3U40
Crystal structure of a purine nucleoside phosphorylase from Entamoeba histolytica bound to adenosine
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0004731 | molecular_function | purine-nucleoside phosphorylase activity |
| A | 0004850 | molecular_function | uridine phosphorylase activity |
| A | 0005829 | cellular_component | cytosol |
| A | 0006139 | biological_process | nucleobase-containing compound metabolic process |
| A | 0006218 | biological_process | uridine catabolic process |
| A | 0009116 | biological_process | nucleoside metabolic process |
| B | 0003824 | molecular_function | catalytic activity |
| B | 0004731 | molecular_function | purine-nucleoside phosphorylase activity |
| B | 0004850 | molecular_function | uridine phosphorylase activity |
| B | 0005829 | cellular_component | cytosol |
| B | 0006139 | biological_process | nucleobase-containing compound metabolic process |
| B | 0006218 | biological_process | uridine catabolic process |
| B | 0009116 | biological_process | nucleoside metabolic process |
| C | 0003824 | molecular_function | catalytic activity |
| C | 0004731 | molecular_function | purine-nucleoside phosphorylase activity |
| C | 0004850 | molecular_function | uridine phosphorylase activity |
| C | 0005829 | cellular_component | cytosol |
| C | 0006139 | biological_process | nucleobase-containing compound metabolic process |
| C | 0006218 | biological_process | uridine catabolic process |
| C | 0009116 | biological_process | nucleoside metabolic process |
| D | 0003824 | molecular_function | catalytic activity |
| D | 0004731 | molecular_function | purine-nucleoside phosphorylase activity |
| D | 0004850 | molecular_function | uridine phosphorylase activity |
| D | 0005829 | cellular_component | cytosol |
| D | 0006139 | biological_process | nucleobase-containing compound metabolic process |
| D | 0006218 | biological_process | uridine catabolic process |
| D | 0009116 | biological_process | nucleoside metabolic process |
| E | 0003824 | molecular_function | catalytic activity |
| E | 0004731 | molecular_function | purine-nucleoside phosphorylase activity |
| E | 0004850 | molecular_function | uridine phosphorylase activity |
| E | 0005829 | cellular_component | cytosol |
| E | 0006139 | biological_process | nucleobase-containing compound metabolic process |
| E | 0006218 | biological_process | uridine catabolic process |
| E | 0009116 | biological_process | nucleoside metabolic process |
| F | 0003824 | molecular_function | catalytic activity |
| F | 0004731 | molecular_function | purine-nucleoside phosphorylase activity |
| F | 0004850 | molecular_function | uridine phosphorylase activity |
| F | 0005829 | cellular_component | cytosol |
| F | 0006139 | biological_process | nucleobase-containing compound metabolic process |
| F | 0006218 | biological_process | uridine catabolic process |
| F | 0009116 | biological_process | nucleoside metabolic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE ADN A 251 |
| Chain | Residue |
| A | SER95 |
| A | HOH464 |
| A | HOH476 |
| F | HIS9 |
| F | HOH301 |
| A | GLY97 |
| A | PHE164 |
| A | VAL182 |
| A | GLU183 |
| A | MET184 |
| A | GLU185 |
| A | HOH276 |
| A | HOH461 |
| site_id | AC2 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE ADN B 251 |
| Chain | Residue |
| B | SER95 |
| B | ALA96 |
| B | GLY97 |
| B | PHE164 |
| B | VAL182 |
| B | MET184 |
| B | GLU185 |
| B | HOH266 |
| B | HOH274 |
| B | HOH469 |
| B | HOH470 |
| B | HOH483 |
| C | HIS9 |
| site_id | AC3 |
| Number of Residues | 16 |
| Details | BINDING SITE FOR RESIDUE ADN C 251 |
| Chain | Residue |
| B | HIS9 |
| B | ARG48 |
| C | ARG92 |
| C | SER95 |
| C | ALA96 |
| C | GLY97 |
| C | PHE164 |
| C | VAL182 |
| C | GLU183 |
| C | MET184 |
| C | GLU185 |
| C | ASP208 |
| C | CYS210 |
| C | HOH267 |
| C | HOH280 |
| C | HOH485 |
| site_id | AC4 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE ADN D 251 |
| Chain | Residue |
| D | MET69 |
| D | ARG92 |
| D | SER95 |
| D | ALA96 |
| D | GLY97 |
| D | PHE164 |
| D | GLU183 |
| D | MET184 |
| D | GLU185 |
| D | ASP208 |
| D | PO4239 |
| D | HOH489 |
| E | HIS9 |
| E | ARG48 |
| site_id | AC5 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE ADN E 251 |
| Chain | Residue |
| D | HIS9 |
| D | ARG48 |
| E | ARG92 |
| E | SER95 |
| E | ALA96 |
| E | GLY97 |
| E | PHE164 |
| E | VAL182 |
| E | GLU183 |
| E | MET184 |
| E | GLU185 |
| E | ASP208 |
| E | HOH260 |
| E | HOH420 |
| site_id | AC6 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE ADN F 251 |
| Chain | Residue |
| A | HIS9 |
| A | ARG48 |
| F | ARG92 |
| F | SER95 |
| F | PHE164 |
| F | MET184 |
| F | GLU185 |
| F | ASP208 |
| F | HOH290 |
| F | HOH468 |
| F | HOH472 |
| F | HOH490 |
| site_id | AC7 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE PO4 D 239 |
| Chain | Residue |
| D | GLY25 |
| D | ARG29 |
| D | ARG92 |
| D | ILE93 |
| D | GLY94 |
| D | SER95 |
| D | ADN251 |
| E | ARG48 |
| site_id | AC8 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE NO3 A 239 |
| Chain | Residue |
| A | TYR14 |
| A | GLY15 |
| A | ILE17 |
| A | GLU19 |
| D | NO3241 |
| site_id | AC9 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE NO3 B 239 |
| Chain | Residue |
| B | TYR14 |
| B | ILE17 |
| B | GLU19 |
| B | TYR85 |
| site_id | BC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE NO3 C 239 |
| Chain | Residue |
| C | TYR14 |
| C | GLY15 |
| C | ILE17 |
| C | HOH350 |
| site_id | BC2 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE NO3 D 240 |
| Chain | Residue |
| D | TYR14 |
| D | GLY15 |
| D | ILE17 |
| D | GLU19 |
| D | TYR85 |
| D | GLY86 |
| D | HOH391 |
| site_id | BC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE NO3 E 239 |
| Chain | Residue |
| E | TYR14 |
| E | ILE17 |
| E | TYR85 |
| E | GLY86 |
| site_id | BC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE NO3 F 239 |
| Chain | Residue |
| F | TYR14 |
| F | ILE17 |
| F | GLU19 |
| F | TYR85 |
| site_id | BC5 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE NO3 D 241 |
| Chain | Residue |
| A | GLY15 |
| A | LYS61 |
| A | NO3239 |
| A | HOH570 |
| D | SER0 |
| D | ALA2 |
| D | HOH373 |
