Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

3U9S

Crystal structure of P. aeruginosa 3-methylcrotonyl-CoA carboxylase (MCC) 750 kD holoenzyme, CoA complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0004485	molecular_function	methylcrotonoyl-CoA carboxylase activity
A	0004658	molecular_function	propionyl-CoA carboxylase activity
A	0004847	molecular_function	urea carboxylase activity
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0006552	biological_process	L-leucine catabolic process
A	0008300	biological_process	isoprenoid catabolic process
A	0016874	molecular_function	ligase activity
A	0046247	biological_process	terpene catabolic process
A	0046872	molecular_function	metal ion binding
A	1905202	cellular_component	methylcrotonoyl-CoA carboxylase complex
B	0004485	molecular_function	methylcrotonoyl-CoA carboxylase activity
B	0005515	molecular_function	protein binding
B	0006552	biological_process	L-leucine catabolic process
B	0008300	biological_process	isoprenoid catabolic process
B	0016874	molecular_function	ligase activity
B	1905202	cellular_component	methylcrotonoyl-CoA carboxylase complex
C	0000166	molecular_function	nucleotide binding
C	0004485	molecular_function	methylcrotonoyl-CoA carboxylase activity
C	0004658	molecular_function	propionyl-CoA carboxylase activity
C	0004847	molecular_function	urea carboxylase activity
C	0005515	molecular_function	protein binding
C	0005524	molecular_function	ATP binding
C	0006552	biological_process	L-leucine catabolic process
C	0008300	biological_process	isoprenoid catabolic process
C	0016874	molecular_function	ligase activity
C	0046247	biological_process	terpene catabolic process
C	0046872	molecular_function	metal ion binding
C	1905202	cellular_component	methylcrotonoyl-CoA carboxylase complex
D	0004485	molecular_function	methylcrotonoyl-CoA carboxylase activity
D	0005515	molecular_function	protein binding
D	0006552	biological_process	L-leucine catabolic process
D	0008300	biological_process	isoprenoid catabolic process
D	0016874	molecular_function	ligase activity
D	1905202	cellular_component	methylcrotonoyl-CoA carboxylase complex
E	0000166	molecular_function	nucleotide binding
E	0004485	molecular_function	methylcrotonoyl-CoA carboxylase activity
E	0004658	molecular_function	propionyl-CoA carboxylase activity
E	0004847	molecular_function	urea carboxylase activity
E	0005515	molecular_function	protein binding
E	0005524	molecular_function	ATP binding
E	0006552	biological_process	L-leucine catabolic process
E	0008300	biological_process	isoprenoid catabolic process
E	0016874	molecular_function	ligase activity
E	0046247	biological_process	terpene catabolic process
E	0046872	molecular_function	metal ion binding
E	1905202	cellular_component	methylcrotonoyl-CoA carboxylase complex
F	0004485	molecular_function	methylcrotonoyl-CoA carboxylase activity
F	0005515	molecular_function	protein binding
F	0006552	biological_process	L-leucine catabolic process
F	0008300	biological_process	isoprenoid catabolic process
F	0016874	molecular_function	ligase activity
F	1905202	cellular_component	methylcrotonoyl-CoA carboxylase complex
G	0000166	molecular_function	nucleotide binding
G	0004485	molecular_function	methylcrotonoyl-CoA carboxylase activity
G	0004658	molecular_function	propionyl-CoA carboxylase activity
G	0004847	molecular_function	urea carboxylase activity
G	0005515	molecular_function	protein binding
G	0005524	molecular_function	ATP binding
G	0006552	biological_process	L-leucine catabolic process
G	0008300	biological_process	isoprenoid catabolic process
G	0016874	molecular_function	ligase activity
G	0046247	biological_process	terpene catabolic process
G	0046872	molecular_function	metal ion binding
G	1905202	cellular_component	methylcrotonoyl-CoA carboxylase complex
H	0004485	molecular_function	methylcrotonoyl-CoA carboxylase activity
H	0005515	molecular_function	protein binding
H	0006552	biological_process	L-leucine catabolic process
H	0008300	biological_process	isoprenoid catabolic process
H	0016874	molecular_function	ligase activity
H	1905202	cellular_component	methylcrotonoyl-CoA carboxylase complex
I	0000166	molecular_function	nucleotide binding
I	0004485	molecular_function	methylcrotonoyl-CoA carboxylase activity
I	0004658	molecular_function	propionyl-CoA carboxylase activity
I	0004847	molecular_function	urea carboxylase activity
I	0005515	molecular_function	protein binding
I	0005524	molecular_function	ATP binding
I	0006552	biological_process	L-leucine catabolic process
I	0008300	biological_process	isoprenoid catabolic process
I	0016874	molecular_function	ligase activity
I	0046247	biological_process	terpene catabolic process
I	0046872	molecular_function	metal ion binding
I	1905202	cellular_component	methylcrotonoyl-CoA carboxylase complex
J	0004485	molecular_function	methylcrotonoyl-CoA carboxylase activity
J	0005515	molecular_function	protein binding
J	0006552	biological_process	L-leucine catabolic process
J	0008300	biological_process	isoprenoid catabolic process
J	0016874	molecular_function	ligase activity
J	1905202	cellular_component	methylcrotonoyl-CoA carboxylase complex
K	0000166	molecular_function	nucleotide binding
K	0004485	molecular_function	methylcrotonoyl-CoA carboxylase activity
K	0004658	molecular_function	propionyl-CoA carboxylase activity
K	0004847	molecular_function	urea carboxylase activity
K	0005515	molecular_function	protein binding
K	0005524	molecular_function	ATP binding
K	0006552	biological_process	L-leucine catabolic process
K	0008300	biological_process	isoprenoid catabolic process
K	0016874	molecular_function	ligase activity
K	0046247	biological_process	terpene catabolic process
K	0046872	molecular_function	metal ion binding
K	1905202	cellular_component	methylcrotonoyl-CoA carboxylase complex
L	0004485	molecular_function	methylcrotonoyl-CoA carboxylase activity
L	0005515	molecular_function	protein binding
L	0006552	biological_process	L-leucine catabolic process
L	0008300	biological_process	isoprenoid catabolic process
L	0016874	molecular_function	ligase activity
L	1905202	cellular_component	methylcrotonoyl-CoA carboxylase complex

