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3U9H

Complex structure of human tankyrase 2 with nicotinamide

Functional Information from GO Data
ChainGOidnamespacecontents
A0003950molecular_functionNAD+-protein poly-ADP-ribosyltransferase activity
B0003950molecular_functionNAD+-protein poly-ADP-ribosyltransferase activity
Functional Information from PDB Data
site_idAC1
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN A 1
ChainResidue
ACYS1081
AHIS1084
ACYS1089
ACYS1092

site_idAC2
Number of Residues7
DetailsBINDING SITE FOR RESIDUE SO4 A 3
ChainResidue
ALYS1067
AGLN1070
AHOH246
AHOH334
AARG977
AHIS979
AARG980

site_idAC3
Number of Residues7
DetailsBINDING SITE FOR RESIDUE SO4 A 4
ChainResidue
AHOH70
AHOH285
AHOH327
AASN990
AARG991
APRO1160
AGLU1161

site_idAC4
Number of Residues10
DetailsBINDING SITE FOR RESIDUE NCA A 1163
ChainResidue
AHOH226
AHOH306
AHIS1031
AGLY1032
ATYR1060
APHE1061
AALA1062
ASER1068
ATYR1071
AGLU1138

site_idAC5
Number of Residues6
DetailsBINDING SITE FOR RESIDUE GOL A 1164
ChainResidue
AARG1128
APRO1129
ASER1130
AVAL1131
AASN1132
AGLY1133

site_idAC6
Number of Residues5
DetailsBINDING SITE FOR RESIDUE PEG A 2
ChainResidue
ACYS1001
AASN1002
ATRP1006
ATYR1148
AGLU1150

site_idAC7
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN B 2
ChainResidue
BCYS1081
BHIS1084
BCYS1089
BCYS1092

site_idAC8
Number of Residues4
DetailsBINDING SITE FOR RESIDUE SO4 B 1
ChainResidue
BHOH26
BASN990
BARG991
BGLU1161

site_idAC9
Number of Residues7
DetailsBINDING SITE FOR RESIDUE SO4 B 1163
ChainResidue
BHOH143
BHOH192
BARG977
BHIS979
BARG980
BLYS1067
BGLN1070

site_idBC1
Number of Residues11
DetailsBINDING SITE FOR RESIDUE NCA B 1164
ChainResidue
BHOH268
BHOH303
BHOH304
BHOH305
BHIS1031
BGLY1032
BTYR1060
BPHE1061
BSER1068
BTYR1071
BGLU1138

site_idBC2
Number of Residues5
DetailsBINDING SITE FOR RESIDUE PEG B 1165
ChainResidue
BLYS999
BTRP1006
BASN1022
BTYR1148
BGLU1150

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues8
DetailsBINDING: BINDING => ECO:0000250|UniProtKB:O95271
ChainResidueDetails
ACYS1081
AHIS1084
ACYS1089
ACYS1092
BCYS1081
BHIS1084
BCYS1089
BCYS1092

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PDB entries from 2024-11-06

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