3UNF

Mouse 20S immunoproteasome in complex with PR-957

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000502	cellular_component	proteasome complex
A	0000932	cellular_component	P-body
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0005839	cellular_component	proteasome core complex
A	0006511	biological_process	ubiquitin-dependent protein catabolic process
A	0009615	biological_process	response to virus
A	0019773	cellular_component	proteasome core complex, alpha-subunit complex
A	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
A	0051603	biological_process	proteolysis involved in protein catabolic process
B	0000502	cellular_component	proteasome complex
B	0000932	cellular_component	P-body
B	0005634	cellular_component	nucleus
B	0005654	cellular_component	nucleoplasm
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0005839	cellular_component	proteasome core complex
B	0006511	biological_process	ubiquitin-dependent protein catabolic process
B	0019773	cellular_component	proteasome core complex, alpha-subunit complex
B	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
B	0043231	cellular_component	intracellular membrane-bounded organelle
B	0051603	biological_process	proteolysis involved in protein catabolic process
C	0000502	cellular_component	proteasome complex
C	0005634	cellular_component	nucleus
C	0005654	cellular_component	nucleoplasm
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0005839	cellular_component	proteasome core complex
C	0006511	biological_process	ubiquitin-dependent protein catabolic process
C	0019773	cellular_component	proteasome core complex, alpha-subunit complex
C	0042802	molecular_function	identical protein binding
C	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
C	0051603	biological_process	proteolysis involved in protein catabolic process
D	0000502	cellular_component	proteasome complex
D	0005634	cellular_component	nucleus
D	0005654	cellular_component	nucleoplasm
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0005839	cellular_component	proteasome core complex
D	0006511	biological_process	ubiquitin-dependent protein catabolic process
D	0019773	cellular_component	proteasome core complex, alpha-subunit complex
D	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
D	0051603	biological_process	proteolysis involved in protein catabolic process
E	0000502	cellular_component	proteasome complex
E	0001530	molecular_function	lipopolysaccharide binding
E	0002376	biological_process	immune system process
E	0002862	biological_process	negative regulation of inflammatory response to antigenic stimulus
E	0005515	molecular_function	protein binding
E	0005634	cellular_component	nucleus
E	0005654	cellular_component	nucleoplasm
E	0005737	cellular_component	cytoplasm
E	0005813	cellular_component	centrosome
E	0005829	cellular_component	cytosol
E	0005839	cellular_component	proteasome core complex
E	0006511	biological_process	ubiquitin-dependent protein catabolic process
E	0019773	cellular_component	proteasome core complex, alpha-subunit complex
E	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
E	0051603	biological_process	proteolysis involved in protein catabolic process
F	0000502	cellular_component	proteasome complex
F	0005515	molecular_function	protein binding
F	0005634	cellular_component	nucleus
F	0005654	cellular_component	nucleoplasm
F	0005737	cellular_component	cytoplasm
F	0005829	cellular_component	cytosol
F	0005839	cellular_component	proteasome core complex
F	0006511	biological_process	ubiquitin-dependent protein catabolic process
F	0019773	cellular_component	proteasome core complex, alpha-subunit complex
F	0031625	molecular_function	ubiquitin protein ligase binding
F	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
F	0051603	biological_process	proteolysis involved in protein catabolic process
G	0000502	cellular_component	proteasome complex
