3UM7
Crystal structure of the human two pore domain K+ ion channel TRAAK (K2P4.1)
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005267 | molecular_function | potassium channel activity |
| A | 0016020 | cellular_component | membrane |
| A | 0071805 | biological_process | potassium ion transmembrane transport |
| B | 0005267 | molecular_function | potassium channel activity |
| B | 0016020 | cellular_component | membrane |
| B | 0071805 | biological_process | potassium ion transmembrane transport |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE K A 311 |
| Chain | Residue |
| A | GLY131 |
| A | TYR132 |
| A | GLY240 |
| A | PHE241 |
| A | K312 |
| B | GLY131 |
| B | TYR132 |
| B | GLY240 |
| B | PHE241 |
| site_id | AC2 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE K A 312 |
| Chain | Residue |
| A | ILE130 |
| A | GLY131 |
| A | VAL239 |
| A | GLY240 |
| A | K311 |
| A | K313 |
| B | ILE130 |
| B | GLY131 |
| B | VAL239 |
| B | GLY240 |
| site_id | AC3 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE K A 313 |
| Chain | Residue |
| A | THR129 |
| A | ILE130 |
| A | THR238 |
| A | VAL239 |
| A | K312 |
| B | THR129 |
| B | ILE130 |
| B | THR238 |
| B | VAL239 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE K A 314 |
| Chain | Residue |
| A | THR129 |
| A | THR238 |
| B | THR129 |
| B | THR238 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 46 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000269|PubMed:22282805, ECO:0000269|PubMed:23341632, ECO:0000269|PubMed:25471887, ECO:0000269|PubMed:25500157 |
| Chain | Residue | Details |
| A | MET27-SER29 | |
| A | GLY177-ALA198 | |
| B | MET27-SER29 | |
| B | GLY177-ALA198 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 198 |
| Details | TRANSMEM: Helical => ECO:0000269|PubMed:22282805, ECO:0000269|PubMed:23341632, ECO:0000269|PubMed:25471887, ECO:0000269|PubMed:25500157 |
| Chain | Residue | Details |
| A | THR30-PHE50 | |
| A | LEU144-ILE176 | |
| A | MET199-MET220 | |
| A | LEU260-VAL286 | |
| B | THR30-PHE50 | |
| B | LEU144-ILE176 | |
| B | MET199-MET220 | |
| B | LEU260-VAL286 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 172 |
| Details | TOPO_DOM: Extracellular => ECO:0000269|PubMed:22282805, ECO:0000269|PubMed:23341632, ECO:0000269|PubMed:25471887, ECO:0000269|PubMed:25500157 |
| Chain | Residue | Details |
| A | ARG51-ALA113 | |
| A | ALA136-ARG143 | |
| A | GLU221-LYS225 | |
| A | ALA246-PRO259 | |
| B | ARG51-ALA113 | |
| B | ALA136-ARG143 | |
| B | GLU221-LYS225 | |
| B | ALA246-PRO259 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 28 |
| Details | INTRAMEM: Helical; Name=Pore helix 1 => ECO:0000269|PubMed:22282805, ECO:0000269|PubMed:23341632, ECO:0000269|PubMed:25471887, ECO:0000269|PubMed:25500157 |
| Chain | Residue | Details |
| A | TRP114-THR128 | |
| B | TRP114-THR128 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 22 |
| Details | INTRAMEM: INTRAMEM => ECO:0000269|PubMed:22282805, ECO:0000269|PubMed:23341632, ECO:0000269|PubMed:25471887, ECO:0000269|PubMed:25500157 |
| Chain | Residue | Details |
| A | THR129-VAL135 | |
| A | GLY240-VAL245 | |
| B | THR129-VAL135 | |
| B | GLY240-VAL245 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 26 |
| Details | INTRAMEM: Helical; Name=Pore helix 2 => ECO:0000269|PubMed:22282805, ECO:0000269|PubMed:23341632, ECO:0000269|PubMed:25471887, ECO:0000269|PubMed:25500157 |
| Chain | Residue | Details |
| A | LEU226-VAL239 | |
| B | LEU226-VAL239 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:34390650, ECO:0007744|PDB:7LJ5 |
| Chain | Residue | Details |
| A | THR129 | |
| A | THR238 | |
| B | THR129 | |
| B | THR238 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:23341632, ECO:0000269|PubMed:25471887, ECO:0007744|PDB:4I9W, ECO:0007744|PDB:4WFE |
| Chain | Residue | Details |
| A | ILE130 | |
| A | VAL239 | |
| B | ILE130 | |
| B | VAL239 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 8 |
| Details | BINDING: BINDING => ECO:0000250|UniProtKB:P57789 |
| Chain | Residue | Details |
| A | GLY131 | |
| A | TYR132 | |
| A | GLY240 | |
| A | PHE241 | |
| B | GLY131 | |
| B | TYR132 | |
| B | GLY240 | |
| B | PHE241 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 4 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
| Chain | Residue | Details |
| A | GLN104 | |
| A | GLN108 | |
| B | GLN104 | |
| B | GLN108 |
