3TZH
Crystal structure of 3-ketoacyl-(acyl-carrier-protein) reductase (FabG)(F187A) from Vibrio cholerae
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004316 | molecular_function | 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity |
| A | 0006633 | biological_process | fatty acid biosynthetic process |
| A | 0051287 | molecular_function | NAD binding |
| B | 0004316 | molecular_function | 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity |
| B | 0006633 | biological_process | fatty acid biosynthetic process |
| B | 0051287 | molecular_function | NAD binding |
| C | 0004316 | molecular_function | 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity |
| C | 0006633 | biological_process | fatty acid biosynthetic process |
| C | 0051287 | molecular_function | NAD binding |
| D | 0004316 | molecular_function | 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity |
| D | 0006633 | biological_process | fatty acid biosynthetic process |
| D | 0051287 | molecular_function | NAD binding |
| E | 0004316 | molecular_function | 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity |
| E | 0006633 | biological_process | fatty acid biosynthetic process |
| E | 0051287 | molecular_function | NAD binding |
| F | 0004316 | molecular_function | 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity |
| F | 0006633 | biological_process | fatty acid biosynthetic process |
| F | 0051287 | molecular_function | NAD binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 A 249 |
| Chain | Residue |
| A | ARG19 |
| A | GLY20 |
| A | LYS23 |
| A | LYS23 |
| A | HOH504 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 A 250 |
| Chain | Residue |
| A | HOH531 |
| A | GLY82 |
| A | GLY83 |
| A | LYS132 |
| A | HOH304 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 A 251 |
| Chain | Residue |
| A | LYS103 |
| A | GLU104 |
| A | LYS123 |
| A | HOH891 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL A 252 |
| Chain | Residue |
| A | GLY16 |
| A | ALA17 |
| A | SER18 |
| A | ARG19 |
| A | ALA40 |
| A | THR41 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 B 251 |
| Chain | Residue |
| B | ARG19 |
| B | GLY20 |
| B | LYS23 |
| B | LYS23 |
| B | HOH560 |
| site_id | AC6 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 B 252 |
| Chain | Residue |
| B | GLY82 |
| B | GLY83 |
| B | LYS132 |
| B | LYS132 |
| B | HOH362 |
| B | HOH384 |
| site_id | AC7 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 B 253 |
| Chain | Residue |
| B | SER18 |
| B | ARG19 |
| B | ALA40 |
| B | THR41 |
| B | HOH957 |
| site_id | AC8 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GOL B 254 |
| Chain | Residue |
| B | GLY145 |
| B | THR146 |
| B | LYS167 |
| B | LYS167 |
| B | HOH257 |
| B | HOH257 |
| B | HOH733 |
| site_id | AC9 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 C 249 |
| Chain | Residue |
| C | MET1 |
| C | SER2 |
| C | ARG32 |
| D | MET1 |
| D | SER2 |
| D | ARG32 |
| site_id | BC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 C 250 |
| Chain | Residue |
| C | LYS103 |
| C | GLU104 |
| C | LYS123 |
| C | HOH266 |
| site_id | BC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 C 251 |
| Chain | Residue |
| C | ARG19 |
| C | GLY20 |
| C | LYS23 |
| C | HOH693 |
| site_id | BC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 C 252 |
| Chain | Residue |
| C | GLY83 |
| C | GLY83 |
| C | LYS132 |
| C | HOH263 |
| C | HOH342 |
| site_id | BC4 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE SO4 C 253 |
| Chain | Residue |
| C | ILE93 |
| C | ARG95 |
| site_id | BC5 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GOL C 254 |
| Chain | Residue |
| C | GLY16 |
| C | ALA17 |
| C | SER18 |
| C | ARG19 |
| C | ALA40 |
| C | THR41 |
| C | HOH284 |
| site_id | BC6 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 D 249 |
| Chain | Residue |
| D | LYS103 |
| D | GLU104 |
| D | HOH304 |
| site_id | BC7 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 D 250 |
| Chain | Residue |
| D | ARG19 |
| D | GLY20 |
| D | LYS23 |
| D | LYS23 |
| D | HOH274 |
| site_id | BC8 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 D 251 |
| Chain | Residue |
| D | GLY82 |
| D | GLY83 |
| D | GLY83 |
| D | LYS132 |
| D | HOH277 |
| site_id | BC9 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 E 249 |
| Chain | Residue |
| B | SER2 |
| B | ARG32 |
| E | SER2 |
| E | ARG32 |
| site_id | CC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 E 250 |
| Chain | Residue |
| E | ARG19 |
| E | GLY20 |
| E | LYS23 |
| E | LYS23 |
| E | HOH633 |
| site_id | CC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL E 251 |
| Chain | Residue |
| E | GLY16 |
| E | ALA17 |
| E | SER18 |
| E | ARG19 |
| E | ALA40 |
| E | THR41 |
| site_id | CC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE GOL E 252 |
| Chain | Residue |
| E | GLY145 |
| E | ILE163 |
| E | LYS167 |
| E | HOH815 |
| site_id | CC4 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE SO4 F 249 |
| Chain | Residue |
| F | LYS103 |
| F | GLU104 |
| site_id | CC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 F 250 |
| Chain | Residue |
| F | ARG19 |
| F | GLY20 |
| F | LYS23 |
| F | HOH610 |
| site_id | CC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 F 251 |
| Chain | Residue |
| A | SER2 |
| A | ARG32 |
| F | SER2 |
| F | ARG32 |
| site_id | CC7 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE GOL F 252 |
| Chain | Residue |
| F | GLY16 |
| F | ALA17 |
| F | SER18 |
| F | ARG19 |
| F | THR39 |
| F | ALA40 |
| F | THR41 |
| F | HOH277 |
| F | HOH884 |
| site_id | CC8 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GOL F 253 |
| Chain | Residue |
| F | ARG19 |
| F | GLY20 |
| F | ILE21 |
| F | GLY22 |
| F | ASN90 |
| F | THR190 |
| F | HOH285 |
Functional Information from PROSITE/UniProt
| site_id | PS00061 |
| Number of Residues | 29 |
| Details | ADH_SHORT Short-chain dehydrogenases/reductases family signature. SvvgtmgnagQanYAAAKAGViGFTkSMA |
| Chain | Residue | Details |
| A | SER142-ALA170 |