G	0000932	cellular_component	P-body
G	0003723	molecular_function	RNA binding
G	0005515	molecular_function	protein binding
G	0005634	cellular_component	nucleus
G	0005654	cellular_component	nucleoplasm
G	0005737	cellular_component	cytoplasm
G	0005739	cellular_component	mitochondrion
G	0005829	cellular_component	cytosol
G	0005839	cellular_component	proteasome core complex
G	0005840	cellular_component	ribosome
G	0005929	cellular_component	cilium
G	0006511	biological_process	ubiquitin-dependent protein catabolic process
G	0007519	biological_process	skeletal muscle tissue development
G	0016363	cellular_component	nuclear matrix
G	0019773	cellular_component	proteasome core complex, alpha-subunit complex
G	0030016	cellular_component	myofibril
G	0030017	cellular_component	sarcomere
G	0043123	biological_process	positive regulation of canonical NF-kappaB signal transduction
G	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
G	0050727	biological_process	regulation of inflammatory response
G	0051059	molecular_function	NF-kappaB binding
G	0051603	biological_process	proteolysis involved in protein catabolic process
H	0004298	molecular_function	threonine-type endopeptidase activity
H	0005839	cellular_component	proteasome core complex
H	0051603	biological_process	proteolysis involved in protein catabolic process
I	0000502	cellular_component	proteasome complex
I	0004175	molecular_function	endopeptidase activity
I	0005634	cellular_component	nucleus
I	0005654	cellular_component	nucleoplasm
I	0005737	cellular_component	cytoplasm
I	0005829	cellular_component	cytosol
I	0005839	cellular_component	proteasome core complex
I	0019774	cellular_component	proteasome core complex, beta-subunit complex
I	0030163	biological_process	protein catabolic process
I	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
I	0051603	biological_process	proteolysis involved in protein catabolic process
J	0000502	cellular_component	proteasome complex
J	0005634	cellular_component	nucleus
J	0005654	cellular_component	nucleoplasm
J	0005737	cellular_component	cytoplasm
J	0005829	cellular_component	cytosol
J	0005839	cellular_component	proteasome core complex
J	0010498	biological_process	proteasomal protein catabolic process
J	0019774	cellular_component	proteasome core complex, beta-subunit complex
J	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
J	0051603	biological_process	proteolysis involved in protein catabolic process
K	0004298	molecular_function	threonine-type endopeptidase activity
K	0005839	cellular_component	proteasome core complex
K	0051603	biological_process	proteolysis involved in protein catabolic process
L	0005839	cellular_component	proteasome core complex
L	0051603	biological_process	proteolysis involved in protein catabolic process
M	0005839	cellular_component	proteasome core complex
M	0051603	biological_process	proteolysis involved in protein catabolic process
N	0000502	cellular_component	proteasome complex
N	0002376	biological_process	immune system process
N	0004175	molecular_function	endopeptidase activity
N	0004298	molecular_function	threonine-type endopeptidase activity
N	0005634	cellular_component	nucleus
N	0005654	cellular_component	nucleoplasm
N	0005737	cellular_component	cytoplasm
N	0005829	cellular_component	cytosol
N	0005839	cellular_component	proteasome core complex
N	0006508	biological_process	proteolysis
N	0008233	molecular_function	peptidase activity
N	0009617	biological_process	response to bacterium
N	0016787	molecular_function	hydrolase activity
N	0019774	cellular_component	proteasome core complex, beta-subunit complex
N	0019882	biological_process	antigen processing and presentation
N	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
N	0051603	biological_process	proteolysis involved in protein catabolic process
N	1990111	cellular_component	spermatoproteasome complex
O	0000502	cellular_component	proteasome complex
