Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

3U5O

Crystal structure of the complex of TRIM33 PHD-Bromo and H3(1-22)K9me3K14acK18ac histone peptide

Functional Information from GO Data

Chain	GOid	namespace	contents
I	0000786	cellular_component	nucleosome
I	0003677	molecular_function	DNA binding
I	0030527	molecular_function	structural constituent of chromatin
J	0000786	cellular_component	nucleosome
J	0003677	molecular_function	DNA binding
J	0030527	molecular_function	structural constituent of chromatin
K	0000786	cellular_component	nucleosome
K	0003677	molecular_function	DNA binding
K	0030527	molecular_function	structural constituent of chromatin
L	0000786	cellular_component	nucleosome
L	0003677	molecular_function	DNA binding
L	0030527	molecular_function	structural constituent of chromatin
M	0000786	cellular_component	nucleosome
M	0003677	molecular_function	DNA binding
M	0030527	molecular_function	structural constituent of chromatin
N	0000786	cellular_component	nucleosome
N	0003677	molecular_function	DNA binding
N	0030527	molecular_function	structural constituent of chromatin
O	0000786	cellular_component	nucleosome
O	0003677	molecular_function	DNA binding
O	0030527	molecular_function	structural constituent of chromatin
P	0000786	cellular_component	nucleosome
P	0003677	molecular_function	DNA binding
P	0030527	molecular_function	structural constituent of chromatin

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 1

Chain	Residue
A	CYS890
A	CYS893
A	HIS910
A	CYS913

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 2

Chain	Residue
A	CYS902
A	CYS905
A	CYS928
A	CYS931

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN B 1

Chain	Residue
B	CYS893
B	HIS910
B	CYS913
B	CYS890

site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN B 2

Chain	Residue
B	CYS902
B	CYS905
B	CYS928
B	CYS931

site_id	AC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN C 1

Chain	Residue
C	CYS890
C	CYS893
C	HIS910
C	CYS913

site_id	AC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN C 2

Chain	Residue
C	CYS902
C	CYS905
C	CYS928
C	CYS931

site_id	AC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN D 1

Chain	Residue
D	CYS890
D	CYS893
D	HIS910
D	CYS913

site_id	AC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN D 2

Chain	Residue
D	CYS902
D	CYS905
D	CYS928
D	CYS931

site_id	AC9
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN E 1

Chain	Residue
E	CYS890
E	CYS893
E	HIS910
E	CYS913

site_id	BC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN E 2

Chain	Residue
E	CYS902
E	CYS905
E	CYS928
E	CYS931

site_id	BC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN F 1

Chain	Residue
F	CYS890
F	CYS893
F	HIS910
F	CYS913

site_id	BC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN F 2

Chain	Residue
F	CYS902
F	CYS905
F	CYS928
F	CYS931

site_id	BC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN G 1

Chain	Residue
G	CYS890
G	CYS893
G	HIS910
G	CYS913

site_id	BC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN G 2

Chain	Residue
G	CYS902
G	CYS905
G	CYS928
G	CYS931

site_id	BC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN H 1

Chain	Residue
H	CYS890
H	CYS893
H	HIS910
H	CYS913

site_id	BC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN H 2

Chain	Residue
H	CYS902
H	CYS905
H	CYS928
H	CYS931

Functional Information from PROSITE/UniProt

site_id	PS00322
Number of Residues	7
Details	HISTONE_H3_1 Histone H3 signature 1. KAPRKQL

Chain	Residue	Details
I	ALY14-LEU20

site_id	PS01359
Number of Residues	42
Details	ZF_PHD_1 Zinc finger PHD-type signature. CavCqnggdl.......................................LcCek..Cpkv.FHltChvptllsfpsgd.................................WiCtfC

Chain	Residue	Details
A	CYS890-CYS931

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	376
Details	Zinc finger: {"description":"PHD-type","evidences":[{"source":"PROSITE-ProRule","id":"PRU00146","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	8
Details	Site: {"description":"Breakpoint for translocation to form TRIM33-RET oncogene"}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	8
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"25218447","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	16
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	3
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"Q99PP7","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	1
Details	Modified residue: {"description":"N6-acetyllysine; alternate","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	1
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate","evidences":[{"source":"PubMed","id":"25218447","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	8
Details	Modified residue: {"description":"Citrulline; alternate","evidences":[{"source":"PubMed","id":"16567635","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	8
Details	Modified residue: {"description":"Phosphothreonine; by HASPIN and VRK1","evidences":[{"source":"PubMed","id":"15681610","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16185088","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31527692","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI10
Number of Residues	8
Details	Modified residue: {"description":"N6-methyllysine; alternate","evidences":[{"source":"PubMed","id":"16267050","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16457588","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17194708","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI11
Number of Residues	8
Details	Modified residue: {"description":"5-glutamyl serotonin; alternate","evidences":[{"source":"PubMed","id":"30867594","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI12
Number of Residues	8
Details	Modified residue: {"description":"Phosphothreonine; by PKC","evidences":[{"source":"PubMed","id":"20228790","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI13
Number of Residues	8
Details	Modified residue: {"description":"Symmetric dimethylarginine; by PRMT5; alternate","evidences":[{"source":"UniProtKB","id":"P68433","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI14
Number of Residues	8
Details	Modified residue: {"description":"N6-methyllysine; alternate","evidences":[{"source":"PubMed","id":"11242053","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16185088","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16267050","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16457588","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17194708","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI15
Number of Residues	8
Details	Modified residue: {"description":"Phosphoserine; alternate; by AURKB, AURKC, RPS6KA3, RPS6KA4 and RPS6KA5","evidences":[{"source":"PubMed","id":"10464286","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"11856369","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"12560483","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15681610","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16185088","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16457588","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI16
Number of Residues	8
Details	Modified residue: {"description":"Phosphothreonine; by PKC and CHEK1","evidences":[{"source":"PubMed","id":"12560483","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18066052","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18243098","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22901803","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)