Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

3TXX

Crystal structure of putrescine transcarbamylase from Enterococcus faecalis

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004585	molecular_function	ornithine carbamoyltransferase activity
A	0005737	cellular_component	cytoplasm
A	0006520	biological_process	amino acid metabolic process
A	0006591	biological_process	ornithine metabolic process
A	0006596	biological_process	polyamine biosynthetic process
A	0016597	molecular_function	amino acid binding
A	0016740	molecular_function	transferase activity
A	0016743	molecular_function	carboxyl- or carbamoyltransferase activity
A	0033388	biological_process	putrescine biosynthetic process from arginine
A	0033390	biological_process	putrescine biosynthetic process from arginine via N-carbamoylputrescine
A	0050231	molecular_function	putrescine carbamoyltransferase activity
B	0004585	molecular_function	ornithine carbamoyltransferase activity
B	0005737	cellular_component	cytoplasm
B	0006520	biological_process	amino acid metabolic process
B	0006591	biological_process	ornithine metabolic process
B	0006596	biological_process	polyamine biosynthetic process
B	0016597	molecular_function	amino acid binding
B	0016740	molecular_function	transferase activity
B	0016743	molecular_function	carboxyl- or carbamoyltransferase activity
B	0033388	biological_process	putrescine biosynthetic process from arginine
B	0033390	biological_process	putrescine biosynthetic process from arginine via N-carbamoylputrescine
B	0050231	molecular_function	putrescine carbamoyltransferase activity
C	0004585	molecular_function	ornithine carbamoyltransferase activity
C	0005737	cellular_component	cytoplasm
C	0006520	biological_process	amino acid metabolic process
C	0006591	biological_process	ornithine metabolic process
C	0006596	biological_process	polyamine biosynthetic process
C	0016597	molecular_function	amino acid binding
C	0016740	molecular_function	transferase activity
C	0016743	molecular_function	carboxyl- or carbamoyltransferase activity
C	0033388	biological_process	putrescine biosynthetic process from arginine
C	0033390	biological_process	putrescine biosynthetic process from arginine via N-carbamoylputrescine
C	0050231	molecular_function	putrescine carbamoyltransferase activity
D	0004585	molecular_function	ornithine carbamoyltransferase activity
D	0005737	cellular_component	cytoplasm
D	0006520	biological_process	amino acid metabolic process
D	0006591	biological_process	ornithine metabolic process
D	0006596	biological_process	polyamine biosynthetic process
D	0016597	molecular_function	amino acid binding
D	0016740	molecular_function	transferase activity
D	0016743	molecular_function	carboxyl- or carbamoyltransferase activity
D	0033388	biological_process	putrescine biosynthetic process from arginine
D	0033390	biological_process	putrescine biosynthetic process from arginine via N-carbamoylputrescine
D	0050231	molecular_function	putrescine carbamoyltransferase activity
E	0004585	molecular_function	ornithine carbamoyltransferase activity
E	0005737	cellular_component	cytoplasm
E	0006520	biological_process	amino acid metabolic process
E	0006591	biological_process	ornithine metabolic process
E	0006596	biological_process	polyamine biosynthetic process
E	0016597	molecular_function	amino acid binding
E	0016740	molecular_function	transferase activity
E	0016743	molecular_function	carboxyl- or carbamoyltransferase activity
E	0033388	biological_process	putrescine biosynthetic process from arginine
E	0033390	biological_process	putrescine biosynthetic process from arginine via N-carbamoylputrescine
E	0050231	molecular_function	putrescine carbamoyltransferase activity
F	0004585	molecular_function	ornithine carbamoyltransferase activity
F	0005737	cellular_component	cytoplasm
F	0006520	biological_process	amino acid metabolic process
F	0006591	biological_process	ornithine metabolic process
F	0006596	biological_process	polyamine biosynthetic process
F	0016597	molecular_function	amino acid binding
F	0016740	molecular_function	transferase activity
F	0016743	molecular_function	carboxyl- or carbamoyltransferase activity
F	0033388	biological_process	putrescine biosynthetic process from arginine
F	0033390	biological_process	putrescine biosynthetic process from arginine via N-carbamoylputrescine