O	0000932	cellular_component	P-body
O	0005634	cellular_component	nucleus
O	0005654	cellular_component	nucleoplasm
O	0005737	cellular_component	cytoplasm
O	0005829	cellular_component	cytosol
O	0005839	cellular_component	proteasome core complex
O	0006511	biological_process	ubiquitin-dependent protein catabolic process
O	0009615	biological_process	response to virus
O	0019773	cellular_component	proteasome core complex, alpha-subunit complex
O	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
O	0051603	biological_process	proteolysis involved in protein catabolic process
P	0000502	cellular_component	proteasome complex
P	0000932	cellular_component	P-body
P	0005634	cellular_component	nucleus
P	0005654	cellular_component	nucleoplasm
P	0005737	cellular_component	cytoplasm
P	0005829	cellular_component	cytosol
P	0005839	cellular_component	proteasome core complex
P	0006511	biological_process	ubiquitin-dependent protein catabolic process
P	0019773	cellular_component	proteasome core complex, alpha-subunit complex
P	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
P	0043231	cellular_component	intracellular membrane-bounded organelle
P	0051603	biological_process	proteolysis involved in protein catabolic process
Q	0000502	cellular_component	proteasome complex
Q	0005634	cellular_component	nucleus
Q	0005654	cellular_component	nucleoplasm
Q	0005737	cellular_component	cytoplasm
Q	0005829	cellular_component	cytosol
Q	0005839	cellular_component	proteasome core complex
Q	0006511	biological_process	ubiquitin-dependent protein catabolic process
Q	0019773	cellular_component	proteasome core complex, alpha-subunit complex
Q	0042802	molecular_function	identical protein binding
Q	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
Q	0051603	biological_process	proteolysis involved in protein catabolic process
R	0000502	cellular_component	proteasome complex
R	0005634	cellular_component	nucleus
R	0005654	cellular_component	nucleoplasm
R	0005737	cellular_component	cytoplasm
R	0005829	cellular_component	cytosol
R	0005839	cellular_component	proteasome core complex
R	0006511	biological_process	ubiquitin-dependent protein catabolic process
R	0019773	cellular_component	proteasome core complex, alpha-subunit complex
R	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
R	0051603	biological_process	proteolysis involved in protein catabolic process
S	0000502	cellular_component	proteasome complex
S	0001530	molecular_function	lipopolysaccharide binding
S	0002376	biological_process	immune system process
S	0002862	biological_process	negative regulation of inflammatory response to antigenic stimulus
S	0005515	molecular_function	protein binding
S	0005634	cellular_component	nucleus
S	0005654	cellular_component	nucleoplasm
S	0005737	cellular_component	cytoplasm
S	0005813	cellular_component	centrosome
S	0005829	cellular_component	cytosol
S	0005839	cellular_component	proteasome core complex
S	0006511	biological_process	ubiquitin-dependent protein catabolic process
S	0019773	cellular_component	proteasome core complex, alpha-subunit complex
S	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
S	0051603	biological_process	proteolysis involved in protein catabolic process
T	0000502	cellular_component	proteasome complex
T	0005515	molecular_function	protein binding
T	0005634	cellular_component	nucleus
T	0005654	cellular_component	nucleoplasm
T	0005737	cellular_component	cytoplasm
T	0005829	cellular_component	cytosol
T	0005839	cellular_component	proteasome core complex
T	0006511	biological_process	ubiquitin-dependent protein catabolic process
T	0019773	cellular_component	proteasome core complex, alpha-subunit complex
T	0031625	molecular_function	ubiquitin protein ligase binding
T	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
T	0051603	biological_process	proteolysis involved in protein catabolic process
