3V1R

Crystal structures of the reverse transcriptase-associated ribonuclease H domain of XMRV with inhibitor beta-thujaplicinol

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003676	molecular_function	nucleic acid binding
A	0004523	molecular_function	RNA-DNA hybrid ribonuclease activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 A 1

Chain	Residue
A	SER584
A	ARG585
A	TYR586
A	LYS640

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site_id	AC2
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 A 2

Chain	Residue
A	ARG534
A	ARG534

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site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 A 3

Chain	Residue
A	ARG650
A	PHE528
A	LEU529
A	ARG534

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site_id	AC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 A 4

Chain	Residue
A	TYR522
A	ARG601
A	ALA644

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site_id	AC5
Number of Residues	7
Details	BINDING SITE FOR RESIDUE MRD A 672

Chain	Residue
A	ARG560
A	ARG560
A	ARG609
A	ARG609
A	LYS612
A	ASN613
A	LYS614

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site_id	AC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MN A 673

Chain	Residue
A	ASP524
A	GLU562
A	ASP583
A	JTH675

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site_id	AC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MN A 674

Chain	Residue
A	ASP524
A	HIS638
A	ASP653
A	ARG657
A	JTH675

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site_id	AC8
Number of Residues	9
Details	BINDING SITE FOR RESIDUE JTH A 675

Chain	Residue
A	ASP524
A	GLU562
A	ASP583
A	HIS638
A	HIS638
A	ASP653
A	ARG657
A	MN673
A	MN674

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00408, ECO:0000269|PubMed:22366278

Chain	Residue	Details
A	ASP524
A	GLU562
A	ASP583
A	ASP653

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site_id	SWS_FT_FI2
Number of Residues	7
Details	BINDING: BINDING => ECO:0000250|UniProtKB:A1Z651

Chain	Residue	Details
A	SER527
A	LEU529
A	GLN530
A	SER557
A	GLN559
A	ARG585
A	ARG609

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site_id	SWS_FT_FI3
Number of Residues	1
Details	SITE: Cleavage; by viral protease p14 => ECO:0000250

Chain	Residue	Details
A	LEU671

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