3UQS
Crystal structures of murine norovirus RNA-dependent RNA polymerase
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003723 | molecular_function | RNA binding |
| A | 0003968 | molecular_function | RNA-directed RNA polymerase activity |
| A | 0004386 | molecular_function | helicase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0006351 | biological_process | DNA-templated transcription |
| A | 0039694 | biological_process | viral RNA genome replication |
| B | 0003723 | molecular_function | RNA binding |
| B | 0003968 | molecular_function | RNA-directed RNA polymerase activity |
| B | 0004386 | molecular_function | helicase activity |
| B | 0005524 | molecular_function | ATP binding |
| B | 0006351 | biological_process | DNA-templated transcription |
| B | 0039694 | biological_process | viral RNA genome replication |
| C | 0003723 | molecular_function | RNA binding |
| C | 0003968 | molecular_function | RNA-directed RNA polymerase activity |
| C | 0004386 | molecular_function | helicase activity |
| C | 0005524 | molecular_function | ATP binding |
| C | 0006351 | biological_process | DNA-templated transcription |
| C | 0039694 | biological_process | viral RNA genome replication |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE SO4 A 516 |
| Chain | Residue |
| A | GLY48 |
| A | SER49 |
| A | SER58 |
| A | LEU59 |
| A | HOH540 |
| A | HOH579 |
| A | HOH850 |
| A | HOH906 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 A 517 |
| Chain | Residue |
| A | ASN149 |
| A | HOH620 |
| C | HOH671 |
| A | HIS146 |
| site_id | AC3 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 A 518 |
| Chain | Residue |
| A | ASP407 |
| A | ARG408 |
| A | HIS450 |
| site_id | AC4 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 B 516 |
| Chain | Residue |
| A | HOH941 |
| B | GLN61 |
| B | ARG64 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 B 517 |
| Chain | Residue |
| B | LYS26 |
| B | HIS423 |
| B | GLN424 |
| B | HOH890 |
| C | MET153 |
| C | LYS155 |
| site_id | AC6 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE SO4 B 518 |
| Chain | Residue |
| A | PRO3 |
| B | GLY48 |
| B | SER49 |
| B | SER58 |
| B | LEU59 |
| B | HOH875 |
| B | HOH929 |
| site_id | AC7 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 B 519 |
| Chain | Residue |
| B | HIS146 |
| B | ASN149 |
| B | HOH764 |
| site_id | AC8 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 B 520 |
| Chain | Residue |
| B | ASP407 |
| B | ARG408 |
| B | HIS450 |
| B | HOH571 |
| site_id | AC9 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 C 516 |
| Chain | Residue |
| C | ASP407 |
| C | ARG408 |
| C | HIS450 |
| C | HOH560 |
| site_id | BC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 C 517 |
| Chain | Residue |
| C | GLY48 |
| C | SER49 |
| C | SER58 |
| C | LEU59 |
| C | HOH891 |
| C | HOH962 |
| site_id | BC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 C 518 |
| Chain | Residue |
| C | ARG182 |
| C | TYR243 |
| C | THR244 |
| C | ARG245 |
| C | HOH861 |
| site_id | BC3 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE SO4 C 519 |
| Chain | Residue |
| C | HIS146 |
| C | ASN149 |
| site_id | BC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 C 520 |
| Chain | Residue |
| C | ARG231 |
| C | ASN234 |
| C | PHE235 |
| C | GLU337 |
| C | ASP398 |
| C | GLY401 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 363 |
| Details | Domain: {"description":"RdRp catalytic","evidences":[{"source":"PROSITE-ProRule","id":"PRU00539","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 6 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"21471315","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22341781","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24622391","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 3 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"21471315","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 3 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"21471315","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24622391","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 3 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"22341781","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24622391","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