U	0000502	cellular_component	proteasome complex
U	0000932	cellular_component	P-body
U	0003723	molecular_function	RNA binding
U	0005515	molecular_function	protein binding
U	0005634	cellular_component	nucleus
U	0005654	cellular_component	nucleoplasm
U	0005737	cellular_component	cytoplasm
U	0005739	cellular_component	mitochondrion
U	0005829	cellular_component	cytosol
U	0005839	cellular_component	proteasome core complex
U	0005840	cellular_component	ribosome
U	0005929	cellular_component	cilium
U	0006511	biological_process	ubiquitin-dependent protein catabolic process
U	0007519	biological_process	skeletal muscle tissue development
U	0016363	cellular_component	nuclear matrix
U	0019773	cellular_component	proteasome core complex, alpha-subunit complex
U	0030016	cellular_component	myofibril
U	0030017	cellular_component	sarcomere
U	0043123	biological_process	positive regulation of canonical NF-kappaB signal transduction
U	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
U	0050727	biological_process	regulation of inflammatory response
U	0051059	molecular_function	NF-kappaB binding
U	0051603	biological_process	proteolysis involved in protein catabolic process
V	0004298	molecular_function	threonine-type endopeptidase activity
V	0005839	cellular_component	proteasome core complex
V	0051603	biological_process	proteolysis involved in protein catabolic process
W	0000502	cellular_component	proteasome complex
W	0004175	molecular_function	endopeptidase activity
W	0005634	cellular_component	nucleus
W	0005654	cellular_component	nucleoplasm
W	0005737	cellular_component	cytoplasm
W	0005829	cellular_component	cytosol
W	0005839	cellular_component	proteasome core complex
W	0019774	cellular_component	proteasome core complex, beta-subunit complex
W	0030163	biological_process	protein catabolic process
W	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
W	0051603	biological_process	proteolysis involved in protein catabolic process
X	0000502	cellular_component	proteasome complex
X	0005634	cellular_component	nucleus
X	0005654	cellular_component	nucleoplasm
X	0005737	cellular_component	cytoplasm
X	0005829	cellular_component	cytosol
X	0005839	cellular_component	proteasome core complex
X	0010498	biological_process	proteasomal protein catabolic process
X	0019774	cellular_component	proteasome core complex, beta-subunit complex
X	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
X	0051603	biological_process	proteolysis involved in protein catabolic process
Y	0004298	molecular_function	threonine-type endopeptidase activity
Y	0005839	cellular_component	proteasome core complex
Y	0051603	biological_process	proteolysis involved in protein catabolic process
Z	0005839	cellular_component	proteasome core complex
Z	0051603	biological_process	proteolysis involved in protein catabolic process
a	0005839	cellular_component	proteasome core complex
a	0051603	biological_process	proteolysis involved in protein catabolic process
b	0000502	cellular_component	proteasome complex
b	0002376	biological_process	immune system process
b	0004175	molecular_function	endopeptidase activity
b	0004298	molecular_function	threonine-type endopeptidase activity
b	0005634	cellular_component	nucleus
b	0005654	cellular_component	nucleoplasm
b	0005737	cellular_component	cytoplasm
b	0005829	cellular_component	cytosol
b	0005839	cellular_component	proteasome core complex
b	0006508	biological_process	proteolysis
b	0008233	molecular_function	peptidase activity
b	0009617	biological_process	response to bacterium
b	0016787	molecular_function	hydrolase activity
b	0019774	cellular_component	proteasome core complex, beta-subunit complex
b	0019882	biological_process	antigen processing and presentation
b	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
b	0051603	biological_process	proteolysis involved in protein catabolic process
b	1990111	cellular_component	spermatoproteasome complex

