3U8O
Human thrombin complexed with D-Phe-Pro-D-Arg-D-Thr
Functional Information from GO Data
Chain | GOid | namespace | contents |
H | 0004252 | molecular_function | serine-type endopeptidase activity |
H | 0005509 | molecular_function | calcium ion binding |
H | 0006508 | biological_process | proteolysis |
H | 0007596 | biological_process | blood coagulation |
L | 0004252 | molecular_function | serine-type endopeptidase activity |
L | 0005576 | cellular_component | extracellular region |
L | 0006508 | biological_process | proteolysis |
L | 0007596 | biological_process | blood coagulation |
Functional Information from PROSITE/UniProt
site_id | PS00134 |
Number of Residues | 6 |
Details | TRYPSIN_HIS Serine proteases, trypsin family, histidine active site. LTAAHC |
Chain | Residue | Details |
H | LEU359-CYS364 |
site_id | PS00135 |
Number of Residues | 12 |
Details | TRYPSIN_SER Serine proteases, trypsin family, serine active site. DAceGDSGGPFV |
Chain | Residue | Details |
H | ASP519-VAL530 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 1 |
Details | SITE: Cleavage; by factor Xa => ECO:0000269|PubMed:34265300 |
Chain | Residue | Details |
L | ARG320 | |
H | ASP419 | |
H | SER525 |
site_id | SWS_FT_FI2 |
Number of Residues | 1 |
Details | CARBOHYD: N-linked (GlcNAc...) (complex) asparagine => ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:19139490, ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:19838169, ECO:0000269|PubMed:873923 |
Chain | Residue | Details |
H | ASN373 |