F	0050231	molecular_function	putrescine carbamoyltransferase activity
G	0004585	molecular_function	ornithine carbamoyltransferase activity
G	0005737	cellular_component	cytoplasm
G	0006520	biological_process	amino acid metabolic process
G	0006591	biological_process	ornithine metabolic process
G	0006596	biological_process	polyamine biosynthetic process
G	0016597	molecular_function	amino acid binding
G	0016740	molecular_function	transferase activity
G	0016743	molecular_function	carboxyl- or carbamoyltransferase activity
G	0033388	biological_process	putrescine biosynthetic process from arginine
G	0033390	biological_process	putrescine biosynthetic process from arginine via N-carbamoylputrescine
G	0050231	molecular_function	putrescine carbamoyltransferase activity
H	0004585	molecular_function	ornithine carbamoyltransferase activity
H	0005737	cellular_component	cytoplasm
H	0006520	biological_process	amino acid metabolic process
H	0006591	biological_process	ornithine metabolic process
H	0006596	biological_process	polyamine biosynthetic process
H	0016597	molecular_function	amino acid binding
H	0016740	molecular_function	transferase activity
H	0016743	molecular_function	carboxyl- or carbamoyltransferase activity
H	0033388	biological_process	putrescine biosynthetic process from arginine
H	0033390	biological_process	putrescine biosynthetic process from arginine via N-carbamoylputrescine
H	0050231	molecular_function	putrescine carbamoyltransferase activity
I	0004585	molecular_function	ornithine carbamoyltransferase activity
I	0005737	cellular_component	cytoplasm
I	0006520	biological_process	amino acid metabolic process
I	0006591	biological_process	ornithine metabolic process
I	0006596	biological_process	polyamine biosynthetic process
I	0016597	molecular_function	amino acid binding
I	0016740	molecular_function	transferase activity
I	0016743	molecular_function	carboxyl- or carbamoyltransferase activity
I	0033388	biological_process	putrescine biosynthetic process from arginine
I	0033390	biological_process	putrescine biosynthetic process from arginine via N-carbamoylputrescine
I	0050231	molecular_function	putrescine carbamoyltransferase activity
J	0004585	molecular_function	ornithine carbamoyltransferase activity
J	0005737	cellular_component	cytoplasm
J	0006520	biological_process	amino acid metabolic process
J	0006591	biological_process	ornithine metabolic process
J	0006596	biological_process	polyamine biosynthetic process
J	0016597	molecular_function	amino acid binding
J	0016740	molecular_function	transferase activity
J	0016743	molecular_function	carboxyl- or carbamoyltransferase activity
J	0033388	biological_process	putrescine biosynthetic process from arginine
J	0033390	biological_process	putrescine biosynthetic process from arginine via N-carbamoylputrescine
J	0050231	molecular_function	putrescine carbamoyltransferase activity
K	0004585	molecular_function	ornithine carbamoyltransferase activity
K	0005737	cellular_component	cytoplasm
K	0006520	biological_process	amino acid metabolic process
K	0006591	biological_process	ornithine metabolic process
K	0006596	biological_process	polyamine biosynthetic process
K	0016597	molecular_function	amino acid binding
K	0016740	molecular_function	transferase activity
K	0016743	molecular_function	carboxyl- or carbamoyltransferase activity
K	0033388	biological_process	putrescine biosynthetic process from arginine
K	0033390	biological_process	putrescine biosynthetic process from arginine via N-carbamoylputrescine
K	0050231	molecular_function	putrescine carbamoyltransferase activity
L	0004585	molecular_function	ornithine carbamoyltransferase activity
L	0005737	cellular_component	cytoplasm
L	0006520	biological_process	amino acid metabolic process
L	0006591	biological_process	ornithine metabolic process
L	0006596	biological_process	polyamine biosynthetic process
L	0016597	molecular_function	amino acid binding
L	0016740	molecular_function	transferase activity
L	0016743	molecular_function	carboxyl- or carbamoyltransferase activity
L	0033388	biological_process	putrescine biosynthetic process from arginine
L	0033390	biological_process	putrescine biosynthetic process from arginine via N-carbamoylputrescine
L	0050231	molecular_function	putrescine carbamoyltransferase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 G 340

