3U61

Structure of T4 Bacteriophage Clamp Loader Bound To Closed Clamp, DNA and ATP Analog and ADP

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003677	molecular_function	DNA binding
A	0003689	molecular_function	DNA clamp loader activity
A	0006260	biological_process	DNA replication
A	0039686	biological_process	bidirectional double-stranded viral DNA replication
A	0039693	biological_process	viral DNA genome replication
B	0003677	molecular_function	DNA binding
B	0003689	molecular_function	DNA clamp loader activity
B	0005524	molecular_function	ATP binding
B	0005663	cellular_component	DNA replication factor C complex
B	0006260	biological_process	DNA replication
B	0006261	biological_process	DNA-templated DNA replication
B	0006281	biological_process	DNA repair
B	0016787	molecular_function	hydrolase activity
B	0016887	molecular_function	ATP hydrolysis activity
B	0039686	biological_process	bidirectional double-stranded viral DNA replication
B	0039693	biological_process	viral DNA genome replication
C	0003677	molecular_function	DNA binding
C	0003689	molecular_function	DNA clamp loader activity
C	0005524	molecular_function	ATP binding
C	0005663	cellular_component	DNA replication factor C complex
C	0006260	biological_process	DNA replication
C	0006261	biological_process	DNA-templated DNA replication
C	0006281	biological_process	DNA repair
C	0016787	molecular_function	hydrolase activity
C	0016887	molecular_function	ATP hydrolysis activity
C	0039686	biological_process	bidirectional double-stranded viral DNA replication
C	0039693	biological_process	viral DNA genome replication
D	0003677	molecular_function	DNA binding
D	0003689	molecular_function	DNA clamp loader activity
D	0005524	molecular_function	ATP binding
D	0005663	cellular_component	DNA replication factor C complex
D	0006260	biological_process	DNA replication
D	0006261	biological_process	DNA-templated DNA replication
D	0006281	biological_process	DNA repair
D	0016787	molecular_function	hydrolase activity
D	0016887	molecular_function	ATP hydrolysis activity
D	0039686	biological_process	bidirectional double-stranded viral DNA replication
D	0039693	biological_process	viral DNA genome replication
E	0003677	molecular_function	DNA binding
E	0003689	molecular_function	DNA clamp loader activity
E	0005524	molecular_function	ATP binding
E	0005663	cellular_component	DNA replication factor C complex
E	0006260	biological_process	DNA replication
E	0006261	biological_process	DNA-templated DNA replication
E	0006281	biological_process	DNA repair
E	0016787	molecular_function	hydrolase activity
E	0016887	molecular_function	ATP hydrolysis activity
E	0039686	biological_process	bidirectional double-stranded viral DNA replication
E	0039693	biological_process	viral DNA genome replication
F	0006260	biological_process	DNA replication
F	0019083	biological_process	viral transcription
F	0030337	molecular_function	DNA polymerase processivity factor activity
F	0039686	biological_process	bidirectional double-stranded viral DNA replication
F	0039693	biological_process	viral DNA genome replication
G	0006260	biological_process	DNA replication
G	0019083	biological_process	viral transcription
G	0030337	molecular_function	DNA polymerase processivity factor activity
G	0039686	biological_process	bidirectional double-stranded viral DNA replication
G	0039693	biological_process	viral DNA genome replication
H	0006260	biological_process	DNA replication
H	0019083	biological_process	viral transcription
H	0030337	molecular_function	DNA polymerase processivity factor activity
H	0039686	biological_process	bidirectional double-stranded viral DNA replication
H	0039693	biological_process	viral DNA genome replication

Functional Information from PDB Data

site_id	AC1
Number of Residues	15
Details	BINDING SITE FOR RESIDUE ADP B 700

Chain	Residue
B	GLU12
B	THR57
B	THR58
B	PHE204
B	ARG205
B	ILE208
B	MG800
B	TYR15
B	ARG16
B	PRO17
B	ILE24
B	GLY53
B	THR54
B	GLY55
B	LYS56

---

site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG B 800

Chain	Residue
B	THR57
B	ASP107
B	GLU108
B	ARG205
B	ADP700

---

site_id	AC3
Number of Residues	18
Details	BINDING SITE FOR RESIDUE 08T C 700

Chain	Residue
C	GLU12
C	ARG16
C	PRO17
C	ILE24
C	PRO52
C	GLY53
C	THR54
C	GLY55
C	LYS56
C	THR57
C	THR58
C	GLU108
C	ASN139
C	PHE204
C	ARG205
C	MG800
D	GLU126
D	ARG151

---

site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MG C 800

Chain	Residue
C	THR57
C	GLU108
C	08T700
D	ARG151

---

site_id	AC5
Number of Residues	17
Details	BINDING SITE FOR RESIDUE 08T D 700

Chain	Residue
D	GLU12
D	ARG16
D	ILE24
D	PRO52
D	GLY53
D	THR54
D	GLY55
D	LYS56
D	THR57
D	THR58
D	GLU108
D	ASN139
D	PHE204
D	ARG205
D	MG800
E	GLU126
E	ARG151

---

site_id	AC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MG D 800

Chain	Residue
D	THR57
D	GLU108
D	08T700
E	GLU126

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	16
Details	BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_04162, ECO:0000269|PubMed:22194570

Chain	Residue	Details
B	GLU12
D	ILE24
D	GLY53
D	ARG205
E	GLU12
E	ILE24
E	GLY53
E	ARG205
B	ILE24
B	GLY53
B	ARG205
C	GLU12
C	ILE24
C	GLY53
C	ARG205
D	GLU12

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