Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

3TW6

Structure of Rhizobium etli pyruvate carboxylase T882A with the allosteric activator, acetyl coenzyme-A

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003824	molecular_function	catalytic activity
A	0004736	molecular_function	pyruvate carboxylase activity
A	0005524	molecular_function	ATP binding
A	0005737	cellular_component	cytoplasm
A	0006090	biological_process	pyruvate metabolic process
A	0006094	biological_process	gluconeogenesis
A	0016874	molecular_function	ligase activity
A	0046872	molecular_function	metal ion binding
B	0003824	molecular_function	catalytic activity
B	0004736	molecular_function	pyruvate carboxylase activity
B	0005524	molecular_function	ATP binding
B	0005737	cellular_component	cytoplasm
B	0006090	biological_process	pyruvate metabolic process
B	0006094	biological_process	gluconeogenesis
B	0016874	molecular_function	ligase activity
B	0046872	molecular_function	metal ion binding
C	0003824	molecular_function	catalytic activity
C	0004736	molecular_function	pyruvate carboxylase activity
C	0005524	molecular_function	ATP binding
C	0005737	cellular_component	cytoplasm
C	0006090	biological_process	pyruvate metabolic process
C	0006094	biological_process	gluconeogenesis
C	0016874	molecular_function	ligase activity
C	0046872	molecular_function	metal ion binding
D	0003824	molecular_function	catalytic activity
D	0004736	molecular_function	pyruvate carboxylase activity
D	0005524	molecular_function	ATP binding
D	0005737	cellular_component	cytoplasm
D	0006090	biological_process	pyruvate metabolic process
D	0006094	biological_process	gluconeogenesis
D	0016874	molecular_function	ligase activity
D	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CL A 1600

Chain	Residue
A	GLY63
A	PRO64
A	ILE65
A	GLU66

site_id	AC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL A 1601

Chain	Residue
A	TYR987
A	LYS989
A	VAL990

site_id	AC3
Number of Residues	9
Details	BINDING SITE FOR RESIDUE ADP A 2000

Chain	Residue
A	VAL211
A	HIS216
A	GLN240
A	ASN243
A	LEU285
A	GLU297
A	MG2002
A	LYS209
A	LEU210

site_id	AC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ZN A 2001

Chain	Residue
A	ASP549
A	KCX718
A	HIS747
A	HIS749
A	HOH1251

site_id	AC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE MG A 2002

Chain	Residue
A	GLU283
A	GLU297
A	ADP2000

site_id	AC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG A 2005

Chain	Residue
A	MET534
A	ARG535
A	GLU537
A	ASP768
A	HOH1182
A	HOH1245

site_id	AC7
Number of Residues	11
Details	BINDING SITE FOR RESIDUE COA A 4011

Chain	Residue
A	ARG429
A	ARG469
A	GLN470
A	ASP471
A	ARG472
A	THR1031
A	LEU1032
A	ASN1055
B	ARG43
B	PHE44
B	HOH1343

site_id	AC8
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL B 1600

Chain	Residue
B	GLY63
B	ILE65
B	GLU66

site_id	AC9
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL B 1601

Chain	Residue
B	TYR987
B	LYS989
B	VAL990

site_id	BC1
Number of Residues	20
Details	BINDING SITE FOR RESIDUE ADP B 2000

Chain	Residue
B	LYS124
B	LYS166
B	GLY171
B	GLY173
B	ARG174
B	MET176
B	GLU208
B	LYS209
B	LEU210
B	VAL211
B	HIS216
B	GLN240
B	ASN243
B	GLU283
B	LEU285
B	GLU297
B	THR454
B	HOH1222
B	HOH1223
B	MG2002

site_id	BC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ZN B 2001

Chain	Residue
B	ASP549
B	KCX718
B	HIS747
B	HIS749
B	HOH1376

site_id	BC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MG B 2002

Chain	Residue
B	GLU283
B	GLU297
B	HOH1228
B	ADP2000

site_id	BC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE BTI B 2003

Chain	Residue
B	ARG353
B	THR355
B	ASP399
B	ASN434
B	LYS1119
B	HOH1235

site_id	BC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG B 2005

Chain	Residue
B	MET534
B	ARG535
B	GLU537
B	ASP768
B	HOH1348
B	HOH1349

site_id	BC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CL C 1600

Chain	Residue
C	GLY63
C	PRO64
C	ILE65
C	GLU66

site_id	BC7
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL C 1601

Chain	Residue
C	TYR987
C	LYS989
C	VAL990

site_id	BC8
Number of Residues	14
Details	BINDING SITE FOR RESIDUE ADP C 2000

Chain	Residue
C	LEU210
C	VAL211
C	HIS216
C	GLN240
C	GLU283
C	GLU297
C	THR454
C	HOH1302
C	MG2002
C	PAE2003
C	LYS166
C	MET176
C	GLU208
C	LYS209

site_id	BC9
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ZN C 2001

Chain	Residue
C	ASP549
C	KCX718
C	HIS747
C	HIS749
C	HOH1160

site_id	CC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG C 2002

Chain	Residue
C	GLU283
C	GLU297
C	HOH1302
C	ADP2000
C	PAE2003

site_id	CC2
Number of Residues	12
Details	BINDING SITE FOR RESIDUE PAE C 2003

Chain	Residue
C	LYS245
C	GLU283
C	GLU297
C	ASN299
C	ARG301
C	GLN303
C	VAL304
C	GLU305
C	HOH1302
C	HOH1304
C	ADP2000
C	MG2002

site_id	CC3
Number of Residues	14
Details	BINDING SITE FOR RESIDUE COA C 4011

Chain	Residue
C	ARG427
C	ARG429
C	LYS468
C	ARG469
C	GLN470
C	ASP471
C	ARG472
C	ALA473
C	ILE1026
C	THR1031
C	LEU1032
D	PHE44
D	HOH1263
D	HOH1329

site_id	CC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CL D 1600

Chain	Residue
D	GLY63
D	PRO64
D	ILE65
D	GLU66

site_id	CC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL D 1601

Chain	Residue
D	TYR987
D	LYS989
D	VAL990

site_id	CC6
Number of Residues	13
Details	BINDING SITE FOR RESIDUE ADP D 2000

Chain	Residue
D	LYS166
D	MET176
D	LYS209
D	LEU210
D	VAL211
D	HIS216
D	GLN240
D	ASN243
D	GLU283
D	LEU285
D	GLU297
D	THR454
D	MG2002

site_id	CC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ZN D 2001

Chain	Residue
D	ASP549
D	KCX718
D	HIS747
D	HIS749
D	HOH1340

site_id	CC8
Number of Residues	3
Details	BINDING SITE FOR RESIDUE MG D 2002

Chain	Residue
D	GLU283
D	GLU297
D	ADP2000

site_id	CC9
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG D 2005

Chain	Residue
D	MET534
D	ARG535
D	GLU537
D	ASP768
D	HOH1156
D	HOH1353

Functional Information from PROSITE/UniProt

site_id	PS00188
Number of Residues	18
Details	BIOTIN Biotin-requiring enzymes attachment site. GDvLvsIeAMKMetaIhA

Chain	Residue	Details
A	GLY1109-ALA1126

site_id	PS00866
Number of Residues	15
Details	CPSASE_1 Carbamoyl-phosphate synthase subdomain signature 1. YPVMLKASwggGGrG

Chain	Residue	Details
A	TYR161-GLY175

site_id	PS00867
Number of Residues	8
Details	CPSASE_2 Carbamoyl-phosphate synthase subdomain signature 2. FIEVNPRI

Chain	Residue	Details
A	PHE295-ILE302

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)