological_process	DNA repair
A	0006974	biological_process	DNA damage response
A	0016740	molecular_function	transferase activity
A	0016779	molecular_function	nucleotidyltransferase activity
A	0034061	molecular_function	DNA polymerase activity
A	0042276	biological_process	error-prone translesion synthesis
A	0046872	molecular_function	metal ion binding
J	0000287	molecular_function	magnesium ion binding
J	0003677	molecular_function	DNA binding
J	0003684	molecular_function	damaged DNA binding
J	0003887	molecular_function	DNA-directed DNA polymerase activity
J	0005737	cellular_component	cytoplasm
J	0006260	biological_process	DNA replication
J	0006261	biological_process	DNA-templated DNA replication
J	0006281	biological_process	DNA repair
J	0006974	biological_process	DNA damage response
J	0016740	molecular_function	transferase activity
J	0016779	molecular_function	nucleotidyltransferase activity
J	0034061	molecular_function	DNA polymerase activity
J	0042276	biological_process	error-prone translesion synthesis
J	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	18
Details	BINDING SITE FOR RESIDUE DCP A 401

Chain	Residue
A	ASP7
A	ARG51
A	ASP105
A	LYS159
A	MG402
A	MG403
A	HOH522
A	HOH596
B	EFG5
P	DOC13
A	PHE8
A	ASP9
A	TYR10
A	PHE11
A	TYR12
A	ALA44
A	THR45
A	TYR48

---

site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG A 402

Chain	Residue
A	ASP7
A	ASP105
A	GLU106
A	DCP401
A	MG403
A	HOH559

---

site_id	AC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG A 403

Chain	Residue
A	ASP7
A	PHE8
A	ASP105
A	DCP401
A	MG402
A	HOH596

---

site_id	AC4
Number of Residues	23
Details	BINDING SITE FOR RESIDUE DCP J 401

Chain	Residue
J	ASP7
J	PHE8
J	TYR10
J	PHE11
J	TYR12
J	ALA44
J	THR45
J	TYR48
J	ARG51
J	ALA57
J	GLY58
J	ASP105
J	LYS159
J	MG402
J	MG403
J	HOH503
J	HOH508
J	HOH524
J	HOH525
J	HOH526
K	DOC13
K	MG101
M	EFG5

---

site_id	AC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG J 402

Chain	Residue
J	ASP7
J	ASP105
J	GLU106
J	DCP401
J	MG403

---

site_id	AC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG J 403

Chain	Residue
J	ASP7
J	PHE8
J	ASP105
J	DCP401
J	MG402

---

site_id	AC7
Number of Residues	1
Details	BINDING SITE FOR RESIDUE MG K 101

Chain	Residue
J	DCP401

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	368
Details	Domain: {"description":"UmuC"}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	Active site: {}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	Binding site: {}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	Site: {"description":"Substrate discrimination"}

Chain

Residue

Details

---