3TWY

RAT PKC C2 DOMAIN BOUND TO PB

Replaces:  3RDL

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004674	molecular_function	protein serine/threonine kinase activity
A	0005524	molecular_function	ATP binding
A	0006468	biological_process	protein phosphorylation

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE PB A 1

Chain	Residue
A	HOH85
A	ASP187
A	ASP193
A	ASP246
A	TRP247
A	ASP248

---

site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE PB A 2

Chain	Residue
A	ASP246
A	ASP248
A	ASP254
A	HOH76
A	MET186
A	ASP187

---

site_id	AC3
Number of Residues	8
Details	BINDING SITE FOR RESIDUE SO4 A 293

Chain	Residue
A	SO43
A	HOH119
A	LYS181
A	LYS197
A	LYS199
A	ASN206
A	LYS209
A	GLN222

---

site_id	AC4
Number of Residues	10
Details	BINDING SITE FOR RESIDUE SO4 A 294

Chain	Residue
A	HOH42
A	HOH53
A	HOH65
A	HOH95
A	HOH124
A	LYS172
A	LYS230
A	ARG252
A	ASN253
A	HOH316

---

site_id	AC5
Number of Residues	10
Details	BINDING SITE FOR RESIDUE SO4 A 3

Chain	Residue
A	HOH31
A	HOH95
A	TYR195
A	LYS197
A	LYS209
A	LYS211
A	ASN253
A	SO4293
A	HOH320
A	HOH348

---

site_id	AC6
Number of Residues	7
Details	BINDING SITE FOR RESIDUE SO4 A 4

Chain	Residue
A	HOH22
A	HOH48
A	ARG239
A	PHE261
A	GLY262
A	GLU265
A	ASN287

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	117
Details	Domain: {"description":"C2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00041","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"10562545","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	7
Details	Binding site: {"evidences":[{"source":"PubMed","id":"10562545","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19346474","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"19346474","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"22673903","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---