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3UA4

Crystal Structure of Protein Arginine Methyltransferase PRMT5

Functional Information from GO Data
ChainGOidnamespacecontents
A0002039molecular_functionp53 binding
A0005634cellular_componentnucleus
A0005829cellular_componentcytosol
A0006325biological_processchromatin organization
A0006338biological_processchromatin remodeling
A0006355biological_processregulation of DNA-templated transcription
A0006479biological_processprotein methylation
A0006915biological_processapoptotic process
A0006974biological_processDNA damage response
A0007626biological_processlocomotory behavior
A0008168molecular_functionmethyltransferase activity
A0008469molecular_functionhistone arginine N-methyltransferase activity
A0008630biological_processintrinsic apoptotic signaling pathway in response to DNA damage
A0016274molecular_functionprotein-arginine N-methyltransferase activity
A0016740molecular_functiontransferase activity
A0017053cellular_componenttranscription repressor complex
A0018216biological_processpeptidyl-arginine methylation
A0032259biological_processmethylation
A0035241molecular_functionprotein-arginine omega-N monomethyltransferase activity
A0035243molecular_functionprotein-arginine omega-N symmetric methyltransferase activity
A0035246biological_processpeptidyl-arginine N-methylation
A0042054molecular_functionhistone methyltransferase activity
A0043518biological_processnegative regulation of DNA damage response, signal transduction by p53 class mediator
A0044020molecular_functionhistone H4R3 methyltransferase activity
A0045892biological_processnegative regulation of DNA-templated transcription
A0140297molecular_functionDNA-binding transcription factor binding
A0140940molecular_functionhistone H2A methyltransferase activity
A1990834biological_processresponse to odorant
B0002039molecular_functionp53 binding
B0005634cellular_componentnucleus
B0005829cellular_componentcytosol
B0006325biological_processchromatin organization
B0006338biological_processchromatin remodeling
B0006355biological_processregulation of DNA-templated transcription
B0006479biological_processprotein methylation
B0006915biological_processapoptotic process
B0006974biological_processDNA damage response
B0007626biological_processlocomotory behavior
B0008168molecular_functionmethyltransferase activity
B0008469molecular_functionhistone arginine N-methyltransferase activity
B0008630biological_processintrinsic apoptotic signaling pathway in response to DNA damage
B0016274molecular_functionprotein-arginine N-methyltransferase activity
B0016740molecular_functiontransferase activity
B0017053cellular_componenttranscription repressor complex
B0018216biological_processpeptidyl-arginine methylation
B0032259biological_processmethylation
B0035241molecular_functionprotein-arginine omega-N monomethyltransferase activity
B0035243molecular_functionprotein-arginine omega-N symmetric methyltransferase activity
B0035246biological_processpeptidyl-arginine N-methylation
B0042054molecular_functionhistone methyltransferase activity
B0043518biological_processnegative regulation of DNA damage response, signal transduction by p53 class mediator
B0044020molecular_functionhistone H4R3 methyltransferase activity
B0045892biological_processnegative regulation of DNA-templated transcription
B0140297molecular_functionDNA-binding transcription factor binding
B0140940molecular_functionhistone H2A methyltransferase activity
B1990834biological_processresponse to odorant
Functional Information from PDB Data
site_idAC1
Number of Residues2
DetailsBINDING SITE FOR RESIDUE GOL B 743
ChainResidue
BPRO96
BASP137

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues410
DetailsRegion: {"description":"Beta barrel","evidences":[{"source":"PubMed","id":"22143770","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI2
Number of Residues96
DetailsRegion: {"description":"Dimerization","evidences":[{"source":"PubMed","id":"22143770","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI3
Number of Residues4
DetailsActive site: {"description":"Proton donor/acceptor","evidences":[{"source":"PubMed","id":"22143770","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails

site_idSWS_FT_FI4
Number of Residues10
DetailsBinding site: {"evidences":[{"source":"UniProtKB","id":"O14744","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

239149

PDB entries from 2025-07-23

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