3V3K
Human caspase 9 in complex with bacterial effector protein
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004197 | molecular_function | cysteine-type endopeptidase activity |
| A | 0006508 | biological_process | proteolysis |
| A | 0008234 | molecular_function | cysteine-type peptidase activity |
| C | 0004197 | molecular_function | cysteine-type endopeptidase activity |
| C | 0006508 | biological_process | proteolysis |
| C | 0008234 | molecular_function | cysteine-type peptidase activity |
| E | 0004197 | molecular_function | cysteine-type endopeptidase activity |
| E | 0006508 | biological_process | proteolysis |
| E | 0008234 | molecular_function | cysteine-type peptidase activity |
| G | 0004197 | molecular_function | cysteine-type endopeptidase activity |
| G | 0006508 | biological_process | proteolysis |
| G | 0008234 | molecular_function | cysteine-type peptidase activity |
| I | 0004197 | molecular_function | cysteine-type endopeptidase activity |
| I | 0006508 | biological_process | proteolysis |
| I | 0008234 | molecular_function | cysteine-type peptidase activity |
| K | 0004197 | molecular_function | cysteine-type endopeptidase activity |
| K | 0006508 | biological_process | proteolysis |
| K | 0008234 | molecular_function | cysteine-type peptidase activity |
| M | 0004197 | molecular_function | cysteine-type endopeptidase activity |
| M | 0006508 | biological_process | proteolysis |
| M | 0008234 | molecular_function | cysteine-type peptidase activity |
| O | 0004197 | molecular_function | cysteine-type endopeptidase activity |
| O | 0006508 | biological_process | proteolysis |
| O | 0008234 | molecular_function | cysteine-type peptidase activity |
Functional Information from PROSITE/UniProt
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 16 |
| Details | Active site: {"evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 8 |
| Details | Modified residue: {"description":"Phosphotyrosine; by ABL1","evidences":[{"source":"PubMed","id":"15657060","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 8 |
| Details | Modified residue: {"description":"(Microbial infection) ADP-riboxanated arginine","evidences":[{"source":"PubMed","id":"35338844","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"35446120","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 24 |
| Details | Region: {"description":"Interaction with host caspases"} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | MCSA1 |
| Number of Residues | 4 |
| Details | M-CSA 816 |
| Chain | Residue | Details |
| A | ARG177 | electrostatic stabiliser |
| A | HIS237 | proton acceptor, proton donor |
| A | GLY238 | electrostatic stabiliser |
| A | CYS285 | nucleofuge, nucleophile, proton acceptor, proton donor |
| site_id | MCSA2 |
| Number of Residues | 4 |
| Details | M-CSA 816 |
| Chain | Residue | Details |
| C | ARG177 | electrostatic stabiliser |
| C | HIS237 | proton acceptor, proton donor |
| C | GLY238 | electrostatic stabiliser |
| C | CYS285 | nucleofuge, nucleophile, proton acceptor, proton donor |
| site_id | MCSA3 |
| Number of Residues | 4 |
| Details | M-CSA 816 |
| Chain | Residue | Details |
| E | ARG177 | electrostatic stabiliser |
| E | HIS237 | proton acceptor, proton donor |
| E | GLY238 | electrostatic stabiliser |
| E | CYS285 | nucleofuge, nucleophile, proton acceptor, proton donor |
| site_id | MCSA4 |
| Number of Residues | 4 |
| Details | M-CSA 816 |
| Chain | Residue | Details |
| G | ARG177 | electrostatic stabiliser |
| G | HIS237 | proton acceptor, proton donor |
| G | GLY238 | electrostatic stabiliser |
| G | CYS285 | nucleofuge, nucleophile, proton acceptor, proton donor |
| site_id | MCSA5 |
| Number of Residues | 4 |
| Details | M-CSA 816 |
| Chain | Residue | Details |
| I | ARG177 | electrostatic stabiliser |
| I | HIS237 | proton acceptor, proton donor |
| I | GLY238 | electrostatic stabiliser |
| I | CYS285 | nucleofuge, nucleophile, proton acceptor, proton donor |
| site_id | MCSA6 |
| Number of Residues | 4 |
| Details | M-CSA 816 |
| Chain | Residue | Details |
| K | ARG177 | electrostatic stabiliser |
| K | HIS237 | proton acceptor, proton donor |
| K | GLY238 | electrostatic stabiliser |
| K | CYS285 | nucleofuge, nucleophile, proton acceptor, proton donor |
| site_id | MCSA7 |
| Number of Residues | 4 |
| Details | M-CSA 816 |
| Chain | Residue | Details |
| M | ARG177 | electrostatic stabiliser |
| M | HIS237 | proton acceptor, proton donor |
| M | GLY238 | electrostatic stabiliser |
| M | CYS285 | nucleofuge, nucleophile, proton acceptor, proton donor |
| site_id | MCSA8 |
| Number of Residues | 4 |
| Details | M-CSA 816 |
| Chain | Residue | Details |
| O | ARG177 | electrostatic stabiliser |
| O | HIS237 | proton acceptor, proton donor |
| O | GLY238 | electrostatic stabiliser |
| O | CYS285 | nucleofuge, nucleophile, proton acceptor, proton donor |