Functional Information from PDB Data

site_id	AC1
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CL A 301

Chain	Residue
A	ARG219

---

site_id	AC2
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CL A 302

Chain	Residue
A	SER6

---

site_id	AC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL D 301

Chain	Residue
D	THR153
E	LEU74
E	THR75

---

site_id	AC4
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL E 301

Chain	Residue
E	LYS27
E	GLY159

---

site_id	AC5
Number of Residues	2
Details	BINDING SITE FOR RESIDUE K G 301

Chain	Residue
A	HOH432
G	TYR159

---

site_id	AC6
Number of Residues	15
Details	BINDING SITE FOR RESIDUE 04C H 301

Chain	Residue
H	THR1
H	ARG19
H	ALA20
H	THR21
H	ASN22
H	LYS33
H	GLY45
H	GLY47
H	ALA49
H	THR52
H	SER129
H	GLY168
H	IOD302
H	HOH413
I	ASP124

---

site_id	AC7
Number of Residues	1
Details	BINDING SITE FOR RESIDUE IOD H 302

Chain	Residue
H	04C301

---

site_id	AC8
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL H 303

Chain	Residue
H	ILE82
H	THR86

---

site_id	AC9
Number of Residues	4
Details	BINDING SITE FOR RESIDUE K I 302

Chain	Residue
B	LEU98
I	GLN64
J	ASN82
J	ARG85

---

site_id	BC1
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CL J 301

Chain	Residue
J	ASN63

---

site_id	BC2
Number of Residues	12
Details	BINDING SITE FOR RESIDUE 04C K 301

Chain	Residue
K	THR1
K	ARG19
K	ALA20
K	THR21
K	MET31
K	LYS33
K	MET45
K	GLY47
K	ALA49
K	TYR169
K	IOD302
L	ASP125

---

site_id	BC3
Number of Residues	1
Details	BINDING SITE FOR RESIDUE IOD K 302

Chain	Residue
K	04C301

---

site_id	BC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE K K 303

Chain	Residue
K	ASN38
K	CYS63
K	TYR67

---

site_id	BC5
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CL L 301

Chain	Residue
L	ARG71

---

site_id	BC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE K L 303

Chain	Residue
L	ARG211
V	LYS29
V	GLY171
V	HOH403

---

site_id	BC7
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL M 301

Chain	Residue
L	ASP39
M	GLU133

---

site_id	BC8
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL M 302

Chain	Residue
M	ARG179
V	LEU122
b	ASN28

---

site_id	BC9
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CL M 303

Chain	Residue
M	THR109

---

site_id	CC1
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CL M 304

Chain	Residue
M	SER40

---

site_id	CC2
Number of Residues	15
Details	BINDING SITE FOR RESIDUE 04C N 201

Chain	Residue
H	SER118
N	THR1
N	ARG19
N	VAL20
N	SER21
N	ALA22
N	PHE31
N	LYS33
N	LEU45
N	GLY47
N	SER48
N	ALA49
N	SER168
N	IOD202
N	HOH305

---

site_id	CC3
Number of Residues	1
Details	BINDING SITE FOR RESIDUE IOD N 202

Chain	Residue
N	04C201

---

site_id	CC4
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CL N 203

Chain	Residue
N	PHE124

---

site_id	CC5
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CL O 302

Chain	Residue
O	ARG112

---

site_id	CC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CL P 301

Chain	Residue
O	SER151
O	HOH430
P	ILE78
P	THR79

---

site_id	CC7
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CL Q 302

Chain	Residue
Q	GLY161

---

site_id	CC8
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CL Q 303

Chain	Residue
Q	ARG116

---

site_id	CC9
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CL R 301

Chain	Residue
R	THR153

---

site_id	DC1
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CL R 302

Chain	Residue
R	ILE162

---

site_id	DC2
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL S 301

Chain	Residue
S	LYS27
S	GLY159

---

site_id	DC3
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CL S 302

Chain	Residue
S	GLU20

---

site_id	DC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE K S 303

Chain	Residue
R	ASN5
S	ASN5
S	ASP6
S	ARG122

---

site_id	DC5
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CL U 301

Chain	Residue
U	TYR158

---

site_id	DC6
Number of Residues	15
Details	BINDING SITE FOR RESIDUE 04C V 301

Chain	Residue
V	CYS31
V	GLY47
V	ALA49
V	THR52
V	SER129
V	GLY168
V	IOD302
V	HOH411
W	ASP124
W	ILE126
V	THR1
V	ARG19
V	ALA20
V	THR21
V	ASN22

