3U9D
Crystal Structure of a chimera containing the N-terminal domain (residues 8-24) of drosophila Ciboulot and the C-terminal domain (residues 13-44) of bovine Thymosin-beta4, bound to G-actin-ATP
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0001725 | cellular_component | stress fiber |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005856 | cellular_component | cytoskeleton |
| A | 0005865 | cellular_component | striated muscle thin filament |
| A | 0005884 | cellular_component | actin filament |
| A | 0009612 | biological_process | response to mechanical stimulus |
| A | 0010628 | biological_process | positive regulation of gene expression |
| A | 0015629 | cellular_component | actin cytoskeleton |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0030017 | cellular_component | sarcomere |
| A | 0030027 | cellular_component | lamellipodium |
| A | 0030175 | cellular_component | filopodium |
| A | 0030240 | biological_process | skeletal muscle thin filament assembly |
| A | 0035865 | biological_process | cellular response to potassium ion |
| A | 0043503 | biological_process | skeletal muscle fiber adaptation |
| A | 0044297 | cellular_component | cell body |
| A | 0048545 | biological_process | response to steroid hormone |
| A | 0048741 | biological_process | skeletal muscle fiber development |
| A | 0090131 | biological_process | mesenchyme migration |
| B | 0003785 | molecular_function | actin monomer binding |
| B | 0007015 | biological_process | actin filament organization |
| C | 0001725 | cellular_component | stress fiber |
| C | 0005524 | molecular_function | ATP binding |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0005856 | cellular_component | cytoskeleton |
| C | 0005865 | cellular_component | striated muscle thin filament |
| C | 0005884 | cellular_component | actin filament |
| C | 0009612 | biological_process | response to mechanical stimulus |
| C | 0010628 | biological_process | positive regulation of gene expression |
| C | 0015629 | cellular_component | actin cytoskeleton |
| C | 0016787 | molecular_function | hydrolase activity |
| C | 0030017 | cellular_component | sarcomere |
| C | 0030027 | cellular_component | lamellipodium |
| C | 0030175 | cellular_component | filopodium |
| C | 0030240 | biological_process | skeletal muscle thin filament assembly |
| C | 0035865 | biological_process | cellular response to potassium ion |
| C | 0043503 | biological_process | skeletal muscle fiber adaptation |
| C | 0044297 | cellular_component | cell body |
| C | 0048545 | biological_process | response to steroid hormone |
| C | 0048741 | biological_process | skeletal muscle fiber development |
| C | 0090131 | biological_process | mesenchyme migration |
| D | 0003785 | molecular_function | actin monomer binding |
| D | 0007015 | biological_process | actin filament organization |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 19 |
| Details | BINDING SITE FOR RESIDUE ATP A 501 |
| Chain | Residue |
| A | GLY13 |
| A | GLY182 |
| A | ARG210 |
| A | LYS213 |
| A | GLU214 |
| A | GLY301 |
| A | GLY302 |
| A | THR303 |
| A | MET305 |
| A | TYR306 |
| A | MG502 |
| A | SER14 |
| A | GLY15 |
| A | LEU16 |
| A | LYS18 |
| A | GLY156 |
| A | ASP157 |
| A | GLY158 |
| A | VAL159 |
| site_id | AC2 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE MG A 502 |
| Chain | Residue |
| A | GLN137 |
| A | ATP501 |
| site_id | AC3 |
| Number of Residues | 18 |
| Details | BINDING SITE FOR RESIDUE ATP C 501 |
| Chain | Residue |
| C | GLY13 |
| C | SER14 |
| C | GLY15 |
| C | LEU16 |
| C | LYS18 |
| C | GLN137 |
| C | ASP154 |
| C | GLY156 |
| C | ASP157 |
| C | GLY182 |
| C | LYS213 |
| C | GLU214 |
| C | GLY302 |
| C | THR303 |
| C | MET305 |
| C | TYR306 |
| C | LYS336 |
| C | MG502 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MG C 502 |
| Chain | Residue |
| C | ASP11 |
| C | GLY13 |
| C | GLN137 |
| C | ATP501 |
Functional Information from PROSITE/UniProt
| site_id | PS00406 |
| Number of Residues | 11 |
| Details | ACTINS_1 Actins signature 1. YVGDEAQs.KRG |
| Chain | Residue | Details |
| A | TYR53-GLY63 |
| site_id | PS00432 |
| Number of Residues | 9 |
| Details | ACTINS_2 Actins signature 2. WITKqEYDE |
| Chain | Residue | Details |
| A | TRP356-GLU364 |
| site_id | PS00500 |
| Number of Residues | 12 |
| Details | THYMOSIN_B4 Thymosin beta-4 family signature. LKKTETqeKNPL |
| Chain | Residue | Details |
| B | LEU30-LEU41 |
| site_id | PS01132 |
| Number of Residues | 13 |
| Details | ACTINS_ACT_LIKE Actins and actin-related proteins signature. LLTEApLNPkaNR |
| Chain | Residue | Details |
| A | LEU104-ARG116 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | MOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:P62328 |
| Chain | Residue | Details |
| B | THR35 | |
| B | THR46 | |
| D | THR35 | |
| D | THR46 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 6 |
| Details | MOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:P62328 |
| Chain | Residue | Details |
| B | LYS38 | |
| B | LYS44 | |
| B | LYS51 | |
| D | LYS38 | |
| D | LYS44 | |
| D | LYS51 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P62328 |
| Chain | Residue | Details |
| B | SER43 | |
| D | SER43 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | MOD_RES: N6-methyllysine => ECO:0000250|UniProtKB:P68133 |
| Chain | Residue | Details |
| A | LYS84 | |
| C | LYS84 |
