3V3K

Human caspase 9 in complex with bacterial effector protein

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004197	molecular_function	cysteine-type endopeptidase activity
A	0006508	biological_process	proteolysis
A	0008234	molecular_function	cysteine-type peptidase activity
C	0004197	molecular_function	cysteine-type endopeptidase activity
C	0006508	biological_process	proteolysis
C	0008234	molecular_function	cysteine-type peptidase activity
E	0004197	molecular_function	cysteine-type endopeptidase activity
E	0006508	biological_process	proteolysis
E	0008234	molecular_function	cysteine-type peptidase activity
G	0004197	molecular_function	cysteine-type endopeptidase activity
G	0006508	biological_process	proteolysis
G	0008234	molecular_function	cysteine-type peptidase activity
I	0004197	molecular_function	cysteine-type endopeptidase activity
I	0006508	biological_process	proteolysis
I	0008234	molecular_function	cysteine-type peptidase activity
K	0004197	molecular_function	cysteine-type endopeptidase activity
K	0006508	biological_process	proteolysis
K	0008234	molecular_function	cysteine-type peptidase activity
M	0004197	molecular_function	cysteine-type endopeptidase activity
M	0006508	biological_process	proteolysis
M	0008234	molecular_function	cysteine-type peptidase activity
O	0004197	molecular_function	cysteine-type endopeptidase activity
O	0006508	biological_process	proteolysis
O	0008234	molecular_function	cysteine-type peptidase activity

Functional Information from PROSITE/UniProt

site_id	PS01121
Number of Residues	15
Details	CASPASE_HIS Caspase family histidine active site. HgaldCcvVvILSHG

Chain	Residue	Details
A	HIS224-GLY238

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site_id	PS01122
Number of Residues	12
Details	CASPASE_CYS Caspase family cysteine active site. KPKLFFIQACGG

Chain	Residue	Details
A	LYS276-GLY287

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	16
Details	ACT_SITE: ACT_SITE => ECO:0000250

Chain	Residue	Details
A	HIS237
A	CYS285
C	HIS237
C	CYS285
E	HIS237
E	CYS285
G	HIS237
G	CYS285
I	HIS237
I	CYS285
K	HIS237
K	CYS285
M	HIS237
M	CYS285
O	HIS237
O	CYS285

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site_id	SWS_FT_FI2
Number of Residues	8
Details	MOD_RES: Phosphotyrosine; by ABL1 => ECO:0000269|PubMed:15657060

Chain	Residue	Details
A	TYR153
C	TYR153
E	TYR153
G	TYR153
I	TYR153
K	TYR153
M	TYR153
O	TYR153

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site_id	SWS_FT_FI3
Number of Residues	8
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648

Chain	Residue	Details
A	SER298
C	SER298
E	SER298
G	SER296
I	SER298
K	SER298
M	SER298
O	SER298

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site_id	SWS_FT_FI4
Number of Residues	8
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:20068231

Chain	Residue	Details
A	SER298
C	SER298
E	SER298
G	SER296
I	SER298
K	SER298
M	SER298
O	SER298

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site_id	SWS_FT_FI5
Number of Residues	8
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163

Chain	Residue	Details
A	SER298
C	SER298
E	SER298
G	SER296
I	SER298
K	SER298
M	SER298
O	SER298

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site_id	SWS_FT_FI6
Number of Residues	8
Details	MOD_RES: (Microbial infection) ADP-riboxanated arginine => ECO:0000269|PubMed:35338844, ECO:0000269|PubMed:35446120

Chain	Residue	Details
A	ARG341
C	ARG341
E	ARG341
G	ARG341
I	ARG341
K	ARG341
M	ARG341
O	ARG341

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Catalytic Information from CSA

site_id	MCSA1
Number of Residues	4
Details	M-CSA 816

Chain	Residue	Details
A	ARG177	electrostatic stabiliser
A	HIS237	proton acceptor, proton donor
A	GLY238	electrostatic stabiliser
A	CYS285	nucleofuge, nucleophile, proton acceptor, proton donor

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site_id	MCSA2
Number of Residues	4
Details	M-CSA 816

Chain	Residue	Details
C	ARG177	electrostatic stabiliser
C	HIS237	proton acceptor, proton donor
C	GLY238	electrostatic stabiliser
C	CYS285	nucleofuge, nucleophile, proton acceptor, proton donor

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site_id	MCSA3
Number of Residues	4
Details	M-CSA 816

Chain	Residue	Details
E	ARG177	electrostatic stabiliser
E	HIS237	proton acceptor, proton donor
E	GLY238	electrostatic stabiliser
E	CYS285	nucleofuge, nucleophile, proton acceptor, proton donor

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site_id	MCSA4
Number of Residues	4
Details	M-CSA 816

Chain	Residue	Details
G	ARG177	electrostatic stabiliser
G	HIS237	proton acceptor, proton donor
G	GLY238	electrostatic stabiliser
G	CYS285	nucleofuge, nucleophile, proton acceptor, proton donor

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site_id	MCSA5
Number of Residues	4
Details	M-CSA 816

Chain	Residue	Details
I	ARG177	electrostatic stabiliser
I	HIS237	proton acceptor, proton donor
I	GLY238	electrostatic stabiliser
I	CYS285	nucleofuge, nucleophile, proton acceptor, proton donor

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site_id	MCSA6
Number of Residues	4
Details	M-CSA 816

Chain	Residue	Details
K	ARG177	electrostatic stabiliser
K	HIS237	proton acceptor, proton donor
K	GLY238	electrostatic stabiliser
K	CYS285	nucleofuge, nucleophile, proton acceptor, proton donor

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site_id	MCSA7
Number of Residues	4
Details	M-CSA 816

Chain	Residue	Details
M	ARG177	electrostatic stabiliser
M	HIS237	proton acceptor, proton donor
M	GLY238	electrostatic stabiliser
M	CYS285	nucleofuge, nucleophile, proton acceptor, proton donor

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site_id	MCSA8
Number of Residues	4
Details	M-CSA 816

Chain	Residue	Details
O	ARG177	electrostatic stabiliser
O	HIS237	proton acceptor, proton donor
O	GLY238	electrostatic stabiliser
O	CYS285	nucleofuge, nucleophile, proton acceptor, proton donor

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