3TPO
Crystal structure of D192A/E396A mutant of mouse importin alpha2
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005515 | molecular_function | protein binding |
| A | 0005634 | cellular_component | nucleus |
| A | 0005654 | cellular_component | nucleoplasm |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0006606 | biological_process | protein import into nucleus |
| A | 0006607 | biological_process | NLS-bearing protein import into nucleus |
| A | 0008139 | molecular_function | nuclear localization sequence binding |
| A | 0010494 | cellular_component | cytoplasmic stress granule |
| A | 0014069 | cellular_component | postsynaptic density |
| A | 0015031 | biological_process | protein transport |
| A | 0031965 | cellular_component | nuclear membrane |
| A | 0032481 | biological_process | positive regulation of type I interferon production |
| A | 0038061 | biological_process | non-canonical NF-kappaB signal transduction |
| A | 0042564 | cellular_component | NLS-dependent protein nuclear import complex |
| A | 0042826 | molecular_function | histone deacetylase binding |
| A | 0043657 | cellular_component | host cell |
| A | 0045893 | biological_process | positive regulation of DNA-templated transcription |
| A | 0046015 | biological_process | regulation of transcription by glucose |
| A | 0061608 | molecular_function | nuclear import signal receptor activity |
| A | 0075506 | biological_process | entry of viral genome into host nucleus through nuclear pore complex via importin |
| A | 0098978 | cellular_component | glutamatergic synapse |
| A | 0099527 | biological_process | postsynapse to nucleus signaling pathway |
| A | 0140297 | molecular_function | DNA-binding transcription factor binding |
| A | 1903902 | biological_process | positive regulation of viral life cycle |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 40 |
| Details | Repeat: {"description":"ARM 1; truncated"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 39 |
| Details | Repeat: {"description":"ARM 2"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 41 |
| Details | Repeat: {"description":"ARM 3"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 44 |
| Details | Repeat: {"description":"ARM 4"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 36 |
| Details | Repeat: {"description":"ARM 5"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 39 |
| Details | Repeat: {"description":"ARM 6"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 39 |
| Details | Repeat: {"description":"ARM 7"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 42 |
| Details | Repeat: {"description":"ARM 8"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 46 |
| Details | Repeat: {"description":"ARM 9"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 39 |
| Details | Repeat: {"description":"ARM 10; atypical"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 96 |
| Details | Region: {"description":"NLS binding site (major)","evidences":[{"source":"PubMed","id":"10764582","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI12 |
| Number of Residues | 88 |
| Details | Region: {"description":"NLS binding site (minor)","evidences":[{"source":"PubMed","id":"10764582","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI13 |
| Number of Residues | 9 |
| Details | Motif: {"description":"Nuclear localization signal","evidences":[{"source":"PubMed","id":"10201409","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"10764582","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