Chain	Residue
G	ARG56
H	ARG56
I	ARG56
I	TYR72

site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 L 340

Chain	Residue
L	TYR72
J	ARG56
J	TYR72
K	ARG56
K	TYR72
L	ARG56

site_id	AC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 B 340

Chain	Residue
A	ARG56
A	TYR72
B	ARG56
B	TYR72
C	ARG56

site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 E 340

Chain	Residue
D	ARG56
E	ARG56
E	TYR72
F	ARG56

site_id	AC5
Number of Residues	8
Details	BINDING SITE FOR RESIDUE SO4 B 341

Chain	Residue
B	SER52
B	ARG54
B	THR55
B	ARG103
B	HIS130
B	ARG297
B	SO4342
E	HIS-12

site_id	AC6
Number of Residues	9
Details	BINDING SITE FOR RESIDUE SO4 E 341

Chain	Residue
E	SER52
E	ARG54
E	THR55
E	ARG103
E	HIS130
E	CYS269
E	LEU270
E	ARG297
E	SO4342

site_id	AC7
Number of Residues	7
Details	BINDING SITE FOR RESIDUE SO4 D 340

Chain	Residue
D	SER52
D	ARG54
D	THR55
D	ARG103
D	HIS130
D	LEU270
D	ARG297

site_id	AC8
Number of Residues	8
Details	BINDING SITE FOR RESIDUE SO4 H 340

Chain	Residue
H	SER52
H	ARG54
H	THR55
H	ARG103
H	HIS130
H	GLN133
H	ARG297
H	SO4341

site_id	AC9
Number of Residues	7
Details	BINDING SITE FOR RESIDUE SO4 C 340

Chain	Residue
C	SER52
C	ARG54
C	THR55
C	ARG103
C	HIS130
C	ARG297
C	SO4341

site_id	BC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 E 342

Chain	Residue
E	SER52
E	THR53
E	ARG54
E	SO4341

site_id	BC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 B 342

Chain	Residue
A	GLN79
B	THR53
B	ARG54
B	SO4341

site_id	BC3
Number of Residues	8
Details	BINDING SITE FOR RESIDUE SO4 J 340

Chain	Residue
J	SER52
J	ARG54
J	THR55
J	ARG103
J	HIS130
J	LEU270
J	ARG297
J	SO4341

site_id	BC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 H 341

Chain	Residue
H	SER52
H	THR53
H	ARG54
H	SO4340

site_id	BC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 A 340

Chain	Residue
A	SER52
A	THR53
A	ARG54

site_id	BC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 F 340

Chain	Residue
F	SER52
F	THR53
F	ARG54
F	SO4341

site_id	BC7
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 D 341

Chain	Residue
D	ARG91
D	ARG95

site_id	BC8
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 A 341

Chain	Residue
A	ARG91
A	ARG95

site_id	BC9
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 G 341

Chain	Residue
G	SER51
G	SER52
G	THR53
G	ARG54
G	SO4342

site_id	CC1
Number of Residues	9
Details	BINDING SITE FOR RESIDUE SO4 G 342

Chain	Residue
G	CYS269
G	LEU270
G	ARG297
G	SO4341
G	SER52
G	ARG54
G	THR55
G	ARG103
G	HIS130

site_id	CC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 L 341

Chain	Residue
L	ARG54
L	THR55
L	ARG103
L	HIS130
L	ARG297
L	SO4342

site_id	CC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 I 340

Chain	Residue
I	SER52
I	THR53
I	ARG54
I	SO4341

site_id	CC4
Number of Residues	7
Details	BINDING SITE FOR RESIDUE SO4 F 341

Chain	Residue
F	SER52
F	ARG54
F	THR55
F	ARG103
F	HIS130
F	ARG297
F	SO4340

site_id	CC5
Number of Residues	7
Details	BINDING SITE FOR RESIDUE SO4 I 341

Chain	Residue
I	SER52
I	ARG54
I	THR55
I	ARG103
I	HIS130
I	ARG297
I	SO4340

site_id	CC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 C 341

Chain	Residue
C	SER52
C	THR53
C	ARG54
C	SO4340

site_id	CC7
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 K 340

Chain	Residue
K	SER52
K	ARG54
K	ARG103

site_id	CC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 L 342

Chain	Residue
L	SER52
L	THR53
L	ARG54
L	SO4341

site_id	CC9
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 J 341

Chain	Residue
J	SER52
J	THR53
J	ARG54
J	SO4340

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	48
Details	BINDING: BINDING => ECO:0000250

Chain	Residue	Details
A	SER52
C	ARG103
C	HIS130
C	HIS268
D	SER52
D	ARG103
D	HIS130
D	HIS268
E	SER52
E	ARG103
E	HIS130
A	ARG103
E	HIS268
F	SER52
F	ARG103
F	HIS130
F	HIS268
G	SER52
G	ARG103
G	HIS130
G	HIS268
H	SER52
A	HIS130
H	ARG103
H	HIS130
H	HIS268
I	SER52
I	ARG103
I	HIS130
I	HIS268
J	SER52
J	ARG103
J	HIS130
A	HIS268
J	HIS268
K	SER52
K	ARG103
K	HIS130
K	HIS268
L	SER52
L	ARG103
L	HIS130
L	HIS268
B	SER52
B	ARG103
B	HIS130
B	HIS268
C	SER52

site_id	SWS_FT_FI2
Number of Residues	24
Details	SITE: Important for structural integrity => ECO:0000250

Chain	Residue	Details
A	LYS27
E	GLU143
F	LYS27
F	GLU143
G	LYS27
G	GLU143
H	LYS27
H	GLU143
I	LYS27
I	GLU143
J	LYS27
A	GLU143
J	GLU143
K	LYS27
K	GLU143
L	LYS27
L	GLU143
B	LYS27
B	GLU143
C	LYS27
C	GLU143
D	LYS27
D	GLU143
E	LYS27

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)