Functional Information from PDB Data

site_id	AC1
Number of Residues	7
Details	BINDING SITE FOR RESIDUE BTI A 801

Chain	Residue
A	LYS681
F	THR405
F	GLY406
F	PHE407
F	ALA447
F	GLY474
H	LEU246

site_id	AC2
Number of Residues	15
Details	BINDING SITE FOR RESIDUE COA B 591

Chain	Residue
B	LYS141
B	THR144
B	GLY174
B	ALA176
B	ASN177
B	LEU178
B	PRO179
B	THR217
B	PRO245
B	LEU246
L	LEU482
L	VAL485
L	GLN489
B	ARG74
B	ARG78

site_id	AC3
Number of Residues	13
Details	BINDING SITE FOR RESIDUE COA D 591

Chain	Residue
D	ARG74
D	ARG78
D	LYS141
D	THR144
D	GLY174
D	GLY175
D	ALA176
D	LEU178
D	PRO179
D	THR217
J	VAL485
J	GLN489
J	ARG492

site_id	AC4
Number of Residues	14
Details	BINDING SITE FOR RESIDUE COA F 591

Chain	Residue
F	ARG74
F	LYS141
F	GLY142
F	THR144
F	ALA176
F	ASN177
F	LEU178
F	THR217
F	PRO245
F	LEU246
H	MET473
H	VAL485
H	GLN489
H	ARG492

site_id	AC5
Number of Residues	17
Details	BINDING SITE FOR RESIDUE COA H 591

Chain	Residue
F	VAL485
F	LYS486
F	GLN489
H	ARG74
H	ARG78
H	LYS141
H	GLY142
H	THR144
H	GLY174
H	ALA176
H	ASN177
H	LEU178
H	PRO179
H	THR217
H	GLY219
H	PRO245
H	LEU246

site_id	AC6
Number of Residues	16
Details	BINDING SITE FOR RESIDUE COA J 591

Chain	Residue
D	LEU482
D	VAL485
D	LYS486
D	ARG492
J	ARG74
J	ARG78
J	LYS141
J	THR144
J	GLY174
J	ALA176
J	ASN177
J	LEU178
J	PRO179
J	THR217
J	ALA218
J	LEU246

site_id	AC7
Number of Residues	14
Details	BINDING SITE FOR RESIDUE COA L 591

Chain	Residue
B	VAL485
B	GLN489
B	ARG492
L	ARG74
L	LYS141
L	GLY142
L	THR144
L	GLY174
L	GLY175
L	ALA176
L	ASN177
L	LEU178
L	THR217
L	PRO245

site_id	AC8
Number of Residues	10
Details	BINDING SITE FOR RESIDUE BTI I 801

Chain	Residue
H	GLY406
H	PHE407
H	GLY446
H	ALA447
H	MET473
H	GLN477
I	LYS681
F	ALA218
F	LEU241
H	THR405

Functional Information from PROSITE/UniProt

site_id	PS00866
Number of Residues	15
Details	CPSASE_1 Carbamoyl-phosphate synthase subdomain signature 1. YPVLLKAAaggGGkG

Chain	Residue	Details
A	TYR200-GLY214

site_id	PS00867
Number of Residues	8
Details	CPSASE_2 Carbamoyl-phosphate synthase subdomain signature 2. FMEMNTRL

Chain	Residue	Details
A	PHE333-LEU340

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)