3ULA
Crystal structure of the TV3 mutant F63W-MD-2-Eritoran complex
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| B | 0001530 | molecular_function | lipopolysaccharide binding |
| B | 0001875 | molecular_function | lipopolysaccharide immune receptor activity |
| B | 0002221 | biological_process | pattern recognition receptor signaling pathway |
| B | 0002224 | biological_process | toll-like receptor signaling pathway |
| B | 0002376 | biological_process | immune system process |
| B | 0005515 | molecular_function | protein binding |
| B | 0005576 | cellular_component | extracellular region |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0006954 | biological_process | inflammatory response |
| B | 0006968 | biological_process | cellular defense response |
| B | 0007166 | biological_process | cell surface receptor signaling pathway |
| B | 0010008 | cellular_component | endosome membrane |
| B | 0015026 | molecular_function | coreceptor activity |
| B | 0031663 | biological_process | lipopolysaccharide-mediated signaling pathway |
| B | 0031666 | biological_process | positive regulation of lipopolysaccharide-mediated signaling pathway |
| B | 0032496 | biological_process | response to lipopolysaccharide |
| B | 0032497 | biological_process | detection of lipopolysaccharide |
| B | 0032760 | biological_process | positive regulation of tumor necrosis factor production |
| B | 0034142 | biological_process | toll-like receptor 4 signaling pathway |
| B | 0035662 | molecular_function | Toll-like receptor 4 binding |
| B | 0043235 | cellular_component | receptor complex |
| B | 0045087 | biological_process | innate immune response |
| B | 0046696 | cellular_component | lipopolysaccharide receptor complex |
| B | 0071222 | biological_process | cellular response to lipopolysaccharide |
| D | 0001530 | molecular_function | lipopolysaccharide binding |
| D | 0001875 | molecular_function | lipopolysaccharide immune receptor activity |
| D | 0002221 | biological_process | pattern recognition receptor signaling pathway |
| D | 0002224 | biological_process | toll-like receptor signaling pathway |
| D | 0002376 | biological_process | immune system process |
| D | 0005515 | molecular_function | protein binding |
| D | 0005576 | cellular_component | extracellular region |
| D | 0005886 | cellular_component | plasma membrane |
| D | 0006954 | biological_process | inflammatory response |
| D | 0006968 | biological_process | cellular defense response |
| D | 0007166 | biological_process | cell surface receptor signaling pathway |
| D | 0010008 | cellular_component | endosome membrane |
| D | 0015026 | molecular_function | coreceptor activity |
| D | 0031663 | biological_process | lipopolysaccharide-mediated signaling pathway |
| D | 0031666 | biological_process | positive regulation of lipopolysaccharide-mediated signaling pathway |
| D | 0032496 | biological_process | response to lipopolysaccharide |
| D | 0032497 | biological_process | detection of lipopolysaccharide |
| D | 0032760 | biological_process | positive regulation of tumor necrosis factor production |
| D | 0034142 | biological_process | toll-like receptor 4 signaling pathway |
| D | 0035662 | molecular_function | Toll-like receptor 4 binding |
| D | 0043235 | cellular_component | receptor complex |
| D | 0045087 | biological_process | innate immune response |
| D | 0046696 | cellular_component | lipopolysaccharide receptor complex |
| D | 0071222 | biological_process | cellular response to lipopolysaccharide |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 42 |
| Details | Repeat: {"description":"LRR 1"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 42 |
| Details | Repeat: {"description":"LRR 2"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 42 |
| Details | Repeat: {"description":"LRR 3"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 42 |
| Details | Repeat: {"description":"LRR 4"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 42 |
| Details | Repeat: {"description":"LRR 5"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 46 |
| Details | Repeat: {"description":"LRR 6"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 40 |
| Details | Repeat: {"description":"LRR 7"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 2 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"11706042","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17803912","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22363519","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 2 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"11706042","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17803912","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19252480","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22363519","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 2 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"11706042","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17803912","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19252480","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 8 |
| Details | Region: {"description":"Interaction with lipopolysaccharide","evidences":[{"source":"PubMed","id":"17569869","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17803912","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2E56","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2E59","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4G8A","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI12 |
| Number of Residues | 4 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"17569869","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2E56","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2E59","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
