Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0004146 | molecular_function | dihydrofolate reductase activity |
| A | 0005829 | cellular_component | cytosol |
| A | 0006730 | biological_process | one-carbon metabolic process |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0046452 | biological_process | dihydrofolate metabolic process |
| A | 0046654 | biological_process | tetrahydrofolate biosynthetic process |
| A | 0046655 | biological_process | folic acid metabolic process |
| A | 0050661 | molecular_function | NADP binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 33 |
| Details | BINDING SITE FOR RESIDUE NDP A 1001 |
| Chain | Residue |
| A | ALA7 |
| A | ARG46 |
| A | THR47 |
| A | ILE63 |
| A | THR64 |
| A | GLN65 |
| A | GLN66 |
| A | TYR78 |
| A | SER79 |
| A | ILE96 |
| A | GLY97 |
| A | ALA8 |
| A | GLY98 |
| A | ALA99 |
| A | ARG100 |
| A | ILE101 |
| A | GLU104 |
| A | HOH191 |
| A | HOH237 |
| A | HOH284 |
| A | HOH292 |
| A | HOH302 |
| A | ILE15 |
| A | HOH306 |
| A | HOH336 |
| A | HOH374 |
| A | TOP2001 |
| A | GLY16 |
| A | ASN19 |
| A | GLU20 |
| A | LEU21 |
| A | GLY44 |
| A | ARG45 |
| site_id | AC2 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE TOP A 2001 |
| Chain | Residue |
| A | ILE6 |
| A | ALA7 |
| A | ALA8 |
| A | LEU21 |
| A | ASP28 |
| A | PHE32 |
| A | SER50 |
| A | ILE96 |
| A | HOH230 |
| A | HOH231 |
| A | HOH240 |
| A | NDP1001 |
Functional Information from PROSITE/UniProt
| site_id | PS00075 |
| Number of Residues | 23 |
| Details | DHFR_1 Dihydrofolate reductase (DHFR) domain signature. LIGrnneLPWhlpa.DlahFksiT |
| Chain | Residue | Details |
| A | LEU14-THR36 | |
