3UEC
Crystal structure of human Survivin bound to histone H3 phosphorylated on threonine-3.
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000228 | cellular_component | nuclear chromosome |
| A | 0000278 | biological_process | mitotic cell cycle |
| A | 0000281 | biological_process | mitotic cytokinesis |
| A | 0000775 | cellular_component | chromosome, centromeric region |
| A | 0000776 | cellular_component | kinetochore |
| A | 0004869 | molecular_function | cysteine-type endopeptidase inhibitor activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005634 | cellular_component | nucleus |
| A | 0005654 | cellular_component | nucleoplasm |
| A | 0005694 | cellular_component | chromosome |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005819 | cellular_component | spindle |
| A | 0005829 | cellular_component | cytosol |
| A | 0005856 | cellular_component | cytoskeleton |
| A | 0005874 | cellular_component | microtubule |
| A | 0006468 | biological_process | protein phosphorylation |
| A | 0006915 | biological_process | apoptotic process |
| A | 0007059 | biological_process | chromosome segregation |
| A | 0007605 | biological_process | sensory perception of sound |
| A | 0008017 | molecular_function | microtubule binding |
| A | 0008284 | biological_process | positive regulation of cell population proliferation |
| A | 0015630 | cellular_component | microtubule cytoskeleton |
| A | 0019899 | molecular_function | enzyme binding |
| A | 0030496 | cellular_component | midbody |
| A | 0031267 | molecular_function | small GTPase binding |
| A | 0031503 | biological_process | protein-containing complex localization |
| A | 0032133 | cellular_component | chromosome passenger complex |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0042981 | biological_process | regulation of apoptotic process |
| A | 0043066 | biological_process | negative regulation of apoptotic process |
| A | 0045892 | biological_process | negative regulation of DNA-templated transcription |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0051087 | molecular_function | protein-folding chaperone binding |
| A | 0051256 | biological_process | mitotic spindle midzone assembly |
| A | 0051301 | biological_process | cell division |
| A | 0090267 | biological_process | positive regulation of mitotic cell cycle spindle assembly checkpoint |
| A | 0090307 | biological_process | mitotic spindle assembly |
| A | 1901970 | biological_process | positive regulation of mitotic sister chromatid separation |
| A | 1902425 | biological_process | positive regulation of attachment of mitotic spindle microtubules to kinetochore |
| A | 1903490 | biological_process | positive regulation of mitotic cytokinesis |
| A | 1990713 | cellular_component | survivin complex |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN A 143 |
| Chain | Residue |
| A | CYS57 |
| A | CYS60 |
| A | HIS77 |
| A | CYS84 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE EDO A 144 |
| Chain | Residue |
| A | ALA128 |
| A | ALA128 |
| A | VAL131 |
| A | ARG132 |
| A | ARG132 |
| site_id | AC3 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE PG4 A 145 |
| Chain | Residue |
| A | GLU94 |
| A | GLU95 |
| A | GLU95 |
| A | THR97 |
| A | GLY99 |
| A | HOH167 |
| A | HOH167 |
| site_id | AC4 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE 1PE A 146 |
| Chain | Residue |
| A | PHE13 |
| A | ARG18 |
| A | GLU40 |
| A | PHE86 |
| A | VAL89 |
| A | GLN92 |
| A | HOH169 |
| site_id | AC5 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE EDO A 147 |
| Chain | Residue |
| A | GLU107 |
| A | HOH162 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ACT A 148 |
| Chain | Residue |
| A | LEU14 |
| A | LYS15 |
| A | ASP16 |
| A | HOH185 |
| site_id | AC7 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE PEG A 149 |
| Chain | Residue |
| A | GLY30 |
| A | ASP70 |
| A | LYS120 |
| A | GLU123 |
| A | ALA139 |
| A | ASP142 |
| site_id | AC8 |
| Number of Residues | 18 |
| Details | BINDING SITE FOR CHAIN B OF N-TERMINAL FRAGMENT OF HISTONE H3 |
| Chain | Residue |
| A | GLU51 |
| A | LEU54 |
| A | LYS62 |
| A | GLU63 |
| A | LEU64 |
| A | GLU65 |
| A | GLY66 |
| A | TRP67 |
| A | ASP71 |
| A | GLU76 |
| A | HIS80 |
| B | HOH5 |
| B | HOH17 |
| B | HOH19 |
| B | HOH20 |
| B | HOH21 |
| B | HOH25 |
| B | HOH41 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:17956729, ECO:0007744|PDB:2QFA |
| Chain | Residue | Details |
| A | CYS57 | |
| A | CYS60 | |
| A | HIS77 | |
| A | CYS84 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | SITE: Interaction with FBXL7 => ECO:0000269|PubMed:25778398 |
| Chain | Residue | Details |
| A | GLU126 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine; by AURKC => ECO:0000269|PubMed:27332895 |
| Chain | Residue | Details |
| A | SER20 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 7 |
| Details | MOD_RES: N6-acetyllysine => ECO:0000269|PubMed:20826784 |
| Chain | Residue | Details |
| A | LYS23 | |
| A | LYS90 | |
| A | LYS110 | |
| A | LYS112 | |
| A | LYS115 | |
| A | LYS121 | |
| A | LYS129 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphothreonine; by CDK1 and CDK15 => ECO:0000269|PubMed:11069302, ECO:0000269|PubMed:24866247, ECO:0007744|PubMed:18691976 |
| Chain | Residue | Details |
| A | THR34 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphothreonine; by CK2; in vitro => ECO:0000269|PubMed:21252625 |
| Chain | Residue | Details |
| A | THR48 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphothreonine; by AURKB => ECO:0000269|PubMed:14610074 |
| Chain | Residue | Details |
| A | THR117 |
