3UEC

Crystal structure of human Survivin bound to histone H3 phosphorylated on threonine-3.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000228	cellular_component	nuclear chromosome
A	0000278	biological_process	mitotic cell cycle
A	0000281	biological_process	mitotic cytokinesis
A	0000775	cellular_component	chromosome, centromeric region
A	0000776	cellular_component	kinetochore
A	0004869	molecular_function	cysteine-type endopeptidase inhibitor activity
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005694	cellular_component	chromosome
A	0005737	cellular_component	cytoplasm
A	0005819	cellular_component	spindle
A	0005829	cellular_component	cytosol
A	0005874	cellular_component	microtubule
A	0006915	biological_process	apoptotic process
A	0007052	biological_process	mitotic spindle organization
A	0007059	biological_process	chromosome segregation
A	0007605	biological_process	sensory perception of sound
A	0008017	molecular_function	microtubule binding
A	0008284	biological_process	positive regulation of cell population proliferation
A	0015630	cellular_component	microtubule cytoskeleton
A	0019899	molecular_function	enzyme binding
A	0030414	molecular_function	peptidase inhibitor activity
A	0030496	cellular_component	midbody
A	0031267	molecular_function	small GTPase binding
A	0031503	biological_process	protein-containing complex localization
A	0032133	cellular_component	chromosome passenger complex
A	0042802	molecular_function	identical protein binding
A	0043066	biological_process	negative regulation of apoptotic process
A	0045171	cellular_component	intercellular bridge
A	0045892	biological_process	negative regulation of DNA-templated transcription
A	0046872	molecular_function	metal ion binding
A	0051087	molecular_function	protein-folding chaperone binding
A	0051233	cellular_component	spindle midzone
A	0051256	biological_process	mitotic spindle midzone assembly
A	0051301	biological_process	cell division
A	0090267	biological_process	positive regulation of mitotic cell cycle spindle assembly checkpoint
A	0090307	biological_process	mitotic spindle assembly
A	1901970	biological_process	positive regulation of mitotic sister chromatid separation
A	1902425	biological_process	positive regulation of attachment of mitotic spindle microtubules to kinetochore
A	1903490	biological_process	positive regulation of mitotic cytokinesis
A	1990713	cellular_component	survivin complex

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 143

Chain	Residue
A	CYS57
A	CYS60
A	HIS77
A	CYS84

---

site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE EDO A 144

Chain	Residue
A	ALA128
A	ALA128
A	VAL131
A	ARG132
A	ARG132

---

site_id	AC3
Number of Residues	7
Details	BINDING SITE FOR RESIDUE PG4 A 145

Chain	Residue
A	GLU94
A	GLU95
A	GLU95
A	THR97
A	GLY99
A	HOH167
A	HOH167

---

site_id	AC4
Number of Residues	7
Details	BINDING SITE FOR RESIDUE 1PE A 146

Chain	Residue
A	PHE13
A	ARG18
A	GLU40
A	PHE86
A	VAL89
A	GLN92
A	HOH169

---

site_id	AC5
Number of Residues	2
Details	BINDING SITE FOR RESIDUE EDO A 147

Chain	Residue
A	GLU107
A	HOH162

---

site_id	AC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ACT A 148

Chain	Residue
A	LEU14
A	LYS15
A	ASP16
A	HOH185

---

site_id	AC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE PEG A 149

Chain	Residue
A	GLY30
A	ASP70
A	LYS120
A	GLU123
A	ALA139
A	ASP142

---

site_id	AC8
Number of Residues	18
Details	BINDING SITE FOR CHAIN B OF N-TERMINAL FRAGMENT OF HISTONE H3

Chain	Residue
A	GLU51
A	LEU54
A	LYS62
A	GLU63
A	LEU64
A	GLU65
A	GLY66
A	TRP67
A	ASP71
A	GLU76
A	HIS80
B	HOH5
B	HOH17
B	HOH19
B	HOH20
B	HOH21
B	HOH25
B	HOH41

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	70
Details	Repeat: {"description":"BIR"}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"17956729","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2QFA","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	Site: {"description":"Interaction with FBXL7","evidences":[{"source":"PubMed","id":"25778398","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine; by AURKC","evidences":[{"source":"PubMed","id":"27332895","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	7
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"20826784","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	1
Details	Modified residue: {"description":"Phosphothreonine; by CDK1 and CDK15","evidences":[{"source":"PubMed","id":"11069302","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24866247","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18691976","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	1
Details	Modified residue: {"description":"Phosphothreonine; by CK2; in vitro","evidences":[{"source":"PubMed","id":"21252625","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	1
Details	Modified residue: {"description":"Phosphothreonine; by AURKB","evidences":[{"source":"PubMed","id":"14610074","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---