---

site_id	DC7
Number of Residues	1
Details	BINDING SITE FOR RESIDUE IOD V 302

Chain	Residue
V	04C301

---

site_id	DC8
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CL V 303

Chain	Residue
V	THR80

---

site_id	DC9
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CL V 304

Chain	Residue
V	THR86

---

site_id	EC1
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL V 305

Chain	Residue
V	GLN91
b	ASP93

---

site_id	EC2
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CL V 306

Chain	Residue
V	HIS114

---

site_id	EC3
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CL W 301

Chain	Residue
W	ARG69

---

site_id	EC4
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CL X 301

Chain	Residue
X	ASN63

---

site_id	EC5
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL X 302

Chain	Residue
X	ASN63
X	TYR67

---

site_id	EC6
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CL X 303

Chain	Residue
X	K304

---

site_id	EC7
Number of Residues	1
Details	BINDING SITE FOR RESIDUE K X 304

Chain	Residue
X	CL303

---

site_id	EC8
Number of Residues	12
Details	BINDING SITE FOR RESIDUE 04C Y 301

Chain	Residue
Y	THR1
Y	ARG19
Y	ALA20
Y	THR21
Y	MET31
Y	MET45
Y	GLY47
Y	CYS48
Y	ALA49
Y	TYR169
Y	IOD302
Z	ASP125

---

site_id	EC9
Number of Residues	1
Details	BINDING SITE FOR RESIDUE IOD Y 302

Chain	Residue
Y	04C301

---

site_id	FC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL Z 301

Chain	Residue
L	LEU168
Z	THR167
Z	LEU168

---

site_id	FC2
Number of Residues	1
Details	BINDING SITE FOR RESIDUE K Z 303

Chain	Residue
Z	HOH433

---

site_id	FC3
Number of Residues	2
Details	BINDING SITE FOR RESIDUE K Z 304

Chain	Residue
Z	SER93
Z	HOH410

---

site_id	FC4
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL a 301

Chain	Residue
Z	ASP39
a	GLU133

---

site_id	FC5
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CL a 302

Chain	Residue
a	THR109

---

site_id	FC6
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CL a 304

Chain	Residue
b	ILE120

---

site_id	FC7
Number of Residues	1
Details	BINDING SITE FOR RESIDUE K a 305

Chain	Residue
a	TYR184

---

site_id	FC8
Number of Residues	13
Details	BINDING SITE FOR RESIDUE 04C b 201

Chain	Residue
b	THR1
b	ARG19
b	VAL20
b	SER21
b	PHE31
b	LYS33
b	LEU45
b	GLY47
b	SER48
b	ALA49
b	SER168
b	IOD202
b	HOH313

---

site_id	FC9
Number of Residues	2
Details	BINDING SITE FOR RESIDUE IOD b 202

Chain	Residue
b	SER129
b	04C201

---

site_id	GC1
Number of Residues	2
Details	BINDING SITE FOR RESIDUE K b 203

Chain	Residue
M	HOH423
b	ARG19

---

Functional Information from PROSITE/UniProt

site_id	PS00388
Number of Residues	23
Details	PROTEASOME_ALPHA_1 Proteasome alpha-type subunits signature. YdraiTvFSPdGHlfQVEYAqeA

Chain	Residue	Details
C	TYR2-ALA24
F	TYR7-ALA29
A	TYR5-ALA27
G	PHE8-ALA30
D	TYR0-ALA22
B	TYR4-ALA26
E	TYR3-ALA25

---

site_id	PS00854
Number of Residues	48
Details	PROTEASOME_BETA_1 Proteasome beta-type subunits signature. LAFkFqhGVIVAVDsratagsyisslrmn.KvieinpyllgtmsGcaAD

Chain	Residue	Details
K	LEU4-ASP51
b	MET4-ASP51
H	ALA4-ASP51
I	MET11-ASP58
J	ILE5-ASP52
a	LEU12-ASP59
L	LEU13-ASP60
B	LEU34-ASP81

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	ACT_SITE: Nucleophile => ECO:0000250

Chain	Residue	Details
N	THR1
b	THR1
L	SER134
Z	SER34
Z	SER40
Z	SER134

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	MOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:P28072

Chain	Residue	Details
N	SER35
b	SER35
D	SER55
R	SER8
R	SER48
R	SER55

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	MOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:P28065

Chain	Residue	Details
N	LYS33
N	LYS89
b	LYS33
b	LYS89
O	SER13
O	SER15

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	CARBOHYD: O-linked (GlcNAc) serine => ECO:0000269|PubMed:22556278

Chain	Residue	Details
L	SER30
L	SER181
Z	SER30
Z	SER181

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	CARBOHYD: O-linked (GlcNAc) serine => ECO:0000269|PubMed:22556278

Chain	Residue	Details
G	SER4
U	SER4
E	LYS205
S	LYS112
S	LYS205

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	MOD_RES: Phosphotyrosine => ECO:0007744|PubMed:18034455

Chain	Residue	Details
A	TYR75
O	TYR75

---

site_id	SWS_FT_FI7
Number of Residues	2
Details	MOD_RES: Phosphotyrosine => ECO:0000250|UniProtKB:P17220

Chain	Residue	Details
A	TYR120
O	TYR120

---

site_id	SWS_FT_FI8
Number of Residues	2
Details	MOD_RES: N6-acetyllysine => ECO:0007744|PubMed:23806337

Chain	Residue	Details
A	LYS170
O	LYS170

---