3UDL
3-heterocyclyl quinolone bound to HCV NS5B
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003723 | molecular_function | RNA binding |
| A | 0003968 | molecular_function | RNA-dependent RNA polymerase activity |
| A | 0039694 | biological_process | viral RNA genome replication |
| B | 0003723 | molecular_function | RNA binding |
| B | 0003968 | molecular_function | RNA-dependent RNA polymerase activity |
| B | 0039694 | biological_process | viral RNA genome replication |
| C | 0003723 | molecular_function | RNA binding |
| C | 0003968 | molecular_function | RNA-dependent RNA polymerase activity |
| C | 0039694 | biological_process | viral RNA genome replication |
| D | 0003723 | molecular_function | RNA binding |
| D | 0003968 | molecular_function | RNA-dependent RNA polymerase activity |
| D | 0039694 | biological_process | viral RNA genome replication |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE KLI A 571 |
| Chain | Residue |
| A | LEU419 |
| A | ALA486 |
| A | LEU489 |
| A | LEU497 |
| A | TRP528 |
| A | ARG422 |
| A | MET423 |
| A | HIS475 |
| A | SER476 |
| A | TYR477 |
| A | PRO479 |
| A | ILE482 |
| A | VAL485 |
| site_id | AC2 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE KLI B 571 |
| Chain | Residue |
| B | LEU419 |
| B | MET423 |
| B | HIS475 |
| B | SER476 |
| B | TYR477 |
| B | PRO479 |
| B | ILE482 |
| B | ASN483 |
| B | VAL485 |
| B | ALA486 |
| B | LEU489 |
| B | LEU497 |
| B | TRP528 |
| B | HOH728 |
| site_id | AC3 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE KLI C 571 |
| Chain | Residue |
| C | LEU419 |
| C | MET423 |
| C | HIS475 |
| C | SER476 |
| C | TYR477 |
| C | PRO479 |
| C | ILE482 |
| C | ASN483 |
| C | VAL485 |
| C | ALA486 |
| C | LEU489 |
| C | LEU497 |
| C | TRP528 |
| C | HOH667 |
| site_id | AC4 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE KLI D 571 |
| Chain | Residue |
| D | LEU419 |
| D | ARG422 |
| D | MET423 |
| D | HIS475 |
| D | SER476 |
| D | TYR477 |
| D | PRO479 |
| D | ILE482 |
| D | ASN483 |
| D | VAL485 |
| D | ALA486 |
| D | LEU489 |
| D | LEU497 |
| D | TRP528 |
| D | HOH706 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 12 |
| Details | BINDING: BINDING => ECO:0000305|PubMed:10557268, ECO:0000305|PubMed:11884572 |
| Chain | Residue | Details |
| A | ASP220 | |
| D | ASP220 | |
| D | ASP318 | |
| D | ASP319 | |
| A | ASP318 | |
| A | ASP319 | |
| B | ASP220 | |
| B | ASP318 | |
| B | ASP319 | |
| C | ASP220 | |
| C | ASP318 | |
| C | ASP319 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 8 |
| Details | MOD_RES: Phosphoserine; by host => ECO:0000250|UniProtKB:P26662 |
| Chain | Residue | Details |
| A | SER29 | |
| A | SER42 | |
| B | SER29 | |
| B | SER42 | |
| C | SER29 | |
| C | SER42 | |
| D | SER29 | |
| D | SER42 |
